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Introduction and aims. The School of Salerno stood as a landmark in the teaching and practice of medicine in the Western mediaeval world. Women could be both teachers and students and made significant contributions to its abundant scientific production. One of the most important of such women was Trotula of Salerno, the 12th century author of the Passionibus mulierum curandorum. De secretis mulierum, de chirurgia et de modo medendi libri septem is an anonymous medical poem from the School of Salerno, which was discovered in a manuscript from the 13th century. It consists of seven books and 7280 dactylic hexameters. The first book is specifically devoted to women's diseases and the second is a treaty on cosmetics. Books III and IV deal with surgery and follow the classical a capite ad calcem formula. The seventh book, De modo medendi, deals with therapeutics. We review the references to neurological diseases, using a critical translation of this text to carry out our study. Development. The poem proposes therapies to treat epilepsy, headache or tinnitus. The treatment to be prescribed for headache differs depending on its origin. It puts forward pathophysiological explanations for the different types of headache, it relates engorged blood vessels with hemicranial headache, and suggests an excess of phlegm as the origin of mild occipital headache. Conclusions. Neurological pathology is well represented in this mediaeval monograph on women's diseases. Furthermore, it also shows us the vision that the Salerno physician has of these conditions and the therapeutic arsenal (based mainly on medicinal plants) that was available for use. © 2010 Revista de Neurología. Source

Molina Vazquez M.E.,Hospital Clinico Universitario Of Valladolid
Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica | Year: 2011

Minimally invasive surgery (CMI) for the treatment of malignant tumors in children begins to have a role for selected cases and reaches similar results than open surgery. We show our first two cases of Wilms tumor treated by laparoscopy describing patients and technique. Three-year-old girl with macroscopic hematuria is diagnosed of 8 cm mass in the left kidney suggesting Wilms tumor. After 4 weeks of chemotherapy she went under laparoscopic nephroureterectomy. The histological result was Wilms tumor. Chemotherapy was completed seven more months. Five-year-old patient with abdominal pain is diagnosed of renal right mass suggesting Wilms tumor. After 4 weeks of chemotherapy the laparoscopic nephroureterectomy was performed. The histological result was Wilms tumor. Treatment was completes with postoperatory chemotherapy. After 1 year follow-up both patients have clinical and radiological absence of disease. The CMI in selected cases of Wilms tumor fulfills successfully the aims of the surgical treatment. Source

De Cabanyes Candela S.,Hospital Clinico Universitario Of Valladolid | Detterbeck F.C.,Yale Cancer Center Thoracic Oncology Program
Journal of Thoracic Oncology | Year: 2010

Background: Many clinicians use restaging after induction therapy as a way to select patients for surgery. Methods: A systematic review was conducted to define the reliability of restaging tests after induction therapy for stage III(N2) lung cancer, when compared with pathologic findings at surgery. Results: A complete response at all sites carries a false-negative (FN) rate of 50% for computed tomography and 30% for positron emission tomography. Mediastinal node involvement has FN and false-positive rates of 33% and 33% by computed tomography, and 25% and 33% by positron emission tomography. The FN rate of invasive restaging is 22% by repeat mediastinoscopy, 14% by esophageal ultrasound and needle aspiration in expert hands (reliable Results are not yet available for endobronchial ultrasound), and 9% by primary mediastinoscopy done with optimal thoroughness. These Results are not significantly affected by the type of induction therapy or the timing of restaging. Conclusion: The ability to identify patients who have achieved mediastinal downstaging other than by a careful primary mediastinoscopy is poor. Copyright © 2010 by the International Association. Source

Dabus G.,Baptist Cardiac and Vascular Institute | Linfante I.,Baptist Cardiac and Vascular Institute | Martinez-Galdamez M.,Hospital Clinico Universitario Of Valladolid
Clinical Neurology and Neurosurgery | Year: 2014

Objective We report our results of our experience using transarterial balloon-assisted embolization of aggressive DAVFs using a dual lumen balloon microcatheter. The advantages and disadvantages of this technique when compared to different Onyx embolization techniques are discussed. Patients and methods All patients with aggressive DAVFs who were treated with Onyx using transarterial balloon-assisted technique with a dual lumen balloon microcatheter were included. Clinical presentation, location of DAVF, Borden type, dual lumen balloon microcatheter used, amount of Onyx used, Onyx injection duration, complications, immediate angiographic and follow up results were included in the analysis. Results Five patients fulfilled the selection criteria. Their ages ranged from 24 to 62 years old. In 4 cases the dual lumen balloon microcatheter was a Scepter-C 4 mm × 10 mm (Microvention, Tustin, CA); in the other patient the device used was an Ascent 4 mm × 10 mm (Codman, Raynham, MA). In all 5 patients the dual lumen balloon microcatheter was used with the objective to cure the lesion and it was successful in all 5 cases. There was no vessel injury, unwanted embolization, retained microcather, microcatheter rupture or cranial nerve deficits in our series. Our mean Onyx injection time was 6.4 min (range from 2 to 10 min). There were no procedural complications in our series. Four out of 5 patients had angiographic follow up demonstrating persistent angiographic cure (follow up mean 6 months - range 4-7 months). Conclusions Our experience in this small series of patients indicates that the use of dual lumen balloon microcatheters is safe and feasible, facilitating the use of Onyx for embolization of DAVFs. © 2013 Elsevier B.V. Source

Aller R.,Hospital Clinico Universitario Of Valladolid | Izaola O.,Hospital Clinico Universitario
Nutricion Hospitalaria | Year: 2014

In the nutritional management of patients with dysphagia and/or elderly must make a multidisciplinary approach and a main tool is changing the texture of food. Patients with dysphagia, who need a texture modified diet, generally do not have a calorie and nutrient requirements different from those exhibited by people of the same age and sex, unless a condition or disease coexist. In these patients, Texture of foods should be individualized according to the patient and the time course of their disease. The use of texture modified diets without specifying produces a clear decrease in caloric and protein intakes and nutritional disorders. These patients may have other characteristics associated diseases, which would require special modification, as in the case of diabetes mellitus, hypertension, osteoporosis and constipation. Sometimes it is necessary to use artificial products to achieve different desired textures and precooked dishes, too. Source

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