HORIBA ABX SAS

Murviel-lès-Montpellier, France

HORIBA ABX SAS

Murviel-lès-Montpellier, France

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Patent
Horiba ABX SAS | Date: 2017-01-04

The invention relates to a sampling valve and to a device equipped with such a valve notably allowing haematology measurements to be taken from a blood sample. The valve comprises two external parts, one internal part clamped between said external parts, and means for regulating the relative angular position of these parts about an axis of rotation. The internal part has opposite surfaces pressing in a sealed and sliding manner against adjacent surfaces of the external parts. The external parts comprise orifices, loops and ducts, said loops and said ducts being arranged in such a way as to communicate selectively with orifices passing through the internal part. The valve parts have no aliquot return groove or recess or labyrinth, thereby eliminating regions of turbulence. The valve is characterized in that two of the parts are able to rotate about the axis of rotation with respect to one of the said parts which is stationary, the rotary parts preferably being the external parts. The sampling valve also makes it possible to form calibrated volumes of a sample taken in the loops and/or the orifices of the internal part.


Scope of the Report: Report mainly focus on Hematology Analyzer in Worldwide market, especially report covers Hematology Analyzer market like, in North America, Hematology Analyzer market in Europe, Hematology Analyzer market in Asia-Pacific, Hematology Analyzer market in Latin America, Middle as well as Africa. This report categorizes the Hematology Analyzer market based on manufacturers, regions, type and Hematology Analyzer market application. Market Segment by Manufacturers, this report covers 1. Sysmex Corporation 2. Beckman Coulter, Inc. 3. Abbott Laboratories 4. Siemens Healthcare 5. Bayer 6. HORIBA ABX SAS 7. A.S.L 8. Boule Diagnostics AB 9. Research and Production Complex Biopromin Ltd 10. Mindray 11. Sinnowa 12. Hui Zhikang 13. Jinan Hanfang 14. Gelite 15. Sinothinker 16. Bio-Rad Laboratories 17. Nihon Kohden 18. Abaxis Market Segment by Applications, can be divided into 1. Hospital 2. Laboratory Market Segment by Regions, regional analysis covers 1. Hematology Analyzer Market in North America (USA, Canada and Mexico). 2. Europe Hematology Analyzer Market(Germany, France, UK, Russia and Italy). 3. Hematology Analyzer Market in Asia-Pacific (China, Japan, Korea, India and Southeast Asia). 4. Latin America Hematology Analyzer Market, Middle and Africa. Global Hematology Analyzer market report covers Manufacturers Profiles with their Business Overview which also includes Hematology Analyzer Type and Applications, Hematology Analyzer Sales, Price, Revenue and Hematology Analyzer Market Share. This report also includes Global Hematology Analyzer Market Competition, by Manufacturer, Hematology Analyzer Sales and Market Share by Manufacturer. Global Hematology Analyzer Sales as well as Hematology Analyzer Revenue by Regions (2011-2016) Report on (Worldwide Hematology Analyzer Market) mainly covers 10 Chapters to deeply display the global Hematology Analyzer market. Chapter 1, to analyze the Hematology Analyzer market’s top manufacturers, with sales, Hematology Analyzer market revenue, and price of Hematology Analyzer , in 2015 and 2016; Chapter 2, to display the Hematology Analyzer market’s competitive situation among the top manufacturers, with Hematology Analyzer market sales, revenue and Hematology Analyzer market share in 2015 and 2016; Chapter 3, to show the global Hematology Analyzer market by regions, with sales, Hematology Analyzer revenue and market share of Hematology Analyzer , for each region, from 2011 to 2016; Chapter 4, 5, 6 and 7, to analyze the key regions, with Hematology Analyzer market sales, revenue and share by key countries in these regions Hematology Analyzer Market scenario; Chapter 8 and 9, to show the Hematology Analyzer market by type and application, with sales Hematology Analyzer market share and growth rate by type, Hematology Analyzer market application, from 2011 to 2016. Chapter 10, Global Hematology Analyzer market forecast, by regions, type and application, with Hematology Analyzer market sales and revenue, from 2016 to 2021.


Cauet G.,HORIBA ABX SAS | Daynes A.,HORIBA ABX SAS | Temurok N.,HORIBA ABX SAS
Practical Laboratory Medicine | Year: 2016

Objective: The technology of magnetic field-assisted immuno-agglutination of superparamagnetic particles allows sensitive detection of biomarkers in whole blood. However, we observed non-specific agglutination (NSA), due to interfering plasma proteins, that negatively affects C-reactive protein immunoassay. The objective of the study was to identify the plasma proteins involved and to eliminate these interferences. Design and methods: Plasma was fractionated by size exclusion HPLC and each fraction was tested for non-specific agglutination. In addition, plasma proteins bound to magnetic particles were analyzed by SDS-gel electrophoresis and identified by mass spectrometry. Results: We found that NSA was due to the binding of some lipoproteins to the particles. NSA was observed in the presence of purified LDL and VLDL but not HDL. NSA was mediated by the binding of ApoB100 to magnetic particles through its heparin binding sites. These interferences could be eliminated by addition of heparin or other polyanions like dextran sulfate to the assay buffer. Conclusion: NSA results from the binding of some plasma lipoproteins to magnetic particles. The use of a polyanion to eliminate these interferences allows the formulation of a stable reagent. © 2016 The Authors.


