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Runcorn, United Kingdom

Bryan S.,Hosokawa Micron Ltd.
Polymers Paint Colour Journal | Year: 2010

Hosokawa Micron has developed and extended its range of laboratory equipment suitable for the polymer and paint sector. Small-scale laboratory processing equipment which meets demands for product development on a miniature scale is discussed. Demands for increasingly ultra-fine powders and nano powders, materials with combinations of specific performance characteristics and high value materials continue to escalate, contributing to the emergence of new laboratory and production equipment, often utilizing existing technology transferred from other industries. Hosokawa Micron is well known worldwide for the supply of a wide range of powder processing equipment and processes with brand names such as Alpine, Mikro, Vrieco, Nauta and many others but these full scale industrial units have their counterparts in the laboratory/research scale fields. Hosokawa Micron is one of the world's leading companies specializing in powder and solids processing having many industry standard brand names within its portfolio. Source


Chen L.,Kyushu University | Nakano K.,Kyushu University | Kimura S.,Kyushu University | Matoba T.,Kyushu University | And 7 more authors.
Hypertension | Year: 2011

Pulmonary artery hypertension (PAH) is an intractable disease of the small PAs in which multiple pathogenic factors are involved. Statins are known to mitigate endothelial injury and inhibit vascular remodeling and inflammation, all of which play crucial roles in the pathogenesis of PAH. We tested the hypothesis that nanoparticle (NP)-mediated delivery of pitavastatin into the lungs can be a novel therapeutic approach for the treatment of PAH. Among the marketed statins, pitavastatin was found to have the most potent effects on proliferation of PA smooth muscle cells in vitro. We formulated pitavastatin-NP and found that pitavastatin-NP was more effective than pitavastatin alone in inhibiting cellular proliferation and inflammation in vitro. In a rat model of monocrotaline-induced PAH, a single intratracheal instillation of NP resulted in the delivery of NP into alveolar macrophages and small PAs for up to 14 days after instillation. Intratracheal treatment with pitavastatin-NP, but not with pitavastatin, attenuated the development of PAH and was associated with a reduction of inflammation and PA remodeling. NP-mediated pitavastatin delivery was more effective than systemic administration of pitavastatin in attenuating the development of PAH. Importantly, treatment with pitavastatin-NP 3 weeks after monocrotaline injection induced regression of PAH and improved survival rate. This mode of NP-mediated pitavastatin delivery into the lungs is effective in attenuating the development of PAH and inducing regression of established PAH, suggesting potential clinical significance for developing a new treatment for PAH. © 2011 American Heart Association. All rights reserved. Source


Nogi K.,Hosokawa Micron Ltd.
Scripta Materialia | Year: 2010

The effects of oxygen, applied DC voltage and surface orientation on the wettability of ceramics by liquid metals are clarified and new methods for metal-ceramic joining are proposed based on information from wetting experiments, using three examples. The strengths of Ni-Al2O3 joints obtained at very low oxygen potentials are higher than in high oxygen potential environments. Applying a DC voltage to the interface between metals and partially stabilized zirconia is shown to improve the strength of metal-zirconia joints. Cu and SiC can be strongly joined without using active elements such as Ti and Zr by controlling the joining conditions. © 2010 Acta Materialia Inc. Source


Inoue Y.,Hosokawa Micron Ltd.
Nippon Shokuhin Kagaku Kogaku Kaishi | Year: 2011

Powder technology is widely utilized for food applications. In particular, fine milling has become an important unit operation in recent years. The air classification mill, pin mill and fluidized-bed opposed jet mill were tested in the preparation of ground soybeans. The air classification mill could not continuously operate due to overload, resulting from the blockage of ground material. Thermal analysis of soybeans revealed the difficulty in preventing this phenomenon. The pin mill was able to grind soybeans down to 10-30μm at a throughput of 12kg/h. A finely ground product with a particle size of 10μm was obtained only by repeated milling, meaning that the product ground by pin milling was processed again using the same machine. A fluidized-bed opposed jet mill could grind the soybeans by processing the pin mill product down to 5μm at 20kg/h. The combination of mill and air classifier was able to increase the protein ratio in the starch-rich seeds. The mill not only produced fine particles but also separated the protein from starch granules in the system. The air classifier acts to separate the released protein from the starch granules by exploiting their size differences. Source


Bryan S.,Hosokawa Micron Ltd.
PPCJ Polymers Paint Colour Journal | Year: 2012

Research and Development and Quality Control are key drivers in any business with the laboratory being a critical hub in the wheel of success. This is true not only in the coatings industry but in all those where demands for improved materials and materials with varied characteristics are incessant and where it is crucial to maintain that competitive edge. The leader in particle size analysis and reputed industry standard device, the Alpine Air Jet Sieve has recently been upgraded and is now faster, easier to use and more accurate than ever before. The e200 LS version is now complete with a range of innovative accessories to complement the three software packages available: eControl Basic, Professional and Ultimate, which cover the entire range of particle size analysis to meet the high specifications and expectations of materials engineers, process engineers and quality control engineers. Source

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