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Barberan J.,Hospital Central de la Defensa Gomez Ulla | Aguilar L.,Complutense University of Madrid | Gimenez M.-J.,Complutense University of Madrid
International Journal of General Medicine | Year: 2012

This article reviews and updates published data on cefditoren. The in vitro activity of cefditoren and its potential pharmacokinetic/pharmacodynamic adequacy to cover emerging resistance phenotypes in the present decade is reviewed. Cefditoren's in vitro activity against most prevalent bacterial respiratory pathogens in the community and its pharmacokinetic/ pharmacodynamic profile suggests a significant role for cefditoren in the treatment of respiratory tract infections. Clinical trials (in acute exacerbations of chronic bronchitis, communityacquired pneumonia, pharyngotonsillitis, and sinusitis) performed during clinical development outside Japan, mainly in adults, are reviewed, together with new clinical studies in the treatment of pharyngotonsillitis, sinusitis, and otitis media in children, mainly in Japan, for efficacy and safety assessment. The results of these studies support the adequacy of cefditoren for the treatment of community-acquired respiratory tract infections with a safety profile similar to previous oral antibiotics. From the data reviewed, it is concluded that cefditoren is an adequate option for the treatment of mild-to-moderate community-acquired respiratory infections, especially in geographical areas with a reported prevalence of phenotypes exhibiting nonsusceptibility to common oral antibiotics. © 2012 Barberán et al, publisher and licensee Dove Medical Press Ltd.


Benavente C.,Hospital Clinico San Carlos | Seri C.,Hospital Central de la Defensa Gomez Ulla | Inigo B.,Hospital Clinico San Carlos | Martinez R.,Hospital Clinico San Carlos
Reviews in Clinical Gerontology | Year: 2015

Neoplasms of the lymphoid tissues represent a large, heterogeneous group of diseases that vary in clinical severity and response to treatment. The incidence of lymphoma in older patients is growing, yet guidelines on specifically how these patients should be treated are lacking. Moreover, older people are excluded from most of the clinical trials and management decisions are usually based on data obtained in younger patients. This review might consider the optimal strategy for lymphoma diagnosis and treatment in older patients. Copyright © Cambridge University Press 2015.


Pedraza A.M.,Hospital Central de la Defensa Gomez Ulla | Pedraza A.M.,Institute Salud Carlos III | Pollan M.,Institute Salud Carlos III | Pollan M.,Consortium for Biomedical Research in Epidemiology and Public Health | And 3 more authors.
Breast Cancer Research and Treatment | Year: 2012

In recent decades, breast cancer cases have increased steadily worldwide. However, the increases do not hold across all demographics and breast cancer cases in low and middle income countries have increased much faster than the global trend. Colombia is not an exception. Breast cancer was the most frequent tumor and the second cause of cancer-related deaths in women in 2008, with an estimated of 6,700 new cases and 2,100 deaths. We present here an analysis of breast cancer mortality rates and trends in Colombia, over the period 1985-2008. We studied overall and age-specific changes in breast cancer mortality using change-point Poisson regression models. Between 1985 and 2008, there were 32,375 breast cancer deaths in women in Colombia. Breast cancer mortality increased since 1985, although the annual increase varied between age groups and socioeconomic levels. Only in women aged 45-64 years old that live in areas of high socioeconomic levels, breast cancer mortality was stable or decreasing. Hence, successful cancer control is possible in middle income countries, as shown by the progress observed in certain groups. The development of an integrated strategy of early detection and early access to proper treatment, suitable for areas with limited resources, is an urgent necessity. © Springer Science+Business Media, LLC. 2012.


Martin M.J.,Hospital Central de la Defensa Gomez Ulla | Zapatero J.,Hospital Central de la Defensa Gomez Ulla | Lopez M.,Hospital Universitario Of La Princesa
Reports of Practical Oncology and Radiotherapy | Year: 2011

All radiation devices in use nowadays are subject to cause serious incidents and accidents, with potential risks in exposed population groups. These risks may have immediate or long term health implications. The detection of radioactive incidents is a procedure that should be systematized in economically developed societies. International organizations may provide support to other states in the event of a radioactive incident. Prevention, mitigation and treatment of the radiation effects are done by anticipating the moment of exposure and by establishing new efforts for investigation of radioprotective products.In this article we will analyze the causes of radiological incidents, the means to detect them, and the current preventive and therapeutic procedures available, with special emphasis on new biodosimetry methods for triage and investigational radioprotective drugs. Finally, we will explore the most efficient measures, for future prevention. © 2011.


Crego-Vita D.,Hospital Central de la Defensa Gomez Ulla | Aedo-Martin D.,Hospital Central de la Defensa Gomez Ulla | Sanchez-Perez C.,Hospital General Universitario Gregorio Maranon
International Journal of Surgery Case Reports | Year: 2016

Paget's disease of bone is a localised chronic osteopathy which produces bone deformities, bone hypervascularity, structural weakness and altered joint biomechanics. Although radiological diagnosis of Paget's disease of bone is usually straightforward, monostotic cases may potentially raise specific problems which require invasive and expensive procedures such as bone biopsies. The pelvis and upper femur are frequently affected, resulting in disabling hip disease that may require total hip arthroplasty. We report a case of Paget disease of bone in an 84-year-old woman, which was initially identified as avascular necrosis of the hip, reason for which she underwent total hip arthroplasty. During follow up, the patient complained about hip pain and in a few months she was not able to walk because of an early loosening with bone destruction. Radiological and laboratory exams were carried out with normal results except for alkaline phosphatase (AP). After treatment with biphosphonates hip pain relieved but hip reconstruction was not possible. In this paper we present an early aseptic loosening of hip arthroplasty due to monostotic Paget's disease of bone, a rare ethiology of loosening which poses particular diagnostic difficulties prompting an excessive use of excisional biopsies. © 2016 The Authors. Published by Elsevier Ltd.

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