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Gomez S.,Instituto Nacional Of Enfermedades Infecciosas Inei | Rapoport M.,Hospital Interzonal General de Agudos Evita | Togneri A.,Instituto Nacional Of Enfermedades Infecciosas Inei | Viegas-Caetano J.,Hospital Interzonal General de Agudos San Martin | And 4 more authors.
Diagnostic Microbiology and Infectious Disease | Year: 2011

Carbapenem susceptibility in Enterobacteriaceae (M9921, M9959) revealed the presence of MBLs blaVIM-2 (M9959) and blaIMP-8 (M9921), both as first cassettes of class-1-integrons. ESBL blaPER-2 was detected in both strains and M9921 also harboured qnrB10, aac(6β)-Ib and aac(6')-Ib-cr. This is the first report of MBLs in Enterobacteriaceae from Argentina. © 2011 Elsevier Inc. Source

Ferolla F.M.,Fundacion INFANT | Ferolla F.M.,CONICET | Hijano D.R.,Fundacion INFANT | Hijano D.R.,North South University | And 37 more authors.
American Journal of Respiratory and Critical Care Medicine | Year: 2013

Rationale: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. Objectives: We defined the burden of life-threatening (O 2 saturation [O2 sat] ≤ 87%) and fatal RSV infection, and characterized risk factors for life-threatening disease in hospitalized children. Special emphasis was placed on studying the impact of dietary habits during pregnancy. We hypothesized that dietary preferences, differing from those of our remote ancestors, would negatively impact children's pulmonary health. For instance, a diet rich in carbohydrates is a signature of recent millennia and typical of low-income populations, heavily burdened by life-threatening RSV disease. Methods: Prospective study inacatchment population of 56, 560 children under 2 years of age during the RSV season in Argentina. All children with respiratory signs and O2sat less than 93% on admission were included. Measurements and Main Results: Among 1, 293 children with respiratory infections, 797(61.6%) were infected with RSV: 106 of thesehad life-threatening disease; 1.9 per 1, 000 children (95% confidence interval [CI], 1.5-2.2/1, 000) under 24 months. A total of 22 hospitalized children died(9 RSV+), 26 died at home due to acute respiratory infection (14 attributed to RSV); all were under 12 months old. The annual attributable mortality rate for RSV was 0.7 per 1, 000 infants (95% CI, 0.4-1.1/1, 000). Life-threatening disease was dose-dependently associated with carbohydrate ingestion during pregnancy (adjusted odds ratio from 3.29 [95% CI, 1.15-9.44] to 7.36 [95% CI, 2.41-22.5] versus the lowest quartile). Conclusions: Life-threatening and fatal RSV infections are a heavy burden on infants in the developing world. Diets rich in carbohydrates during pregnancy are associated withthese severe outcomes. Copyright © 2013 by the American Thoracic Society. Source

Rosenthal V.D.,International Nosocomial Infection Control Consortium INICC | Rosenthal V.D.,Centro Medico Bernal | Rosenthal V.D.,Centro Medico Colegiales | Viegas M.,Hospital Interzonal General de Agudos Presidente Peron | And 17 more authors.
Journal of Nursing Care Quality | Year: 2015

We evaluated the impact of the International Nosocomial Infection Control Consortium multidimensional approach to hand hygiene in 11 intensive care units in 4 cities in Argentina and analyzed predictors of poor hand hygiene compliance. We had a baseline period and a follow-up period. We observed 21 100 hand hygiene opportunities. Hand hygiene compliance increased from 28.3% to 64.8% (P =.0001). Males versus females (56.8% vs 66.4%; P <.001) and physicians versus nurses (46.6% vs 67.8%; P <.001) were significantly associated with poor hand hygiene compliance. © 2015 Wolters Kluwer Health, Inc. All rights reserved. Source

Faccone D.,Instituto Nacional Of Enfermedades Infecciosas Anlis Dr Carlos G Malbran | Togneri A.M.,Hospital Interzonal General de Agudos Evita | Podesta L.,Hospital Interzonal General de Agudos Evita | Perez M.,Hospital Interzonal General de Agudos Evita | And 4 more authors.
Infection, Genetics and Evolution | Year: 2014

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of both nosocomial and community-acquired infections. We describe an outbreak caused by the MRSA Pediatric clone expressing an unusual lincosamide resistant phenotype. Between January and May 2006, an MRSA outbreak was detected at the Neonatal Unit of Hospital Interzonal General de Agudos "Evita", Buenos Aires Province, Argentina that affected ten patients. Seven isolates from seven patients plus five MRSA recovered from health care workers (nasal carriage) were studied. Two phenotypes were observed: (i) ELCi (10), resistance to erythromycin and lincomycin and inducible resistance to clindamycin; (ii) ELiCi (2), resistance to erythromycin and inducible resistance to lincomycin and clindamycin. All 12 MRSA were resistant to oxacillin, erythromycin and gentamicin. Isolates expressing the ELCi-phenotype showed lincomycin MIC values between 16 and 32. mg/L, while the remaining 2 isolates with ELiCi-phenotype presented a MIC value of 0.5. mg/L. No differences were observed between the clindamycin MIC values in both phenotypes, ranging 0.25-0.5. mg/L. Isolates showing ELCi-phenotype harbored ermC plus lnuA genes, and the other two only ermC gene. All 12 isolates were genetically related and belonged to the Pediatric clone (ST100) harboring a new variant of SCC. mecIV. This is the first MRSA outbreak expressing an unusual ELCi phenotype due to a combination of ermC plus lnuA genes. © 2014 Elsevier B.V. Source

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