Anthropometric indexes predicting cardiometabolic risk. Prospective cohort study in a population of employees of public hospitals [Índices antropométricos predicen riesgo cardiometabólico. Estudio de cohorte prospectivo en una población de empleados de hospitales públicos]
Sanchez A.,Hospital Provincial Of Pediatria Dr Fernando Barreyro |
Sanchez A.,National University of Misiones |
Muhn M.A.,National University of Misiones |
Muhn M.A.,Hospital Dr Ramon Madariaga |
And 10 more authors.
Revista Argentina de Endocrinologia y Metabolismo | Year: 2014
In recent decades, a significant increase has been observed in noncommunicable chronic diseases associated with unhealthy lifestyles, with obesity being a chronic disease in itself and at the same time a recognized risk factor for many other conditions. The aim of this study is to assess the predictive value of body mass index (BMI), waist circumference and waist index / height for the development of high blood pressure (hypertension), high cholesterol and type 2 diabetes (DM2) in a cohort of public hospital employees from Posadas, Misiones, who were followed up from 2002 to 2012. Of the total population of 989 public employees, we selected 259 subjects with normal blood pressure, no hypercholesterolemia and no diabetes at baseline. Personal interviews, anthropometric and blood pressure measurements were performed and blood samples were collected after a 12-hour fast. For the event analysis, the Cox proportional hazards model was used, calculating the corresponding Hazard Ratio (HR) adjusted for age and sex. BMI significantly predicted the development of hypertension (HR: 1.100, CI: 1.054 to 1.148, p < 0.001) and DM2 (HR: 1.253, CI: 1.122 to 1.40, P < 0.001). The waist circumference was associated with hypertension (HR: 2.273, CI: 1.465 to 3.826, p < 0.001) and DM2 (HR: 5.578, CI: 1.247 to 24.92, p = 0.024). The waist / height ratio significantly predicted the development of hypertension (HR: 2.173, CI: 1.438 to 3.283, p < 0.001) and DM2 (HR: 5.875, CI: 1.140 to 30.28, p = 0.034). None of the indicators of obesity evaluated was significantly associated with the development of hypercholesterolemia. We conclude that BMI, waist circumference and waist / height ratio predicted the development of hypertension and type 2 diabetes. This underlines the usefulness of these indicators for monitoring the above-referred conditions by traditional anthropometric measurements. Copyright ® 2014 por la Sociedad Argentina de Endocrinología y Metabolismo
Births prevalence of 27 selected congenital anomalies in 7 geographic regions of Argentina [Prevalencia al nacimiento de 27 anomalías congénitas seleccionadas, en 7 regiones geográficas de la Argentina]
Campana H.,Instituto Multidisciplinario Of Biologia Celular Imbice |
Pawluk M.S.,Instituto Multidisciplinario Of Biologia Celular Imbice |
Lopez Camelo J.S.,Instituto Multidisciplinario Of Biologia Celular Imbice |
Carvallo I.G.,Hospital Fernandez |
And 60 more authors.
Archivos Argentinos de Pediatria | Year: 2010
Objective. The aim of the present work was to estimate the frequency of 27 birth defects in 7 geographical regions of Argentina. Material and methods. Observational, cross-sectional, descriptive design. A sample of 21,844 new born with birth defects was selected, ascertained from 855,220 births, between 1994 and 2007, in 59 hospitals belonging to the ECLAMC network. In order to identify regions of high frequency a Poisson regression was used, adjusted by different hospitals from the same region. The model included a time variable to detect secular trends and 6 dummy variables for 7 predefined geographical regions: Metropolitana (MET); Pampa (PAM); Centro (CEN); Cuyo (CUY); Noroeste (NOA); Nordeste (NEA) and Patagonia (PAT). Results. High frequencies regional analysis showed the following significant results: PAM: severe hypospadias; CEN: spina bifida, microtia, cleft lip with cleft palate, polycystic kidney, postaxial polydactyly and Down syndrome; CUY: postaxial polydactyly; NOA: omphalocele, gastroschisis, cleft lip without cleft palate, cleft lip with cleft palate, anorectal atresia/stenosis, indeterminate sex, preaxial polydactyly and pectoral agenesis; PAT: cleft lip without cleft palate. Conclusion. Out of the 27 congenital anomalies analyzed, fourteen showed a frequency significatively higher in one or more regions.
