Hospital Clinico San Cecilio

Granada, Spain

Hospital Clinico San Cecilio

Granada, Spain
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Ros Die E.,University of Granada | Ros Vidal R.,Hospital Clinico San Cecilio
Angiologia | Year: 2017

The appearance of minimally invasive surgery, and within it, the endovascular techniques, in relation to the sociocultural evolution of the doctor-patient relationship from the era of the so-called medical paternalism that, once the human rights and the rights of the patients came on the scene, patients gained freedom as regards their health, diagnosis and therapeutic techniques they receive. Finally, the history of endovascular techniques is briefly described, and the name Endovascular Surgery is formally proposed to include these. Finally, some thoughts are expressed on the current technolatry and the technological developments they entail. © 2017 SEACV.

Unciti-Broceta J.D.,Hospital Clinico San Cecilio | Unciti-Broceta J.D.,Institute Parasitologia y Biomedicina Lopez Neyra IPBLN CSIC | Del Castillo T.,Hospital Clinico San Cecilio | Del Castillo T.,Institute Parasitologia y Biomedicina Lopez Neyra IPBLN CSIC | And 6 more authors.
Therapeutic Delivery | Year: 2013

Nanobodies (Nbs) are small antibody fragments derived from camelid heavy chain antibodies through recombinant gene technology. Their exceptional physicochemical properties, possibility of humanization and unique antigen recognition properties make them excellent candidates for targeted delivery of biologically active components. Several different therapeutic approaches based on the novel camelid Nbs have been developed to treat a wide range of diseases ranging from immune, bone, blood and neurological disorders; infectious diseases and cancer. This review provides a comprehensive overview of the current state of the use of camelid-derived Nbs as novel therapeutic agents against multiple diseases. © 2013 Future Science Ltd.

Molina-Carballo A.,University of Granada | Molina-Carballo A.,Hospital Clinico San Cecilio | Checa-Ros A.,Hospital Clinico San Cecilio | Munoz-Hoyos A.,University of Granada | Munoz-Hoyos A.,Hospital Clinico San Cecilio
Expert Opinion on Therapeutic Patents | Year: 2016

Introduction. Attention deficit and hyperactivity disorder (ADHD) is a syndrome that affects children prior to 12 years of age. ADHD manifests as inappropriate behavior and learning difficulties and, in many cases, it persists into adulthood. In most cases, pharmacological treatment is sufficient; however, this approach frequently does not address all symptomatology of comorbidities and also affects the risk of secondary side effects that may influence compliance. Areas covered. This review emphasizes the recent progress in ADHD treatment, which was published in the patent literature from 2005-2015. We focused on novel mechanisms of action and potential treatments for achieving control of ADHD comorbidities, offering theoretical advantages compared with current medication. Newer agents are also proposed in recent patents and compounds for child and adult ADHD. Expert opinion. The patented drugs and compositions may provide a greater opportunity to develop more personalized, effective, and tolerable medications, without the liability of abuse. Particularly interesting will be the results obtained with drugs with a dual mechanism of action, agonists of trace amine receptors, and compounds that exhibit cognitive enhancing properties. Effectiveness and efficacy studies are also necessary to determine whether the characteristics of different drugs are related to their effects on disease. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Carvajal Pedrosa C.,Hospital Clinico San Cecilio | Hernandez Cortes P.,Hospital Clinico San Cecilio
Revista Espanola de Cirugia Ortopedica y Traumatologia | Year: 2011

Objective: To evaluate the results obtained in the treatment of intertrochanteric hip fractures with a percutaneous compression plate (PCCP). Material and method: We analysed 611 patients, operated on using PCCP, with a mean age of 79 years (65 to 99 years). The minimum follow up was 10 months (10 to 24). Data associated with blood loss and the post-operative recovery of the patients were analysed. Results: The mean duration of surgery was 32. minutes (15 to 75. min). The mean drop in the haemoglobin value was 1.9. g/dl (0.3 to 8.4). A blood transfusion was required by 14.7% of patients, with a mean of 0.25 transfusion units (0 to 3). The mean hospital stay was 8 days. There were 12.6% medical complications and 5% radiological complications. The overall mortality in the first year was 3.8% (23 patients). Conclusions: An early functional recovery of the patient associated with a low morbidity was achieved with PCCP, making it an alternative for the treatment of intertrochanteric hip fractures. © 2010 SECOT.

Uberos J.,Hospital Clinico San Cecilio | Miras-Baldo M.,Hospital Clinico San Cecilio | Jerez-Calero A.,Hospital Clinico San Cecilio | Narbona-Lopez E.,Hospital Clinico San Cecilio
Pediatrics and Neonatology | Year: 2014

Background: To assess the effectiveness of vitamin A supplementation in very low birth weight (VLBW) infants to prevent complications of prematurity.Methods: This was a retrospective cohort study to determine the effectiveness of vitamin A in preventing complications of prematurity in VLBW infants. Vitamin A was delivered intramuscularly at a dose of 5000 IU, three times weekly during the first 28 days of life.Results: Of the 187 eligible VLBW infants, we excluded from the analysis (due to death or transfer to another hospital), 16 infants weighing <1000 g and 17 weighing 1000e1500 g. Sixty VLBW infants received the vitamin supplement. We observed no differences between the groups in the duration of oxygen therapy or in the risk of bronchopulmonary dysplasia. The risk of sepsis was up to three times higher among the infants who were given the vitamin A supplement.Conclusion: Given the increased risk of sepsis in patients weighing >1000 g, the risk associated with repeated intramuscular injections of vitamin A and the modest clinical results described, we do not believe the universal administration of vitamin A to VLBW infants to be justified as prophylaxis for bronchopulmonary dysplasia. © 2014, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.

