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Aveiro, Portugal

Oliveira I.C.,Institute of Electronics and Informatics Engineering of Aveiro | Oliveira I.C.,University of Aveiro | Silva N.,Hospital Infante Dom Pedro | Da Veiga I.,Institute of Electronics and Informatics Engineering of Aveiro | And 2 more authors.
HEALTHINF 2012 - Proceedings of the International Conference on Health Informatics | Year: 2012

Technological advances in mobile phones make them appealing to support nursing care at the point of treatment, especially by combining the easy-of-use, mobility and wireless communications. Novel capabilities, such as picture capturing, enlarge the applications scope. In this work, we present the HOPE system to facilitate nursing care documentation, by leveraging on standard off-the-shelf mobile phones. The proposed system moves a substantial part of the work usually deferred and performed at desktop computers to the moment and place of care. In addition, health professionals can document the clinical cases with photos, using the mobile phone built-in camera, which is being applied in diabetic foot consultation. Basic support for wound measurement is available. The information acquired is integrated in the patient's Electronic Health Record and can be shared using the mobile devices or the workstations. The proposed system is in pilot use at two Portuguese hospitals targeting inpatient care and diabetic foot consulting.

Domingues D.,Portuguese Oncology Institute IPO PORTO | Turner A.,University of Otago | Silva M.D.,Hospital Infante Dom Pedro | Marques D.S.,Portuguese Oncology Institute IPO PORTO | And 5 more authors.
Immunotherapy | Year: 2014

Non-small-cell lung cancer (NSCLC) is a highly prevalent and aggressive disease. In the metastatic setting, major advances include the incorporation of immunotherapy and targeted therapies into the clinician's therapeutic armamentarium. Standard chemotherapeutic regimens have long been reported to interfere with the immune response to the tumor; conversely, antitumor immunity may add to the effects of those therapies. The aim of immunotherapy is to specifically enhance the immune response directed to the tumor. Recently, many trials addressed the role of such therapies for metastatic NSCLC treatment: ipilimumab, tremelimumab, nivolumab and lambrolizumab are immunotherapeutic agents of main interest in this field. In addition, anti-tumor vaccines, such as MAGE-A3, Tecetomide, TG4010, CIMAvax, ganglioside vaccines, tumor cell vaccines and dendritic cell vaccines, emerged as potent inducers of immune response against the tumor. The current work aims to address the most recent developments regarding these innovative immunotherapies and their implementation in the treatment of metastatic NSCLC. © 2014 Future Medicine Ltd.

Sampaio-Barros P.D.,University of Sao Paulo | Pereira I.A.,Federal University of Santa Catarina | Hernandez-Cuevas C.,National Autonomous University of Mexico | Berman A.,Hospital Angel Padilla | And 59 more authors.
Clinical and Experimental Rheumatology | Year: 2013

Objectives This study analysed the frequency of anterior uveitis (AU) and its correlations in a large cohort of patients with spondyloarthritis (SpA). Methods A common protocol of investigation was prospectively applied to 2012 SpA patients in 85 centres from 10 Ibero-American countries. Clinical and demographic variables and disease indexes were investigated. Categorical variables were compared by ?2 and Fisher's exact test, and continuous variables were compared by ANOVA or Kruskal-Wallis test. A value of p<0.05 was considered significant. Results AU was referred by 372 SpA patients (18.5%). AU was statistically associated with inflammatory low back pain (p<0.001), radiographic sacroiliitis (p<0.001), enthesopathies (p=0.004), urethritis/acute diarrhoea (p<0.001), balanitis (p=0.002), hip involvement (p=0.002), HLA-B27 (p=0.003), and higher C-reactive protein (p=0.001), whilst it was negatively associated with the number of painful (p=0.03) and swollen (p=0.005) peripheral joints, psoriatic arthritis (p<0.001), psoriasis (p<0.001), nail involvement (p<0.001), and dactilitis (p=0.062; trend). No association with gender, race, and indices (disease activity, functionality and quality of life) was observed. Logistic regression showed that ankylosing spondylitis (p=0.001) and HLA-B27 (p=0.083; trend) was significantly associated with AU, while extra-articular manifestations (predominantly psoriasis) were negatively associated (p=0.016). Conclusion Anterior uveitis is a frequent extra-articular manifestation in SpA patients, positively associated with axial involvement and HLA-B27 and negatively associated with peripheral involvement and psoriatic arthritis. © Copyright Clinical and Experimental Rheumatology 2013.

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