The invention relates to an electro-optical device for measurements of flow for the characterization of microparticles, comprising a measurement chamber (CUM) in which there circulates the flow of the fluid to be characterized, at least two luminous sources (S1,S2) of disjoint spectra, a device for measuring resistivity (RES), and at least three other detectors (D1,D2,D3) each allowing the measurement of an optical parameter, the optical parameters being chosen from among fluorescence (FL), extinction (EXT), wide angle diffraction (SSC) and small angle diffraction (FSC).


Patent
Horiba Abx Sas | Date: 2015-02-20

The invention relates to a sampling valve and to a device equipped with such a valve notably allowing haematogy Ineasttrenreaat to be taken from a blood sample. The valve comprise two external parts, one internal part clamped between said exterrtal parts, and means for regulating the relative angular position of these parts about to axis of rotation. The mienial part has opposite surfaces pressing in a sealed and sliding manner against adjacent surfaces of the external parts. The external parts comprise orifices, loops and ducts, said loops and said ducts being arranged in such a way as to communicate selectively with orifices passing through the internal part. The valve parts have no aliquot return groove or recess or labyrinth, thereby eliminating regions of turbulence. The valve is characterized in that two of the parts are able to rotate about the axis of rotation with respect to one of the said pans which is stationary, the rotary parts preferably being the external parts. The sampling valve also makes it possible to form calibrated volumes of a sample taken in the loops and/or the orifices of the internal pan.


The present invention concerns a device for analyzing biological parameters from a sample (6) comprising (i) first transferring means (5, 20, 25), (ii) first preparing means (7), (iii) means for measuring cellular components (8), (iv) second preparing means (10, 11, 22, 23, 24) capable of carrying out, on a sample from the first preparing means (7), at least one dilution with an assay reagent (R3) comprising particles functionalized at the surface with at least one ligand specific to at least one analyte of interest, (v) immunodetection measurement means (30, 31) capable of assaying at least one analyte of interest by measuring the aggregation of functionalized particles, said device further comprising (i) second transferring means (4, 21, 22, 26) at least partially separate from the first transferring means (5, 20, 25) and (ii) means for applying a magnetic field (28) capable of causing, by magnetic interaction, an acceleration of the aggregation of said functionalized particles, which comprise magnetic colloidal particles. The invention also concerns a method implemented in said device.


The present invention relates to a method for compensating for the breakdown of a reagent stored in an aqueous phase comprising at least one fluorescent compound and enabling the identification of particles, including the steps of: (i) measuring the fluorescence level FLUOm(t) of particles marked with said reagent; (ii) measuring the absorbance at at least one wavelength of a solution of said reagent, at a time t close to the time of said fluorescence level FLUOm(t) measurements, so as to determine at least one current optical density DO(t) of the reagent; and (iii) calculating a correction of the fluorescent level measurements using said at least one current optical density DO(t) and at least one initial optical density DO(0) of the reagent that has not been broken down. The invention also relates to a biological analysis device implementing the method.


The present application relates to: (i) a sampler device for taking a sample of biological fluid, which comprises a capillary component, and a base rigidly connected to said capillary component and provided with a first connector capable of being reversibly attached in a leaktight manner to a second connector of a dispensing device; (ii) a dispensing device which also comprises means for transferring diluting fluid which open into said second connector. The application also relates to a biological analysis apparatus implementing the sampler and dispensing devices and to a method for sampling and dispensing a biological fluid.


Patent
Horiba Abx Sas | Date: 2014-03-11

The present invention relates to a flow assay method in a liquid medium for an object (or element) of interest via the formation of aggregates of particles that are surface-functionalized by at least one functionalizing molecule, or receptor, specific for said object of interest.


Patent
Horiba Abx Sas | Date: 2013-03-14

The subject of the invention is a device for positioning an object in space, comprising at least 4 plates, each one able to move with respect to another of said plates which is contiguous with it along one of the 3 axes of space, it being possible for the movement of one plate with respect to another plate to be guided by a tenon/mortise assembly in which said tenon is secured to one of the plates and its mortise is produced in the other plate, the spatial orientation of each of the tenon/mortise assemblies being different from the other 2 and along one of the 3 axes of space.

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