Effectiveness of palivizumab to prevent hospitalization for respiratory syncytial virus infection in preterm infants 321 to 35° weeks' gestation in Spain [Efectividad de palivizumab en la prevención de la infección por el virus respiratorio sincitial en prematuros de 321 a 35° semanas de gestación en España]
Figueras-Aloy J.,Servicio de Neonatologia |
Carbonell-Estrany X.,Servicio de Neonatologia |
Quero-Jimenez J.,Hospital Universitario La Paz |
Fernandez-Colomer B.,Hospital Central de Asturias |
And 42 more authors.
Acta Pediatrica Espanola | Year: 2010
Objective: The objective of the study was to evaluate effectiveness of palivizumab to prevent respiratory syncytial virus (RSV) infection when administered to former preterm infants 321 to 35° weeks' gestation aged less than 6 months at the beginning of RSV season using any of the possible combinations of known risk factors for RSV hospitalization. Patients and methods: Data were retrieved from the FLIP-2 study database. Infants without risk factors were excluded. The database included 627 infants who received palivizumab and 4,092 who did not. Seven accumulative subgroups were established according to the combinations of risk factors combining two "major factors" (chronological age less than 10 weeks at the beginning of RSV season or being born during the first 10 weeks of the season; school-age siblings or daycare attendance) and two "minor factors" (mother smoking during pregnancy; male gender). Absolute risk, relative risk, and number needed to treat (NNT) were obtained for each subgroup. Results: In each subgroup, birth weight and gestational age were significantly lower in palivizumab treated infants. The combination "2 major factors" showed a NNT of [13.5], and when merged with "1 major factor or 2 minor factors" the NNT reached 15.1. Combination requesting only one risk factor either major or minor corresponded by design to the global study. 186 patients of the treated group (4.55%) and 9 patients of the non-treated group (1.44%) were admitted to the hospital, of the treated (p <0.001; NNT of 32.2). Conclusion: In former preterm infants 321 to 35° weeks' gestation with chronological age less than 10 weeks at the beginning of RSV season (or being born during the first 10 weeks of the season) and with school-age siblings or daycare attendance, 14 should be treated with palivizumab to prevent one RSV hospitalization.
Ocete-Hita E.,Complejo Hospitalario Universitario Of Granada |
Ocete-Hita E.,University of Granada |
Ocete-Hita E.,CIBER ISCIII |
Sameron-Fernandez M.J.,Complejo Hospitalario Universitario Of Granada |
And 9 more authors.
Nutricion Hospitalaria | Year: 2015
The consumption of herbal products is mainly due to the perception that being “natural” can only be beneficial and without risk to health. However the properties thereof are poorly studied and proven. Four episodes are presented of hepatotoxicity from the consumption of herbal products, by three children. We analyse the epidemiological and clinical characteristics of these products, and stress the importance of proper anamnesis for accurate diagnosis. © 2015, Grupo Aula Medica S.A. All rights reserved.
Haro-Mora J.J.,Laboratorio Of Investigacion |
Haro-Mora J.J.,Institute Salud Carlos III |
Garcia-Escobar E.,Laboratorio Of Investigacion |
Garcia-Escobar E.,Institute Salud Carlos III |
And 16 more authors.
European Journal of Endocrinology | Year: 2011
Objective: Changes in eating habits may be influential in the ever-increasing rate of childhood obesity. Our aim was to determine whether those children who consume olive oil have a lower risk of weight gain compared with children who consume other oils. Design and methods: The study included 18 girls and 74 boys, all aged 13-166 months. A survey was completed for each subject about eating habits and physical activity. A sample of subcutaneous adipose tissue was also obtained for cellular study. Data were recorded on the mean size of the adipocytes, the number of preadipocytes, and the concentration of particular fatty acids. The weight and height of the children were measured 13 months later. Results: The likelihood that after 1 year the children would have increased their body mass index (BMI) Z-score above the initial score was less in the children who consumed only olive oil (odds ratio (OR)= 0.22; 95% confidence interval (CI): 0.08-0.63; P=0.005). These results remained after adjusting for age, physical activity and BMI (OR=0.19; 95% CI: 0.06-0.61; P=0.005) and after adjusting for age, physical activity and adipocyte volume (OR=0.15; 95% CI: 0.04-0.52; P=0.003). Conclusions: Diets with mono unsaturated fatty acid (MUFA)-rich olive oil could reduce the risk of obesity in childhood. © 2011 European Society of Endocrinology.
Self-reported cases of influenza among Spanish healthcare workers during the 2009 influenza A(H1N1) pandemic [Casos autodeclarados de síndrome gripal en trabajadores sanitarios españoles durante la pandemia de gripe A (H1N1) 2009]
Olalla J.,CIBER ISCIII |
de Ory F.,CIBER ISCIII |
de Ory F.,Institute Salud Carlos III |
Casas I.,CIBER ISCIII |
And 67 more authors.
Gaceta Sanitaria | Year: 2013
Objectives: To describe the prevalence of influenza-like syndrome in winter 2009 and the factors associated with its occurrence. Methods: A cross-sectional study was carried out in 18 hospitals in Spain. Volunteers completed a health questionnaire in which they reported the occurrence of influenza-like syndrome and vaccination and demographic status. Results: A total of 1,289 healthcare workers participated. Of these, 72 (5.6%) reported influenza in their family, 195 (15.1%) had been vaccinated against the A/California/7/2009/H1N1 virus and 75 (5.8%, 95%CI: 4.5-7.1%) had been diagnosed with influenza like-syndrome. There were differences among regions. In logistic regression analysis, the following factors were associated with a higher prevalence of influenza-like syndrome: working in Madrid (OR=8.31, 95%CI: 1.05-65.39), the occurrence of cases of influenza in the family (OR=2.84, 95%CI: 1.41-5.73) and not having been vaccinated against influenza A (H1N1) (OR=2.68, 95% CI: 1.05-6.82). Conclusions: Differences in the prevalence of influenza-like syndrome were due to the occurrence of familiar cases and region. Vaccination against influenza A (H1N1) was associated with a lower prevalence of the disease. © 2011 SESPAS.