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Gomez L.M.,Ramon y Cajal Hospital | Bagazgotia L.,Ramon y Cajal Hospital | Requena L.,Fundacion Jimenez Diaz Hospital
International Journal of Trichology | Year: 2015

Woolly hair nevus is a rare disease whose diagnosis is challenging. We present a case of this condition presenting in a 27-year-old healthy male. We describe a histology pattern consisting in the presence of several terminal hair follicles ending in the same dilated follicular infundibulum, a perifollicular lymphocytic infiltrate and an excessive amount of normal apocrine glands in deep reticular dermis, some findings non-previously reported. Clinicopathological correlation is very important for making a correct diagnosis. Source


Benson G.,Mount Sinai School of Medicine | De Felipe J.,Fundacion Jimenez Diaz Hospital | De Felipe J.,Camilo Jose Cela University | Xiaodong,Mount Sinai School of Medicine | And 3 more authors.
Alzheimer's and Dementia | Year: 2014

Background Spanish is the second-most common language spoken in the United States, and Spanish speakers represent one third of the aging population. The National Alzheimer's Coordinating Center's Uniform Data Set implemented a Spanish neuropsychological battery. Previous work described the neuropsychological performance for English speakers. Here we describe performance on the Spanish version.Methods Data from 276 Spanish speakers with normal cognition were summarized, with descriptive tables of performance on individual cognitive tests. Regression techniques were used to evaluate the effect of demographics on cognitive performance.Results Spanish speakers were younger (70.0 vs 74.0 years) and less educated (10.7 vs 15.7 years) with more females (76% vs 63% female) than the previously described English speakers. Higher education and lower age were associated with better performance.Conclusion This national cohort of well-characterized Spanish-speaking elders provides descriptive data on cognitive performance, an important tool for clinical and research efforts. © 2014 The Alzheimer's Association. Source


James A.H.,Duke University | Kouides P.A.,Rochester General Hospital | Abdul-Kadir R.,Royal Free Hospital | Dietrich J.E.,Baylor College of Medicine | And 10 more authors.
European Journal of Obstetrics Gynecology and Reproductive Biology | Year: 2011

Acute menorrhagia is a common gynecological disorder. Prevalence is high among women with inherited bleeding disorders and recent guidance for optimal management is lacking. Following a comprehensive review of the literature, an international expert panel in obstetrics, gynecology and hematology reached consensus on recommendations regarding the management of acute menorrhagia in women without a diagnosed bleeding disorder, as well as in patients with von Willebrand disease, platelet function disorders and other rare hemostatic disorders. The causes and predictors of acute menorrhagia are discussed and special consideration is given for the treatment of women on anticoagulation therapy. This review and accompanying recommendations will provide guidance for healthcare practitioners in the emergency management of acute menorrhagia. © 2011 Elsevier Ireland Ltd. Source


Servan P.R.,Fundacion Jimenez Diaz Hospital
Nutricion Hospitalaria | Year: 2013

Type 2 diabetes mellitus is characterized by hyperglycemia, insulin resistance, and relative impairment in insulin secretion and its possible long term complications. Its pathogenesis is poorly understood, but both genetic and environmental factors, such as obesity and aging, play a key role. "Diabesity" is a new term which refers to diabetes occurring in the context of obesity. In this article, we will discuss the epidemiology and impact of diabetes and obesity and will also outline the components of the metabolic syndrome and the studies that demonstrate that screening and prevention are possible in an attempt to control this epidemic. Source


Carcas A.J.,Autonomous University of Madrid | Borobia A.M.,Autonomous University of Madrid | Velasco M.,Autonomous University of Madrid | Abad-Santos F.,Autonomous University of Madrid | And 4 more authors.
Trials | Year: 2012

Background: Hemorrhagic events are frequent in patients on treatment with antivitamin-K oral anticoagulants due to their narrow therapeutic margin. Studies performed with acenocoumarol have shown the relationship between demographic, clinical and genotypic variants and the response to these drugs. Once the influence of these genetic and clinical factors on the dose of acenocoumarol needed to maintain a stable international normalized ratio (INR) has been demonstrated, new strategies need to be developed to predict the appropriate doses of this drug. Several pharmacogenetic algorithms have been developed for warfarin, but only three have been developed for acenocoumarol. After the development of a pharmacogenetic algorithm, the obvious next step is to demonstrate its effectiveness and utility by means of a randomized controlled trial. The aim of this study is to evaluate the effectiveness and efficiency of an acenocoumarol dosing algorithm developed by our group which includes demographic, clinical and pharmacogenetic variables (VKORC1, CYP2C9, CYP4F2 and ApoE) in patients with venous thromboembolism (VTE).Methods and design: This is a multicenter, single blind, randomized controlled clinical trial. The protocol has been approved by La Paz University Hospital Research Ethics Committee and by the Spanish Drug Agency. Two hundred and forty patients with VTE in which oral anticoagulant therapy is indicated will be included. Randomization (case/control 1:1) will be stratified by center. Acenocoumarol dose in the control group will be scheduled and adjusted following common clinical practice; in the experimental arm dosing will be following an individualized algorithm developed and validated by our group. Patients will be followed for three months. The main endpoints are: 1) Percentage of patients with INR within the therapeutic range on day seven after initiation of oral anticoagulant therapy; 2) Time from the start of oral anticoagulant treatment to achievement of a stable INR within the therapeutic range; 3) Number of INR determinations within the therapeutic range in the first six weeks of treatment.Discussion: To date, there are no clinical trials comparing pharmacogenetic acenocoumarol dosing algorithm versus routine clinical practice in VTE. Implementation of this pharmacogenetic algorithm in the clinical practice routine could reduce side effects and improve patient safety.Trial registration: Eudra CT. Identifier: 2009-016643-18. © 2012 Carcas et al.; licensee BioMed Central Ltd. Source

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