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Xàtiva, Spain

Morata Alba J.,Servicio de Pediatria | Jimenez Candel M.I.,Hospital Lluis Alcanyis
Pediatria de Atencion Primaria | Year: 2015

Hyperkalemic periodic paralysis is a channelopathy of the skeletal muscle that is characterized by recurrent episodes of muscle weakness that may be triggered by exercise, cold, rest or shortly after exercise and potassium intake. We describe the case of a four-year-old girl with a family history of hyperkalemic periodic paralysis and an episode of weakness in legs. She was asymptomatic until about six months before. Concern about three episodes of muscle weakness and numbness of legs at night, which resolve spontaneously in a few minutes. No other associated symptoms. © 2015, Spanish Association of Primary Care Pediatrics. All rights reserved. Source

Villanueva V.,Polytechnic University of Valencia | Serratosa J.M.,Hospital Universitario Fundacion Jimenez Diaz | Guillamon E.,Polytechnic University of Valencia | Garces M.,Polytechnic University of Valencia | And 14 more authors.
Epilepsy Research | Year: 2014

Background: Eslicarbazepine acetate (ESL) is a new antiepileptic drug (AED) licensed as adjunctive therapy in adults with partial-onset or focal seizures. Objective: To evaluate in a clinical practice setting the long-term efficacy and safety of ESL in patients with focal seizures. Methods: ESLIBASE was a retrospective study that included all patients with focal seizures who started ESL between January 2010 and July 2012 at 12 hospitals. ESL was prescribed individually according to real-life practice. Efficacy and safety were evaluated over 1 year. Switching from carbamazepine (CBZ) and oxcarbazepine (OXC) was assessed. Results: Three hundred and twenty-seven patients were included; 78% of patients were taking ≥2 other AEDs at baseline. Most (87%) began ESL because of poor seizure control and13% because of adverse events (AEs) with CBZ or OXC. After 1 year, 237 patients (72.4%) remained on ESL. At 3, 6 and 12 months, the responder rate was 46.3%, 57.9%, and 52.5%, and 21.0%, 28.0%, and 25.3% of patients were seizure free. The responder rate significantly increased when ESL was combined with a non-sodium channel-targeting drug (non-SC drug) (66.7%) versus an SC drug (47.7%; p< 0.001). At 12 months, 40.7% of patients had ≥1 AE; AEs led to treatment discontinuation in 16.2%. Dizziness, nausea, and somnolence were the most common AEs. The tolerability profile improved in >50% of the patients who switched from CBZ or OXC to ESL because of AEs. Conclusions: ESL was well tolerated and effective in a real-world setting over 1 year. Side-effect profile improved when OXC and CBZ recipients were switched to ESL. © 2014 Elsevier B.V. Source

Banaclocha M.A.M.,Hospital Lluis Alcanyis | Banaclocha H.M.,Hospital Universitario Virgen Of La Arrixaca
NeuroQuantology | Year: 2010

The results of various recent and independent investigations show, unequivocally, that cerebral neocortex is continuously and spontaneously working, even without any afferent input. These findings suggest that neuronal microcircuits in the neocortex have autonomic activity and support the concept that some cognitive functions may be the result of the functional self-organisation among their cellular components. From a theoretical perspective, it is proposed that spontaneous neocortical activity can be explained not only by electrophysiological and synaptic mechanisms but also as the result of the close magnetic interactions between astrocytes and neighboring neurons. This neuron-astroglial bio-magnetic interplay may underlie spontaneous neocortical activity and consequently some spontaneous cognitive functions. Source

Roig J.V.,Consorcio Hospital General Universitario | Cantos M.,Consorcio Hospital General Universitario | Balciscueta Z.,Hospital Universitario Arnau Of Vilanova | Uribe N.,Hospital Universitario Arnau Of Vilanova | And 5 more authors.
Colorectal Disease | Year: 2011

Aim The study evaluated the rate of reversal of Hartmann's operation after the initial surgery and its morbidity. Method A multicentre retrospective study was carried out in seven hospitals in the Valencia area of patients who underwent Hartmann's operation from 2004 to 2008. The incidence of reversal was determined. Results Four hundred and fifty-two patients of mean age 67.5±15.4years were included, of whom 78.8% had an emergency operation. The most common diagnosis was cancer (58.6%), although diverticulitis predominated in the emergency setting. At a median follow up of 44months, 159 (35.2%) patients had undergone reversal, including 16.6% after elective surgery and 40.4% after an emergency Hartmann's procedure (P<0.001). The most frequent reason why reversal was not done was death (74 [25%] patients). Patients undergoing reversal were younger and had a low ASA risk. Trauma was associated with a higher rate of reversal, followed by diverticular disease. Surgery was performed at a median of 10months. An open approach with stapled anastomosis was used in most cases. The mortality was 3.5%. Complications occurred in 45.2%, with a 6.2% rate of anastomotic leakage. Complications were associated with age, diabetes mellitus, arteriosclerosis, obesity, smoking, chemotherapy and COPD. Conclusion Hartmann's reversal was performed in a small percentage of patients, mostly including those with benign disease. It had a significant morbidity. © 2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland. Source

Vegue L.B.,Hospital Lluis Alcanyis | Munoz R.C.,Hospital de la Ribera | Madrona A.P.,University of Murcia
Expert Review of Molecular Diagnostics | Year: 2012

Axillary lymph node status at the time of diagnosis is the most important prognostic indicator for women with breast cancer, and may influence management decisions. However, at present its role is controversial, as some groups recommend avoiding axillary lymph node dissection (ALND) in cases with metastasis of any size in the sentinel lymph nodes. Molecular analysis allows full examination of the sentinel lymph nodes in a short time period, discriminatation between macrometastasis, micrometastasis and isolated tumor cells, and helps to predict the performance of ALND. ALND may be the treatment of choice in some patients, even in cases of low-volume metastasis, as chemotherapy does not control regional disease well. In addition, the collection of metastatic cells, as well as the local immune surveillance, is susceptible to further molecular studies that will offer prognostic and predictive information, which may have an impact on therapeutic decisions, so that individualized treatments can be adequately designed. © 2012 Expert Reviews Ltd. Source

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