Carbonell Esteve J.L.,Mediterranea Medica Clinic |
Riveron A.M.,Eusebio Hernandez Obstetrics Teaching Hospital |
Cano M.,Eusebio Hernandez Obstetrics Teaching Hospital |
Ortiz A.I.,Aleman Hospital |
And 3 more authors.
International Journal of Women's Health
Objectives: To evaluate the efficacy and safety of 2.5 mg and 5 mg mifepristone during 3 months for the treatment of uterine fibroids before surgery. Design: Multicenter randomized clinical trial. Locations: Eusebio Hernández Hospital, Havana, Cuba and the Alemán Hospital, Managua, Nicaragua. Subjects: Included in the study were 146 women with symptomatic uterine fibroids. Treatment: Group I: half a tablet of 5 mg (2.5 mg) mifepristone taken orally every 24 hours, and Group II: one tablet of 5 mg mifepristone taken orally every 24 hours over a period of 3 months in both groups. Two endometrial biopsies were performed. Variables to evaluate efficacy: Increase in average hemoglobin, changes in fibroid and uterine volume, and symptomatic improvement. Results: The average hemoglobin at the end of treatment was 0.6 g/dL greater in the 5 mg mifepristone group (P = 0.033). In both groups there were similar reductions in fibroid volumes. Clinical improvement was more significant in the 5 mg group. Conclusion: The dose to be used should be 5 mg. © 2012 Carbonell Esteve et al, publisher and licensee Dove Medical Press Ltd. Source
Larralde M.,Ramos Mejia Hospital |
Moya A.I.S.,Complejo Hospitalario Toledo |
Abad M.E.,Ramos Mejia Hospital |
Luna P.C.,Ramos Mejia Hospital |
And 2 more authors.
Dermatology Online Journal
A ten-month-old girl presented to our clinic with a progressively enlarging congenital mass at the midline suprasternal location. Histopathologic examination revealed a benign cyst with stratified squamous keratinized epithelium with numerous eccrine glands in the sinus wall. The diagnosis was compatible with dermoid cyst. Dermoid cysts of the trunk are rare lesions, but a midline location is characteristic for these congenital masses. A dermoid cyst should be high on the list of differential diagnoses given a unilocular midline cyst in a neonate. © 2010 Dermatology Online Journal. Source