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Gutiérrez Zamora, Mexico

Rosales R.,Virolab | Lopez-Contreras M.,Hospital de Cuautitlan | Rosales C.,National Autonomous University of Mexico | Magallanes-Molina J.-R.,Sanatorio San Francisco | And 9 more authors.
Human Gene Therapy

Human papilloma viruses can induce warts, condylomas, and other intraepithelial cervical lesions that can progress to cancer. Cervical cancer is a serious problem in developing countries because early detection is difficult, and thus proper early treatment is many times missing. In this phase III clinical trial, we evaluated the potential use of MVA E2 recombinant vaccinia virus to treat intraepithelial lesions associated with papillomavirus infection. A total of 1176 female and 180 male patients with intraepithelial lesions were studied. They were injected with 107 MVA E2 virus particles directly into their uterus, urethra, vulva, or anus. Patients were monitored by colposcopy and cytology. Immune response was determined by measuring the antibody titer against MVA E2 virus and by analyzing the cytotoxic activity against cancer cells bearing papillomavirus DNA. Papillomavirus was determined by the Hybrid Capture method or by polymerase chain reaction analysis. By histology, 1051 (89.3%) female patients showed complete elimination of lesions after treatment with MVA E2. In 28 (2.4%) female patients, the lesion was reduced to CIN 1. Another 97 (8.3%) female patients presented isolated koilocytes after treatment. In men, all lesions were completely eliminated. All MVA E2-treated patients developed antibodies against the MVA E2 vaccine and generated a specific cytotoxic response against papilloma-transformed cells. Papillomavirus DNA was not detected after treatment in 83% of total patients treated. MVA E2 did not generate any apparent side effects. These data suggest that therapeutic vaccination with MVA E2 vaccine is an excellent candidate to stimulate the immune system and generate regression in intraepithelial lesions when applied locally. © Mary Ann Liebert, Inc. 2014. Source

Introduction: there are certain factors that influence the early cessation of breastfeeding among which are the demographic, cultural, biological and psychological. Objective: to analyze sociodemographic factors influencing the abandonment of breastfeeding in a support group to it. Methodology: descriptive, prospective, observational, cross-sectional study at the Hospital for Women in Morelia Michoacán, from September to November 2014, a total of 86 women in the postpartum period gynecology floor. Results: the reasons why the LME is abandoned are: age under 25 years (19.1%), urban locality (16.9%), and marital cohabitation (15.7%), and work (9%). Conclusions: most of the women had that age, education level and location are the main factors that influence as to abandon breastfeeding before the recommended time. © 2015, Grupo Aula Medica S.A. All rights reserved. Source

Garcia Rojas Vazquez L.E.,Universidad Michoacana de San Nicolas de Hidalgo | Trujano-Ramos L.A.,Hospital de la Mujer | Perez-Rivera Y.E.,Servicio de OncoHematologia del Hospital Eva Samano de Lopez Mateos
Nutricion Hospitalaria

The head and neck cancer in Michoacán, Mexico, ranks as the third most common cancer and accounts for 12% of deaths. The increase in malnutrition in a patient with this disease has been associated with increased mortality. Material and methods: We studied prospectively 30 patients of both sexes, aged 18 years with head and neck cancer in the Cancer Care Center of Michoacan. In the evaluation period since August 2010 to August 2011. Formats were used VGS-Oncology (Subjective Global Assessment), NRS 2002 (Nutritional risk screen) and Guss (Gugging Swallowing Screen), through which nutritional risk was determined, and established the swallowing capacity of the study population. Results: In our study, 53.3% of the population had moderate malnutrition according to the VGS Oncology, 33% weight loss record. The NRS 2002 show that 43.3% is at risk of malnutrition. The degree of dysphagia is shown more often in older patients, cancer type and stage of illness. Conclusions: Nutritional risk scales relate directly proportional to tumor location and stage, as well, there are other different oncological factors involved in the patient's nutritional deterioration. Therefore it is of vital importance to have a nutritionist as part of the multidisciplinary team, to detect the nutritional risk and to be able to handle it in an opportune way. Source

