Hospital de Órbigo, Spain
Hospital de Órbigo, Spain

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Velasco Garcia M.J.,Na Sa de Sonsoles Hospital | Cobeta I.,Ramon y Cajal University Hospital | Martin G.,Na Sa de Sonsoles Hospital | Alonso-Navarro H.,Del Sureste Hospital | Jimenez-Jimenez F.J.,Del Sureste Hospital
Journal of Voice | Year: 2011

Background/Objectives: Alterations of voice and speech are frequently observed in Huntington's disease (HD). The aim of this study was to assess the degree of voice and speech abnormalities in a group of patients with HD and to analyze possible correlations with degree of disease severity. Patients/Methods: An observational study was carried out on diagnosed cases and controls. The voices of 20 patients were analyzed and compared with an age- and sex-matched control group. Variables analyzed included subjective voice exploration, analysis of aerodynamic efficiency, acoustic analysis measures, and laryngeal examination descriptions. Results obtained were correlated with degree of disease severity. Results: Changes in the Voice Handicap Index and clinical characteristics of the voice were observed. Maximum phonation time was reduced. Acoustic analysis revealed changes that were analyzed. Uncontrolled adduction-abduction movements were observed by laryngeal examination. All results showed a positive correlation with degree of disease severity assessed by the Unified Huntington's Disease Rating Scale. Conclusions: HD causes alterations in subjective voice features, aerodynamic and acoustic analysis measures that are correlated with disease severity. © 2011 The Voice Foundation.


Mate M.A.,Fundacion Alcorcon University Hospital | Cobeta I.,Ramon y Cajal University Hospital | Jimenez-Jimenez F.J.,Del Sureste Hospital | Figueiras R.,Ramon y Cajal University Hospital
Journal of Voice | Year: 2012

Introduction: An acoustic analysis was conducted of the voice of 25 patients with Parkinson's disease (PD) subjected to deep brain stimulation (DBS) to assess the impact of therapy. Materials and Methods: We examined 25 patients with advanced PD under four different conditions: deprived of medical treatment, under medical treatment, and one week and one month after the implant of the DBS electrodes. At the four time points, the patients produced a sustained /a/ and a standard sentence in Spanish, and microphone and electroglottographic recordings were digitally analyzed using the Computerized Speech Lab program. Results: Waveform analysis of the sustained /a/ captured by the microphone indicated a higher fundamental frequency (F0) when the patients were under levodopa treatment. The frequency perturbation (jitter) decreased remarkably after the three treatments. Shimmer also fell, but differences were not significant. Conclusions: Nearly all acoustic analysis parameters during phonation of a sustained /a/ improved after DBS, but the factor that was most sensitive to the impact of both surgical and medical therapy was jitter. © 2012 The Voice Foundation.

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