Hospital General Universitario Of Ciudad Real Ciudad Real

www.sescam.jccm.es.
Ciudad Real, Spain

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PubMed | Hospital General Universitario Of Ciudad Real Ciudad Real
Type: Journal Article | Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria | Year: 2015

to describe the efficacy and safety of the off-label use of alendronate in the treatment of osteoporosis in children and adolescents.a retrospective study (2008-2014) of all patients under 18 years who were dispensed alendronate for this indication. The criteria for initiating treatment were: bone mineral density with a Z-score -2.5 SD, a past history of bone fractures without a previous traumatism, and persistent pain. The variables collected were: demographic, treatment-related, clinical. and safety data. The treatment was considered to be effective when there was an increase in bone mineral density up to a Z-score > -2.5 SD.a total of 12 patients, 8 of them male, with a mean age of 11 years ( 3 SD), were treated with alendronate. After a mean time of treatment of 2.15 years ( 1.2 SD), there was an increase in bone mineral density in all patients, 9 of which achieved a Z-score > -2.5 SD, so the drug was considered effective in 75% of cases. No patient had bone fractures or expressed adverse effects during treatment.alendronate increased bone mineral density and was well tolerated in all patients, therefore it could be considered as a therapeutic option in the treatment of osteoporosis in children.

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