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Hino M.,Industrial Technology Center Of Okayama Prefecture | Murakami K.,Industrial Technology Center Of Okayama Prefecture | Saijo A.,Hori Metal Finishing Industry | Hikino S.,Okayama University of Science | And 2 more authors.
Materials Transactions | Year: 2011

This study examined the possibility of surface heat treatment by the plasma electrolysis from phosphate electrolytic solution on magnesium alloys. Effects of the anodic plasma electrolysis onto various AZ series magnesium alloys on the mechanical properties and microstructure were examined. The tensile test revealed that the anodic electrolytic treatment at final bias voltage from 250V to 400V influenced the tensile strength. The tensile strength of AZ61 and AZ91D substrate after anodic electrolytic treatment increased or decreased, and this change of tensile strength is attributable to the precipitation of intermetallic compound (β phase, Mg 17Al 12) as sparks occurred due to dielectric breakdown during anodic electrolysis. These results demonstrate the utility of this electrolytic treatment on AZ61 and AZ91D magnesium alloys. © 2011 The Japan Society for Heat Treatment. Source

Shen J.,Hiroshima City University | Fukui O.,Izumisano City Hospital | Hashimoto H.,Hori Metal Finishing Industry | Nakashima T.,University of Marketing and Distribution Sciences | And 3 more authors.
Health Economics Review | Year: 2012

In April 2008, the specialization in departments of obstetrics and gynecology was conducted in Sennan area of Osaka prefecture in Japan, which aims at solving the problems of regional provision of obstetrical service. Under this specialization, the departments of obstetrics and gynecology in two city hospitals were combined as one medical center, whilst one hospital is in charge of the department of gynecology and the other one operates the department of obstetrics. In this paper, we implement a cost-benefit analysis to evaluate the validity of this specialization. The benefit-cost ratio is estimated at 1.367 under a basic scenario, indicating that the specialization can generate a net benefit. In addition, with a consideration of different kinds of uncertainty in the future, a number of sensitivity analyses are conducted. The results of these sensitivity analyses suggest that the specialization is valid in the sense that all the estimated benefit-cost ratios are above 1.0 in any case. © 2012 Shen et al; licensee Springer. Source

Hino M.,Hiroshima Institute of Technology | Murakami K.,Industrial Technology Center Of Okayama Prefecture | Hori T.,Hori Metal Finishing Industry | Kanadani T.,Okayama University of Science
Materials Transactions | Year: 2014

The effects of two different pretreatments on the anticorrosive performance of AZX911 magnesium alloy containing 1.0 mass% calcium treated with an anodizing from phosphate and ammonium salt solution have been studied. The AZX911 magnesium alloy after anodizing had a lower anticorrosive performance. The lowering of this anticorrosive performance was attributed to the 0.1 mass% calcium in the anodized coating. The anticorrosive performance of the AZX911 magnesium alloy was improved by applying a fluoride salt solution in the pretreatment. This fluoride salt solution treatment made it possible to remove calcium close to the surface of the AZX911 magnesium alloy substrate, the calcium content in an anodized coating being decreased. The anticorrosive performance was improved by the anodizing from phosphate and ammonium salt solution with a sacrificial anticorrosive effect. ©2014 The Japan Institute of Metals and Materials. Source

Nishikawa K.,Osaka National Hospital | Fujitani K.,Osaka General Medical Center | Inagaki H.,Gifu Central Hospital | Akamaru Y.,Osaka Kose Nenkin Hospital | And 13 more authors.
European Journal of Cancer | Year: 2015

Aim The optimal second-line regimen for treating advanced gastric cancer (AGC) remains unclear. While irinotecan (CPT-11) plus cisplatin (CDDP) combination therapy and CPT-11 monotherapy have been explored in the second-line setting, the superiority of second-line platinum-based therapies for AGC patients initially treated with S-1 monotherapy has not yet been evaluated; therefore, we aimed to examine the survival benefit of CPT-11/CDDP combination over CPT-11 monotherapy. Methods AGC patients showing progression after S-1 monotherapy for advanced cancer or recurrence within 6 months after completion of S-1 adjuvant therapy were randomly allocated to CPT-11/CDDP (CPT-11, 60 mg/m2; CDDP, 30 mg/m2, q2w) or CPT-11 (150 mg/m2, q2w). Results Sixty-eight advanced and 95 recurrent cases were evaluated. The median overall survivals were 13.9 (95% confidence interval [CI]: 10.8-17.6) and 12.7 (95% CI: 10.3-17.2) months for CPT-11/CDDP and CPT-11, respectively (hazard ratio: 0.834; 95% CI: 0.596-1.167, P = 0.288). No significant differences were observed in the secondary end-points, including progression-free survival (4.6 [95% CI: 3.4-5.9] versus 4.1 [95% CI: 3.3-4.9] months) and response rate (16.9% [95% CI: 8.8-28.3] versus 15.4% [95% CI: 7.6-26.5]). The incidences of grade 3-4 anaemia (16% versus 4%) and elevated serum lactate dehydrogenase levels (5% versus 0%) were higher for CPT-11/CDDP than for CPT-11. Exploratory subgroup analysis revealed that CPT-11/CDDP was significantly more effective for intestinal-type AGC, compared with CPT-11 (overall survival: 15.8 versus 14.0 months; P = 0.019). Conclusion No survival benefit was observed upon adding CDDP to CPT-11 after S-1 monotherapy failure. © 2015 The Authors. Published by Elsevier Ltd. Source

Hino M.,Industrial Technology Center Of Okayama Prefecture | Murakami K.,Industrial Technology Center Of Okayama Prefecture | Saijo A.,Hori Metal Finishing Industry | Hikino S.,Okayama University of Science | Kanadani T.,Okayama University of Science
Keikinzoku/Journal of Japan Institute of Light Metals | Year: 2010

The effects of various surface treatments on the friction and wear properties of AZ91D magnesium alloy substrate against the SUJ2 steel ball were evaluated by using a horizontal reciprocating friction and wear test apparatus. The friction and wear properties greatly changed due to the type of surface treatment in spite of being under equal friction and wear testing conditions. Wear loss of AZ91D magnesium alloy anodized from the phosphate solution was greatly reduced in comparison with the other surface treatments such as Dow17, conversion coatings and also no surface treatment. The above results suggest that anodizing from the phosphate solution should improve the friction and wear properties of magnesium alloy used for sliding parts. Source

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