San Jose, CA, United States
San Jose, CA, United States

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Patent
Horizon Inc. | Date: 2017-02-22

The invention provides a method for determining a dose and schedule and making dose adjustments of PBA prodrugs used to treat nitrogen retention states, or ammonia accumulation disorders, by measuring urinary excretion of phenylacetylglutamine and/or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patients dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered ammonia scavenging drug.


Patent
Horizon Inc. | Date: 2016-01-20

It is an object of the present invention to provide a saddle-stitch and fold machine which can manufacture a booklet which does not have the toner crack and the swell along a fold line. The creaser 2 includes a project part 21 for forming the crease 120 on the sheet 101 and a receive part 22 for receiving the project part 21. The project part 21 is moved between a crease position and a standby potion, the project part 21 being at the crease position so as to form the crease 120 on the sheet 101, the project part 21 being away from the sheet 101 at the standby position so as not to form the crease 120 on the sheet 101. The input device 6 includes a selector 60 for selecting the sheet 101 to be creased by the creaser 2 from among the sheets 101 fed from the conveyer 1, the input device 6 sending the information of the selection to the controller 5.


The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.


The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.


The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.


The present disclosure provides methods for treating hepatic encephalopathy (HE) and for optimizing and adjusting nitrogen scavenging drug dosage for subjects with HE.


Patent
Horizon Inc. | Date: 2016-03-07

A phase separator and associated method for removal of water from a sample containing analytes in an organic solvent including a vertically extending body portion for vertical extension into a receptacle, the body portion including at least one vertically extending membrane portion on at least one side thereof and a port for introduction of solvent.


The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: ITEST | Award Amount: 655.00K | Year: 2015

The project will develop and research the impact of an expanded model for mathematics professional development (PD) for elementary second and third grade teachers. It builds on the NSF-funded project, All Included in Mathematics (AIM). The PD is designed for elementary teachers to learn and use successful mathematics discussion strategies shown to support student learning. This project will expand the framework by improving teacher access to resources with web-based tools, targeting a new target audience of teachers in PD, and researching the impact of Project AIM via analysis of student data. The project partnership between university faculty and mathematics curriculum leaders from school districts will develop the web-based professional development resources. The project is co-funded by three programs: ITEST, EHR Core Research and Cyberlearning. The EHR Core Research program emphasizes fundamental STEM education research that generates foundational knowledge in the field. Investments are made in critical areas that are essential, broad and enduring: STEM learning and STEM learning environments, broadening participation in STEM, and STEM workforce development. This project will also advance efforts of the Innovative Technology Experiences for Students and Teachers (ITEST) program to better understand and promote practices that increase students motivations and capacities to pursue careers in fields of science, technology, engineering, or mathematics (STEM). The Cyberlearning and Future Learning Technologies Program funds efforts that will help envision the next generation of learning technologies and advance what we know about how people learn in technology-rich environments.

The overarching goal of the project is to conduct an efficacy study to understand how a professional development program, targeting elementary math teachers, can be used with web-based facilitator support and less support from the original research and development team. The research questions ask about the extent to which teachers who did not work with the prior project can implement the new Project AIM materials with fidelity. The research will also investigate the impact of the professional development on teachers knowledge, beliefs and mathematics teaching. Finally, the study is also examining the impact on students participation in mathematics discussions and content learning with particular attention to English Language Learner students. The study is an experimental design in which school teams are randomly assigned to the initial treatment or delayed treatment conditions. Data will be collected to understand the efficacy of the intervention and will include facilitator implementation logs, measures of teacher knowledge, classroom artifacts, classroom observations, student discourse observation and student achievement data.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: PROGRAM EVALUATION | Award Amount: 3.00M | Year: 2016

Exemplary teaching in STEM fields encourages students from diverse backgrounds to pursue further education and careers in science, technology, engineering and mathematics. Improving teaching, however, first requires an understanding of the current landscape of STEM instruction. The 2018 National Survey of Science and Mathematics Education (NSSME+) will explore the extent to which such instruction currently models effective, evidence-based, teaching practices, and also will investigate the factors that influence teachers? decisions about content and pedagogy. This will mark the sixth in a series of the national surveys monitoring the status of science and mathematics education conducted by Horizon Research Inc. with assistance from Westat. This iteration will add a focus on computer science and engineering education. The 2018 data will attend to factors that contribute to the underrepresentation of some groups in STEM, further adding to general knowledge about ways to broaden participation. The project is funded by the EHR Core Research program, which supports fundamental research that advances the research literature on STEM learning, and has implications for education in both formal and informal settings.

The 2018 NSSME study will yield accurate, up-to-date measures of key elements of the STEM education system, and identify trends in these areas over time. The study will collect data on teacher characteristics, including teacher content background and demographics; course offerings and enrollments; textbook/program usage; instructional strategies; formative assessment; and the influences of particular policies (e.g., the Every Student Succeeds Act). In addition to national estimates, the study will provide results disaggregated by type of community and characteristics of the student body. The investigators will invite the Principal Investigators of the NSF Indicator projects to offer input on the 2018 NSSME+ instruments, with an eye towards identifying how the work of their projects could be infused or adapted into a large-scale survey. All analyses will be conducted using weighted data, with school, teacher, and class weights calculated to reflect the sample design selection probabilities.

The Promoting Research and Innovation in Methodologies for Evaluation (PRIME) program seeks to support research on evaluation with special emphasis on: (1) exploring innovative approaches for determining the impacts and usefulness of STEM education projects and programs; (2) building on and expanding the theoretical foundations for evaluating STEM education and workforce development initiatives, including translating and adapting approaches from other fields; and (3) growing the capacity and infrastructure of the evaluation field. Three types of proposals will be supported by the program: Exploratory Projects that include proof-of-concept and feasibility studies; more extensive Full-Scale Projects; and workshops and conferences. This proposal meets the requirements of category 1 above.

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