Emporia, KS, United States
Emporia, KS, United States

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Patent
Princeton University and Hopkins Inc. | Date: 2017-01-18

The present invention relates to granular composite density enhancement, and related methods and compositions. The applications where these properties are valuable include but are not limited to: 1) additive manufacturing (3D printing) involving metallic, ceramic, cermet, polymer, plastic, or other dry or solvent-suspended powders or gels, 2) concrete materials, 3) solid propellant materials, 4) cermet materials, 5) granular armors, 6) glass-metal and glass-plastic mixtures, and 7) ceramics comprising (or manufactured using) granular composites.


Sausen M.,Ludwig Center for Cancer Genetics and Therapeutics | Leary R.J.,Ludwig Center for Cancer Genetics and Therapeutics | Jones S.,Ludwig Center for Cancer Genetics and Therapeutics | Jones S.,Hopkins Inc. | And 15 more authors.
Nature Genetics | Year: 2013

Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common solid tumor in children. To determine the genetic basis for neuroblastoma, we performed whole-genome sequencing (6 cases), exome sequencing (16 cases), genome-wide rearrangement analyses (32 cases) and targeted analyses of specific genomic loci (40 cases) using massively parallel sequencing. On average, each tumor had 19 somatic alterations in coding genes (range of 3-70). Among genes not previously known to be involved in neuroblastoma, chromosomal deletions and sequence alterations of the chromatin-remodeling genes ARID1A and ARID1B were identified in 8 of 71 tumors (11%) and were associated with early treatment failure and decreased survival. Using tumor-specific structural alterations, we developed an approach to identify rearranged DNA fragments in sera, providing personalized biomarkers for minimal residual disease detection and monitoring. These results highlight the dysregulation of chromatin remodeling in pediatric tumorigenesis and provide new approaches for the management of patients with neuroblastoma. © 2013 Nature America, Inc. All rights reserved.


Sierro N.,Philip Morris Products SA | Van Oeveren J.,Keygene NV | Van Eijk M.J.T.,Keygene NV | Martin F.,Philip Morris Products SA | And 3 more authors.
Plant Journal | Year: 2013

Genomics-based breeding of economically important crops such as banana, coffee, cotton, potato, tobacco and wheat is often hampered by genome size, polyploidy and high repeat content. We adapted sequence-based whole-genome profiling (WGP™) technology to obtain insight into the polyploidy of the model plant Nicotiana tabacum (tobacco). N. tabacum is assumed to originate from a hybridization event between ancestors of Nicotiana sylvestris and Nicotiana tomentosiformis approximately 200 000 years ago. This resulted in tobacco having a haploid genome size of 4500 million base pairs, approximately four times larger than the related tomato (Solanum lycopersicum) and potato (Solanum tuberosum) genomes. In this study, a physical map containing 9750 contigs of bacterial artificial chromosomes (BACs) was constructed. The mean contig size was 462 kbp, and the calculated genome coverage equaled the estimated tobacco genome size. We used a method for determination of the ancestral origin of the genome by annotation of WGP sequence tags. This assignment agreed with the ancestral annotation available from the tobacco genetic map, and may be used to investigate the evolution of homoeologous genome segments after polyploidization. The map generated is an essential scaffold for the tobacco genome. We propose the combination of WGP physical mapping technology and tag profiling of ancestral lines as a generally applicable method to elucidate the ancestral origin of genome segments of polyploid species. The physical mapping of genes and their origins will enable application of biotechnology to polyploid plants aimed at accelerating and increasing the precision of breeding for abiotic and biotic stress resistance. © 2013 John Wiley & Sons Ltd.


Trademark
Hopkins Inc. | Date: 2016-05-04

Jackets; Jeans; Jerseys; Shirts for infants, babies, toddlers and children; Shorts; Sweat shirts; Sweatpants; T-Shirts; Tank tops.


Trademark
Hopkins Inc. | Date: 2016-09-05

Hummus; Hummus chick pea paste.


Trademark
Hopkins Inc. | Date: 2013-10-29

Printed matter, namely, paper signs, books, manuals, curriculum, newsletters, informational cards and brochures in the field of Bible class.


Trademark
Hopkins Inc. | Date: 2016-02-02

Hooded sweatshirts; jackets; jeans; jerseys; shirts for infants, babies, toddlers, children; shorts; sweatpants; sweatshirts; T-shirts; tank tops.


Trademark
Hopkins Inc. | Date: 2014-09-15

Hooded sweatshirts; jackets; jeans; jerseys; shirts for infants, babies, toddlers and children; shorts; sweatpants; sweatshirts; t-shirts; tank tops.


Trademark
Hopkins Inc. | Date: 2014-09-15

Hooded sweatshirts; jackets; jeans; jerseys; shirts for infants, babies, toddlers and children; shorts; sweatpants; sweatshirts; t-shirts; tank tops.


Trademark
Hopkins Inc. | Date: 2014-09-15

Hooded sweatshirts; jackets; jeans; jerseys; shirts for infants, babies, toddlers and children; shorts; sweat pants; sweatshirts; t-shirts; tank tops.

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