Pedrozo W.R.,Hospital Dr Ramon Madariaga |
Bonneau G.,Hospital Dr Ramon Madariaga |
Castillo Rascon M.S.,Hospital Dr Ramon Madariaga |
Juarez M.,Hospital Dr Ramon Madariaga |
Cardozo J.,Hospital Dr Ramon Madariaga
Archivos Argentinos de Pediatria | Year: 2010
Introduction. Altered lipid metabolism along with other cardiovascular risk factors promotes atherosclerosis at early age, leading to cardiovascular disease development. We aimed to estimate the prevalence of abnormal lipid profile in school adolescents from the city of Posadas, Misiones, Argentina, and describe the distribution of values in an apparently healthy subgroup. Population and methods. Descriptive cross-sectional study in a sample of students from 12 to 18 years of age. We obtained personal data, anthropometric measurements and a blood sample with 12 hours fasting for lipid determinations. Lipid profile percentiles were determined in a subgroup of apparently healthy adolescents. Results. We studied 523 adolescents. We found cholesterolemia ≥200 mg/dL in 7.8%, total cholesterol between 170 and 199 mg/dL in 18.7%; triglyceridemia >110 mg/dl in 20.1% and HDL cholesterol <40 mg/dl in 17.0%. In the stratification by sex and age, males aged 15-18 years showed a higher prevalence of HDL cholesterol decreased (27.3%; p= 0.02). We found a more atherogenic lipid profile in overweight or obese adolescents than in those with normal weight or underweight. In the subgroup of 354 apparently healthy adolescents, the 75th percentile values were: total cholesterol 171 mg/dL, triglycerides 96 mg/dL, LDL cholesterol 102 mg dL, HDL cholesterol 117 mg/dL, total cholesterol/HDL cholesterol 3.48 and triglyceride/HDL cholesterol of 2.01. The 5th percentile for HDL cholesterol was 35 mg/dL. Conclusion. There was a high prevalence of lipid abnormalities. Lipid profile values were similar to those described in other populations of adolescents aged 12-18 yr, except triglyceride.
Lipid profile and uric acid in hypertensive pregnant women in Madariaga Hospital, Posadas, Misiones [Perfil lipídico y ácido úrico en embarazadas hipertensas del Hospital Madariaga, Posadas, Misiones]
Lopez D.L.,Hospital Dr Ramon Madariaga |
Rascon M.S.C.,Hospital Dr Ramon Madariaga |
Bonneau G.A.,Hospital Dr Ramon Madariaga |
Ywaskiewicz R.,Hospital Dr Ramon Madariaga |
And 2 more authors.
Acta Bioquimica Clinica Latinoamericana | Year: 2010
The lipid profile and uric acid were evaluated in pregnant women who suffer high blood pressure in the first three-month period of pregnancy, treated sequentially in the Obstetric Service of Madariaga Hospital form February to June, 2009. Thirty-one hypertense pregnant women and fifty-eight pregnant women with normal blood pressure were studied. Both groups were between 20 and 35 years old and their body mass index was between 18.5-29.9 kg/m 2 before pregnancy. Personal, gynecological-obstetric and family data were recorded. Venous blood was extrated after 12 hours of fasting for biochemical determinations, which were analyzed through enzymatic colorimetric methods with internal and external quality controls. Hypertensive pregnant women versus pregnant women with normal blood pressure presented triglycerides (261±238 vs 196.8±90.6, p=0.01), VLDL-Chol (49.07± 23.75 vs 39.52± 16.19, p=0.04), triglycerides/HDL-Chol (5.45±4.1 vs 3.57±1.77, p=0.031), uric acid (40.57±10.49 vs 55.64±20.26, p<0.001) no important differences were found for total cholesterol, HDL-Chol, no-HDL-Chol, LDL-Chol and Chol/HDL-Chol. The systolic blood pressure correlated in a significant way with most of the lipid parameters and uric acid. On multivariate analysis, uric acid, VLDL-chol and FAHTA account for 40% of the variation in systolic blood pressure. The inclusion of the lipid profile and uric acid in hypertensive pregnant women's biochemical evaluation is suggested because they are accessible in low complexity laboratories and they would contribute to the evaluation of endothelium damage caused by transient high blood pressure.