Gonzalez-Moles M.,University of Granada | Scully C.,Eastman Dental Institute | Ruiz-Avila I.,Hospital Clinico San Cecilio
Oral Diseases | Year: 2012

The development of multiple oral tumours, seen in up to 30% of patients with a primary oral squamous cell carcinoma, is sometimes attributable to the presence of genetically altered premalignant fields and has important prognostic implications. Molecular techniques available for the definitive diagnosis of such a field (loss of heterozygosity analysis of 3p, 9p and 17p and study of TP53 tumour suppressor gene mutation) are expensive, complex and not universally available, hampering their routine application. Nevertheless, molecular diagnosis is essential for modern assessment of the risk of multiple tumours and for decisions on the appropriate preventive and therapeutic approaches. This article reviews current knowledge on molecular findings in premalignant fields in the oral cavity and oropharynx and provides an update on criteria for their identification, discussing the clinical and therapeutic implications. © 2011 John Wiley & Sons A/S.

Uberos J.,Hospital Clinico San Cecilio | Molina-Carballo A.,Hospital Clinico San Cecilio | Fernandez-Puentes V.,Hospital Clinico San Cecilio | Rodriguez-Belmonte R.,Hospital Clinico San Cecilio | Munoz-Hoyos A.,Hospital Clinico San Cecilio
European Journal of Clinical Microbiology and Infectious Diseases | Year: 2010

We analysed the asymptomatic carrier state of Neisseria meningitidis in a sample of 339 children. We obtained data for the children's weight and height, in order to calculate the body mass index (BMI). The cutoff points defined by Cole were employed in determining the BMI, and the population was divided into three groups: normal, overweight and obese. Twenty carriers of N. meningitidis were identified. There was found to be a statistically significant trend to increased risk of being a carrier with increased BMI (z=2.03; P=0.04); after adjusting for age using the Mantel-Haenszel weighting method, this relationship was strengthened (z=2.38; P=0.01). Paediatric patients with increased BMI in the range of obesity present a three times greater risk of being carriers of N. meningitidis than non-obese patients, with a trend for this risk to increase with higher BMI © Springer-Verlag 2009.

Rodriguez del Aguila M.M.,Hospital Virgen Of Las Nieves | Gonzalez-Ramirez A.R.,Hospital Clinico San Cecilio
Allergologia et Immunopathologia | Year: 2014

When designing any research project, definition is required of the sample size needed in order to carry out the study. This sample size is an estimate of the number of patients required in accordance with the pursued study objective. In this context, it is more efficient in terms of both cost and time to use samples than to work with the entire population.The present article describes the way to establish sample size in the kinds of studies most frequently found in health research, and how to calculate it using the epicalc package included in the shareware R program. A description is provided of the formulae used to calculate sample sizes for the estimation of a mean and percentage (referring to both finite and infinite populations) and for the comparison of two proportions and two means. Likewise, examples of the application of the mentioned statistical package are provided. © 2013 SEICAP.

Uberos J.,Hospital Clinico San Cecilio | Augustin-Morales M.C.,Hospital Clinico San Cecilio | Molina Carballo A.,Hospital Clinico San Cecilio | Florido J.,Hospital Clinico San Cecilio | And 2 more authors.
Journal of Pineal Research | Year: 2011

This study evaluated the sleep-wake pattern, plasma melatonin levels and the urinary excretion of its metabolite, 6-sulphatoxy-melatonin among children with severe epileptic disorders, before and after a therapeutic trial with melatonin. Ten paediatric patients, suffering from severe epileptic disorders, were selected and given a nightly dose of 3 mg of a placebo, for 1 wk; for the next 3 months, the placebo was replaced with a nightly dose of 3 mg of melatonin. At the end of each treatment period, the urinary excretion of 6-sulphatoxy-melatonin (for the intervals 09.00 - 21:00 hr or 21:00-09:00 hr) and plasma levels of melatonin (recorded at 01:00, 05:00, 09:00, 13:00, 17:00 and 21:00 hr) were recorded, over a period of 24 hr; an actigraph record was also kept. Sleep efficiency among patients who received melatonin was significantly higher than among those given the placebo, with fewer night-time awakenings. Periodic plasma melatonin levels were regained and a better control gained of convulsive episodes, in that the number of seizures decreased. We conclude that melatonin is a good regulator of the sleep-wake cycle for paediatric patients suffering from severe epilepsy, moreover, it to a better control of convulsive episodes. © 2010 John Wiley & Sons A/S.

Poveda E.,Hospital Carlos III | Anta L.,Hospital Carlos III | Perez-Elias M.J.,Hospital Ramon y Cajal | Garcia F.,Hospital Clinico San Cecilio | And 5 more authors.
AIDS | Year: 2010

The prevalence of etravirine resistance mutations was examined in genotypes derived from 1343 HIV-infected patients failing nevirapine or efavirenz in the resistance database of the Spanish AIDS Research Network (ResRIS). Overall, etravirine-resistant genotypes were recognized in 18.7% of patients, with no significant differences between failures under nevirapine or efavirenz. Thus, more than 80% patients with prior failure to nonnucleoside reverse transcriptase inhibitors could potentially benefit from etravirine rescue therapy. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

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