Ponce-Monter H.,Autonomous University of the State of Hidalgo | Fernandez-Martinez E.,Autonomous University of the State of Hidalgo | Ortiz M.I.,Autonomous University of the State of Hidalgo | Ramirez-Montiel M.L.,Hospital de la Mujer | And 3 more authors.
Journal of Smooth Muscle Research

Aloysia triphylla is traditionally utilized for the treatment of menstrual colic (primary dysmenorrhea) in Mexico. Citral is the main chemical component found in Aloysia triphylla leaves extract. Primary dysmenorrhea is a very frequent gynecological disorder in menstruating women, affecting 30-60% of them. It is usually treated with non-steroidal antiinflammatory drugs (NSAIDs); although their effect is rapid, they possess many side effects. Due to these shortcomings, Mexican folk therapy is considered as a feasible alternative. The effects of the hexane extract of Aloysia triphylla and citral on uterine contractions were evaluated in vitro as well as their anti-inflammatory properties and gastric wound capabilities were assessed in vivo. The inhibitory effects on the contractions were analyzed using isolated uterus strips from estrogen primed rats. Contractions were induced by KCl 60 mM, oxytocin 10 mIU/mL, charbacol 10 μM and PGF2a 5 μM. The anti-inflammatory effect was assessed on carrageenan-induced rat hind paw edema model. The inhibitory concentration-50 (IC50) of the hexane extract of Aloysia triphylla upon each contractile response was for KCl 44.73 ± 2.48/μg/mL, oxytocin 42.16 ± 3.81/μg/mL, charbacol 41.87 ± 1.73/μg/mL and PGF2α 28.70 ± 2.40/μg/mL in a concentration-dependent way. The extract of Aloysia triphylla produced a significant inhibitory effect on PGF2c-induced contraction compared to its inhibitory actions on the others. Citral exhibited the same inhibitory effect on the contraction induced by PGF2α. The oral administration of the extract (100-800 mg/kg) and citral (100-800 mg/kg) showed anti-inflammatory activity; furthermore, the maximal dose utilized did not produce gastric injury. These results were compared with anti-inflammatory effects and gastric damage produced by 30 mg/kg of indomethacin p.o. The spasmolytic and anti-inflammatory effects support the traditional use of Aloysia triphylla leaves in the treatment of the primary dysmenorrhea in Mexican communities. Source

Rodriguez-Dennen F.,Institute Oftalmologia Fundacion Conde Of Valenciana | Martinez-Ocana J.,Hospital General Dr. Manuel Gea Gonzalez | Kawa-Karasik S.,Hospital General Dr. Manuel Gea Gonzalez | Villanueva-Egan L.,Hospital de la Mujer | And 3 more authors.
BMC Pregnancy and Childbirth

Background: Pregnancy is accompanied by several hemodynamic, biochemical and hematological changes which revert to normal values after labor. The mean values of these parameters have been reported for developed countries, but not for Mexican women. Furthermore, labor constitutes a stress situation, in which these factors may be altered. It is known that serologic increase of heat shock protein (Hsp) 70 is associated with abnormal pregnancies, presenting very low level in normal pregnant women. Nevertheless, there are no studies where these measurements are compared in healthy pregnant women at their third trimester of pregnancy (3TP) and the active labor phase (ActLP).Methods: Seventy five healthy Mexican pregnant women were included. Hemodynamic, biochemical and hematological parameters were obtained in all cases, and serum Hsp70 levels were measured in a sample of 15 women at 3TP and at ActLP.Results: Significant differences were found in most analysis performed and in Hsp70 concentration at 3TP as compared to ActLP, however all were within normal range in both conditions, supporting that only in pathological pregnancies Hsp70 is drastically increased.Conclusion: Results obtained indicate that 3TP and ActLP have clinical similarities in normal pregnancies, therefore if abnormalities are found during 3TP, precautions should be taken before ActLP. © 2011 Rodríguez-Dennen et al; licensee BioMed Central Ltd. Source

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