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Van Bogaert P.,ULB Hopital Erasme
Handbook of Clinical Neurology | Year: 2013

Epileptic encephalopathy with continuous spike-waves during slow-wave sleep (CSWS) is a spectrum of epileptic conditions best defined by the association of cognitive or behavioral impairment acquired during childhood and not related to another factor other than the presence of abundant interictal epileptiform discharges (IED) during sleep, which tend to diffuse over the whole scalp. It is part of the childhood focal epileptic syndromes, some cases being idiopathic and overlapping with benign rolandic epilepsy, and others being symptomatic of a structural brain lesion. Landau-Kleffner syndrome (LKS) is a particular presentation where acquired aphasia is the core symptom. Clinical, neurophysiological, and cerebral glucose metabolism data support the hypothesis that IED play a prominent role in the cognitive deficits by interfering with the neuronal networks at the site of the epileptic foci but also at distant connected areas. Therefore, the treatment should aim to suppress IED. This may be achieved using conventional antiepileptic drugs, but corticosteroids seem to have more pronounced and sustained efficacy. Outcome for epilepsy is usually good, CSWS being an age-dependent EEG pattern, whereas outcome for cognition, language, and behavior is variable. Rehabilitation represents an important part of the treatment and visual forms of language should be encouraged in children with LKS. © 2013 Elsevier B.V. Source


Friman S.,Sahlgrenska University Hospital | Arns W.,Merheim Medical Center | Nashan B.,University of Hamburg | Vincenti F.,University of California at San Francisco | And 12 more authors.
American Journal of Transplantation | Year: 2011

Sotrastaurin, a selective protein-kinase-C inhibitor, blocks early T-cell activation through a calcineurin-independent mechanism. In this study, de novo renal transplant recipients with immediate graft function were randomized 1:2 to tacrolimus (control, n = 44) or sotrastaurin (300 mg b.i.d.; n = 81). All patients received basiliximab, mycophenolic acid (MPA) and steroids. The primary endpoint was the composite of treated biopsy-proven acute rejection (BPAR), graft loss, death or lost to follow-up at month 3. The main safety assessment was estimated glomerular filtration rate (eGFR); modification of diet in renal disease (MDRD) at month 3. Composite efficacy failure at month 3 was higher for the sotrastaurin versus control regimen (25.7% vs. 4.5%, p = 0.001), driven by higher BPAR rates (23.6% vs. 4.5%, p = 0.003), which led to early study termination. Median (± standard deviation [SD]) eGFR was higher for sotrastaurin versus control at all timepoints from day 7 (month 3: 59.0 ± 22.3 vs. 49.5 ± 17.7 mL/min/1.73 m2, p = 0.006). The most common adverse events were gastrointestinal disorders (control: 63.6%; sotrastaurin: 88.9%) which led to study-medication discontinuation in two sotrastaurin patients. © 2011 The American Society of Transplantation and the American Society of Transplant Surgeons. Source


Hocepied G.,Roosevelt University | Legros B.,ULB Hopital Erasme | Legros B.,Reference Center for the Treatment of Refractory Epilepsy | Van Bogaert P.,Reference Center for the Treatment of Refractory Epilepsy | And 2 more authors.
Computers in Biology and Medicine | Year: 2013

Physiologically based models are attractive for seizure detection, as their parameters can be explicitly related to neurological mechanisms. We propose an early seizure detection algorithm based on parameter identification of a neural mass model. The occurrence of a seizure is detected by analysing the time shift of key model parameters. The algorithm was evaluated against the manual scoring of a human expert on intracranial EEG samples from 16 patients suffering from different types of epilepsy. Results suggest that the algorithm is best suited for patients suffering from temporal lobe epilepsy (sensitivity was 95.0%±10.0% and false positive rate was 0.20±0.22 per hour). © 2013 Elsevier Ltd. Source


Fluss J.,Pediatric Neurology | Ferey S.,Pediatric Radiology | Menache-Starobinski C.,Pediatric Neurology | Delavelle J.,University of Geneva | And 2 more authors.
European Journal of Paediatric Neurology | Year: 2010

Mild influenza-associated encephalitis/encephalopathy with a reversible splenial lesion is a rare entity recently reported almost exclusively in Asiatic individuals. Hallmarks of this clinical-radiological syndrome include severe encephalopathy at onset, prompt and complete recovery, minimal to absent pleocytosis and rapidly reversible involvement of the splenium of the corpus callosum. We report herein a young Caucasian child who in addition had cerebellar involvement and presented a transient mutism during the recovery phase. © 2009 European Paediatric Neurology Society. Source


Salik D.,ULB Hopital Erasme | Del Marmol V.,ULB Hopital Erasme
Case Reports in Dermatology | Year: 2011

We report the case of a 35-year-old man with a chronic ulceration of the hand in whom an infection with Mycobacterium marinum was diagnosed. Clarithromycin and doxycycline were prescribed, resulting in a slow resolution of the ulceration. M. marinum is a nontuberculous mycobacterium that causes skin lesions such as nodules, ulcerations, and sporotrichoid spread, but may also be responsible for osteoarticular lesions. In this case report, we discuss the clinical characteristics of this condition, as well as its diagnostic methods and treatments. Copyright © 2011 S. Karger AG, Basel. Source

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