Hopital Sainte Justine

Montréal, Canada

Hopital Sainte Justine

Montréal, Canada

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Halac U.,Hopital Sainte Justine | Noble A.,Hopital Sainte Justine | Faure C.,Hopital Sainte Justine
Journal of Pediatrics | Year: 2010

Objective: To evaluate the diagnostic value of the rectal sensory threshold for pain (RSTP) in children and adolescents with chronic abdominal pain. Study design: Fifty-one patients (25 girls; median age 14.2 years; range 8.4-17.6) with abdominal pain >2 months underwent a series of rectal distensions with an electronic barostat. RSTP and viscerosomatic referrals were assessed. Three months after the barostat, the final diagnosis was documented. Results: Thirty-five patients had a functional gastrointestinal disorder (FGID) (irritable bowel syndrome or functional abdominal pain), and 16 had an organic disease. RSTP was lower in the FGID group than in the organic disease group (25.4mm Hg vs 37.1mm Hg; P = .0002). At the cutoff of 30mm Hg, the RSTP measurement for the diagnosis of FGID had a sensitivity of 94% and a specificity of 77%. Both groups similarly reported aberrant viscerosomatic projections. Conclusion: In children, RSTP is a diagnostic marker of irritable bowel syndrome and functional abdominal pain. Viscerosomatic referrals are similar in children with FGID and organic diseases. © 2010 Mosby, Inc. All rights reserved.


Boileau B.,Hopital Sainte Justine | Boileau B.,University of Montréal
Dialogues in Clinical Neuroscience | Year: 2011

This article is a review of recent literature on obsessivecompulsive disorder in the pediatric population. Areas covered include: a brief historical perspective, clinical presentation in relation to symptoms found in different age groups, epidemiology, psychiatric comorbidity, etiology (with regards to genetics, neuroimaging, and familial factors), clinical course and prognosis, and treatment, with special emphasis on individual and family-based cognitive-behavioral therapy and psychopharmacology. © 2011, LLS SAS.


Castilloux J.,Hopital Sainte Justine | Noble A.J.,Hopital Sainte Justine | Faure C.,Hopital Sainte Justine
Journal of Pediatrics | Year: 2010

Objective: To describe short- (first year of age) and long-term (after 1 year of age) outcome in patients with esophageal atresia and identify early predictive factors of morbidity in the first month of life. Study design: Charts of children with esophageal atresia born January 1990 to May 2005 were reviewed. A complicated evolution was defined as the occurrence of at least 1 complication: severe gastroesophageal reflux, esophageal stricture requiring dilatations, recurrent fistula needing surgery, need for gavage feeding for ≥3 months, severe tracheomalacia, chronic respiratory disease, and death. Results: A total of 134 patients were included. Forty-nine percent of patients had a complicated evolution before 1 year of age, and 54% had a complicated evolution after 1 year. With bivariate analysis, predictive variables of a complicated evolution were demonstrated, including twin birth, preoperative tracheal intubation, birth weight <2500 g, long gap atresia, anastomotic leak, postoperative tracheal intubation ≥5 days, and inability to be fed orally by the end of the first month. After 1 year of age, the complicated evolution was only associated with long gap atresia and inability to be fed orally in the first month. A hospital stay ≥30 days was associated with a risk of a complicated evolution at 1 year and after 1 year of age (odds ratio, 9.3 [95% CI, 4.1-20.8] and 3.5 [95% CI, 1.6-7.6], respectively). Conclusion: Early factors are predictive of morbidity in children with esophageal atresia. © 2010 Mosby, Inc. All rights reserved.


Santschi M.,Université de Sherbrooke | Randolph A.G.,Boston Childrens Hospital | Rimensberger P.C.,University of Geneva | Jouvet P.,Hopital Sainte Justine
Pediatric Critical Care Medicine | Year: 2013

Objectives: The aim of this survey was to determine North American and European pediatric intensivists' knowledge and stated practice in the management of children with acute respiratory distress syndrome with regard to mechanical ventilation settings; blood gas and So2 targets; and use of adjunctive treatments at sites where actual practice had just been assessed. Design and Setting: A survey using three case scenarios to assess mechanical ventilation strategies used in children with acute respiratory distress syndrome was sent out toward the end of data collection to all centers participating in the Pediatric Acute Lung Injury Mechanical Ventilation study (59 PICUs in 12 countries). For each case scenario, intensivists were asked to report the optimal mechanical ventilation parameters; blood gas and So2 acceptable targets; and threshold for considering high-frequency oscillatory ventilation, and other adjunctive treatments. Participants: Fifty-four pediatric intensivists, representing 47 centers from 11 countries. Interventions: None. Measurements and Main Results: Many pediatric intensivists reported using a tidal volume of 5-8 mL/kg (88-96%) and none reported using a tidal volume above 10 mL/kg. On average, the upper threshold of positive inspiratory pressure at which intensivists would consider another ventilation mode was 35 cm H2O. Permissive hypercapnia and mild hypoxemia (So2 as low as 88%) was considered tolerable by many pediatric intensivists. Finally, a large proportion of pediatric intensivists reported they would use adjunctive treatments (nitric oxide, prone position, extracorporeal membrane oxygenation, surfactant, steroids, β-agonists) if the patient's condition worsened. Conclusions: Although in theory, many pediatric intensivists agreed with adult recommendations to ventilate with lower tidal volumes and pressure limits, the Pediatric Acute Lung Injury Mechanical Ventilation data revealed that over 25% of pediatric patients with acute lung injury/acute respiratory distress syndrome at many of these practice sites were ventilated with tidal volumes above 10 mL/kg and that high positive inspiratory pressure levels (> 35 mm Hg) were often tolerated. Copyright © 2013 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.


