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San Sebastián de los Reyes, Spain

Heller S.L.,New York University | Garcia Santos J.M.,Hospital General Universitario Morales Meseguer
Radiologia | Year: 2011

Despite the proliferation of journals and the demanding responsibilities of an editorship, there are very few clearly delineated standards for editorial education. The editor of a medical journal has a challenging role. He or she must deal with scientific decisions and appraisals that require skill in both writing and critical review. But the editor also has to cope with other concerns, including ethical issues, opposition within the editorial board, and conflict with disgruntled authors. The editor has also to design the journal's future, and make decisions considering the strategic interest of the journal and the needs of the journal's readers. In this paper, we examine the medical editor's role, review the topic of education for those interested in medical editorial work and discuss the tenets and structure of existing medical editorial training programs. © 2010 SERAM. Published by Elsevier España, S.L. All rights reserved. Source

Mateos M.-V.,University of Salamanca | Hernandez M.-T.,Hospital Universitario Of Canarias | Giraldo P.,Hospital Universitario Miguel Servet | De La Rubia J.,San Vicente Martir Catholic University of Valencia | And 14 more authors.
New England Journal of Medicine | Year: 2013

BACKGROUND: For patients with smoldering multiple myeloma, the standard of care is observation until symptoms develop. However, this approach does not identify high-risk patients who may benefit from early intervention. METHODS: In this randomized, open-label, phase 3 trial, we randomly assigned 119 patients with high-risk smoldering myeloma to treatment or observation. Patients in the treatment group received an induction regimen (lenalidomide at a dose of 25 mg per day on days 1 to 21, plus dexamethasone at a dose of 20 mg per day on days 1 to 4 and days 12 to 15, at 4-week intervals for nine cycles), followed by a maintenance regimen (lenalidomide at a dose of 10 mg per day on days 1 to 21 of each 28-day cycle for 2 years). The primary end point was time to progression to symptomatic disease. Secondary end points were response rate, overall survival, and safety. RESULTS: After a median follow-up of 40 months, the median time to progression was significantly longer in the treatment group than in the observation group (median not reached vs. 21 months; hazard ratio for progression, 0.18; 95% confidence interval [CI], 0.09 to 0.32; P<0.001). The 3-year survival rate was also higher in the treatment group (94% vs. 80%; hazard ratio for death, 0.31; 95% CI, 0.10 to 0.91; P = 0.03). A partial response or better was achieved in 79% of patients in the treatment group after the induction phase and in 90% during the maintenance phase. Toxic effects were mainly grade 2 or lower. CONCLUSIONS: Early treatment for patients with high-risk smoldering myeloma delays progression to active disease and increases overall survival. Copyright © 2013 Massachusetts Medical Society. Source

Herrera Gimenez M.,Hospital General Universitario Morales Meseguer
Revista de Psiquiatria y Salud Mental | Year: 2011

Objective: The purpose of this article is to add to the knowledge of the neurobiology and aetiopathogenesis of bulimia nervosa, a common disorder in routine clinical practice. To do this, we will study decision making in low risk and low uncertainty patients. Material and methods: The study consisted of 19 females who fulfilled the diagnostic criteria of bulimia nervosa according to the DSM-IV and a control group of 28 healthy female students from the Faculty of Psychology. They performed two tasks: one a "cups task" risk and the other an "ambiguity task", both associated with emotions and decision making. Results: The patients with bulimia took more risks in the win domain than in the lose domain, whereas the reverse was observed in the control group. In the decision making task, low ambiguity, and the number of decisions risked, was similar in both bulimia nervosa and the control group. Conclusions: Our results support those of previous investigations and theories that postulate that the making of decisions is not only mediated by cognitive processes, but the emotions also play an important role in these processes. © 2010 SEP y SEPB. Published by Elsevier España, S.L. All rights reserved. Source

Garcia Santos J.M.,Hospital General Universitario Morales Meseguer
Radiologia | Year: 2011

The reviewer's job is fundamental to the editorial process in a scientific journal. The quality of the review will determine the quality of the journal. Therefore, it is very important for the reviewers to make this mission their own and to contribute to the development of science and of the journal. On the other hand, the focus of a review will depend largely on the type of journal for which one is reviewing. In this article, we explain what the journal Radiología, the scientific journal of the Spanish Society of Medical Radiology, expects of its reviewers and their reviews of original articles. We aim to establish some basic rules to lay the groundwork for the development of more detailed guidelines for reviewing articles for the journal Radiología. © 2011 SERAM. Published by Elsevier España, S.L. All rights reserved. Source

Mercader P.,Hospital General Universitario Morales Meseguer
Advances in Experimental Medicine and Biology | Year: 2010

Abstract Muir-Torre syndrome (MTS) is an autosomal dominant genodermatosis that consists of unusual cutaneous sebaceous neoplasm, with or without kerathoacantomas and one or more low-grade visceral malignancies, with or without colonic polyps, in the absence of other predisposing factors. This chapter presents a review of the principal clinical and genetic findings in this syndrome and discusses its relation with Lynch syndrome. © 2010 Landes Bioscience and Springer Science+Business Media. Source

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