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Las Palmas de Gran Canaria, Spain

Gentille Lorente D.I.,Hospital de Tortosa Verge de la Cinta
Revista de la Federacion Argentina de Cardiologia | Year: 2016

One-stop shop is an ambulatory healthcare modality that speeds up the diagnostic and therapeutic process; it is, in a single act, visits and the required diagnostic tests that are performed. The results of a cardiology one-stop shop are analyzed through a retrospective study with analytical component of 215 patients visited in a one-stop shop since its creation, corresponding to the 7.7% of the all first visits of that period. The mean age of patients is 60.3 ± 16.6 years, 54% are from primary care and up to 51.2% are due to palpitations / arrhythmias. An electrocardiogram is performed in 100% and an echocardiogram to 89.8%; 86.5% of the patients have only one test in addition to the electrocardiogram. The average length of consultation is 109.4 ± 45.9 min, reaching a diagnosis in all cases and treatment is started/modified in 52.6%. 26% of patients are cardiologically discharged and 72.1% are scheduled for a second visit. The degree of satisfaction in patients and cardiologists is high. © 2016, Federacion Argentina de Cardiologia. All rights reserved. Source


De La Cruz-Merino L.,Hospital Universitario Virgen Macarena | Alvaro T.,Hospital de Tortosa Verge de la Cinta | Henao-Carrasco F.,Hospital Universitario Virgen Macarena | Villar Rodriguez J.L.,Hospital Universitario Virgen Macarena | And 3 more authors.
Journal of Biomedicine and Biotechnology | Year: 2010

Lymphomas represent a wide group of heterogenic diseases with different biological and clinical behavior. The underlying microenvironment-specific composition seems to play an essential role in this scenario, harboring the ability to develop successful immune responses or, on the contrary, leading to immune evasion and even promotion of tumor growth. Depending on surrounding lymphoid infiltrates, lymphomas may have different prognosis. Moreover, recent evidences have emerged that confer a significant impact of main lymphoma's treatment over microenvironment, with clinical consequences. In this review, we summarize these concepts from a pathological and clinical perspective. Also, the state of the art of lymphoma's anti-idiotype vaccine development is revised, highlighting the situations where this strategy has proven to be successful and eventual clues to obtain better results in the future. © 2010 Toms lvaro et al. Source


Roszkowiak L.,Nalecz Institute of Biocybernetics and Biomedical Engineering | Korzynska A.,Nalecz Institute of Biocybernetics and Biomedical Engineering | Lejeune M.,Molecular Biology and Research Section | Bosch R.,Hospital de Tortosa Verge de la Cinta | Lopez C.,Molecular Biology and Research Section
Advances in Intelligent Systems and Computing | Year: 2016

We present the METINUS (METhod of Immunohistochemical NUclei Segmentation), which is a improved and modified version of supporting tool for pathologists from 2010. The method supports examination of immunohistochemically stained thin tissue sections from biopsy of follicular lymphoma patients. The software localizes and counts FOXP3 expression in the cells’ nuclei supporting standard procedure of diagnosis and prognosis. The algorithm performs colour separation followed by object extraction and validation. Objects with statistical parameters not in specified range are disqualified from further assessment. To calculate the statistics we use the following: three channels of RGB, three channels of Lab colour space, brown channel and three layers completed with colour deconvolution. Division of the objects is done with support of watershed and colour deconvolution algorithm. Evaluation was performed on arbitrarily chosen 20 images with moderate quality of most typical tissues. We compared results of improved method with the previous version in the context of semiautomatic, pathologist controlled, computer-aided result of quantification as reference. Comparison is based on quantity of nuclei located per image using Kendall’s tau-b correlation coefficient. It shows concordance of 0.91 between results of proposed method and reference, while with previous version it is only 0.71. © Springer International Publishing Switzerland 2016. Source


Gentille Lorente D.I.,Hospital de Tortosa Verge de la Cinta
Insuficiencia Cardiaca | Year: 2014

Aneurysms of the pulmonary arteries (APA) are rare vascular anomaly is difficult to diagnose because of its low prevalence and its clinical absent or nonspecific, which often makes their discovery is casual during an imaging or autopsy. Up to 50% of such aneurysms are associated with congenital heart disease, while others are related to various diseases, and in many of the cases are also detected pulmonary hypertension, however, are exceptionally idiopathic. Among some possible complications can be fatal, especially rupture, which usually presents with severe hemoptysis and even sudden death. Imaging tests such as echocardiography and computerized mainly tomography and magnetic resonance imaging allow diagnosis in most cases. Currently, the management of APA is controversial so that, based on the best scientific evidence available and the lack of clear recommendations must be individualized in each case. © 2014 Silver Horse. Source


De La Cruz-Merino L.,Hospital Universitario Virgen Macarena | Lejeune M.,Molecular Biology and Research Section | Nogales Fernandez E.,Hospital Universitario Virgen Macarena | Henao Carrasco F.,Hospital Universitario Virgen Macarena | And 5 more authors.
Clinical and Developmental Immunology | Year: 2012

Hodgkin's lymphoma represents one of the most frequent lymphoproliferative syndromes, especially in young population. Although HL is considered one of the most curable tumors, a sizeable fraction of patients recur after successful upfront treatment or, less commonly, are primarily resistant. This work tries to summarize the data on clinical, histological, pathological, and biological factors in HL, with special emphasis on the improvement of prognosis and their impact on therapeutical strategies. The recent advances in our understanding of HL biology and immunology show that infiltrated immune cells and cytokines in the tumoral microenvironment may play different functions that seem tightly related with clinical outcomes. Strategies aimed at interfering with the crosstalk between tumoral Reed-Sternberg cells and their cellular partners have been taken into account in the development of new immunotherapies that target different cell components of HL microenvironment. This new knowledge will probably translate into a change in the antineoplastic treatments in HL in the next future and hopefully will increase the curability rates of this disease. © 2012 Luis de la Cruz-Merino et al. Source

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