Saint-Pierre C.-A.,Ecole Polytechnique de Montréal | Boisvert J.,Ecole Polytechnique de Montréal | Grimard G.,Hopital Sainte Justine | Cheriet F.,Ecole Polytechnique de Montréal
Machine Vision and Applications | Year: 2011

This paper presents an algorithm that automatically detects and corrects specular reflections in thoracoscopic images and its application in the context of automatic segmentation of surgical tools. The detection is done by isolating the spike component of the specular reflection which is characterized by a bump at the end of the histogram of thoracoscopic images. The specular lobe is then extracted in the neighborhood of the spike component of the reflection. The result is a mask of the reflections positions in the image. Thereafter, the image is corrected using Oliveira et al.'s digital inpainting method. The automatic segmentation of surgical tools using the corrected images is then demonstrated. Results of the segmentation with and without the specular reflection elimination technique are compared. Moreover, 108 images extracted from 5 different surgeries performed under various conditions were considered to demonstrate the effectiveness of the proposed technique. © 2007 Springer-Verlag.


A method of classifying a human subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting an impairment in melatonin-signaling pathway in the sample in the presence and in the absence of a known melatonin-signaling pathway agonist, whereby the results of the detecting step enables the classification of the subject having AIS in one AIS subgroup; and a method of screening for a compound useful in the treatment of a disease characterized by a dysfunctional melatonin-signaling pathway, said method comprising the steps of contacting a candidate compound with at least one cell expressing at least one melatonin-signaling pathway impairment, wherein the candidate compound is selected if said melatonin-signaling pathway impairment is reduced in the presence of the candidate compound as compared to that in the absence thereof.


Patent
Hopital Sainte Justine | Date: 2011-06-21

A method for diagnosing an increased risk for developing adolescent idiopathic scoliosis (AIS) in a human subject, comprising detecting the presence or absence of at least one impairment in melatonin-signaling pathway in a cell sample of the subject in the presence and in the absence of a known melatonin-signaling pathway agonist, wherein the cell sample is selected from the group consisting of blood cell sample, osteoblast cell sample, osteoclast cell sample and myoblast cell sample, and wherein the presence of the at least one impairment in the melatonin-signaling pathway indicates that the subject possesses an increased risk for developing AIS.


Patent
Hopital Sainte Justine | Date: 2013-12-30

A method for diagnosing an increased risk for developing adolescent idiopathic scoliosis (AIS) in a human subject, comprising detecting the presence or absence of at least one impairment in melatonin-signaling pathway in a cell sample of the subject in the presence and in the absence of a known melatonin-signaling pathway agonist, wherein the cell sample is selected from the group consisting of blood cell sample, osteoblast cell sample, osteoclast cell sample and myoblast cell sample, and wherein the presence of the at least one impairment in the melatonin-signaling pathway indicates that the subject possesses an increased risk for developing AIS.


Patent
Hopital Sainte Justine | Date: 2012-10-15

A method of determining whether a subject is at risk of developing osteoarthritis (OA), said method comprising: determining the cellular localization of a Prohibitin-1 (PHB1) polypeptide and/or Small Ubiquitin-like Modifier (SUMO) polypeptide and/or UBC9, in a cell sample from said subject; and determining whether said subject is at risk of developing OA based on the cellular localization of a PHB1 polypeptide and/or SUMO and/or UBC9 polypeptide, is described.


A method of classifying a human subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting an impairment in melatonin-signaling pathway in the sample in the presence and in the absence of a known melatonin-signaling pathway agonist, whereby the results of the detecting step enables the classification of the subject having AIS in one AIS subgroup; and a method of screening for a compound useful in the treatment of a disease characterized by a dysfunctional melatonin-signaling pathway, said method comprising the steps of contacting a candidate compound with at least one cell expressing at least one melatonin-signaling pathway impairment, wherein the candidate compound is selected if said melatonin-signaling pathway impairment is reduced in the presence of the candidate compound as compared to that in the absence thereof.

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