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Rantanen T.,University of Jyväskylä | Masaki K.,Honolulu Asia Aging Study at Kuakini Medical Center | Masaki K.,University of Hawaii at Manoa | He Q.,Honolulu Asia Aging Study at Kuakini Medical Center | And 7 more authors.
Age | Year: 2012

We studied prospectively the midlife handgrip strength, living habits, and parents' longevity as predictors of length of life up to becoming a centenarian. The participants were 2,239 men from the Honolulu Heart Program/Honolulu-Asia Aging Study who were born before the end of June 1909 and who took part in baseline physical assessment in 1965-1968, when they were 56-68 years old. Deaths were followed until the end of June 2009 for 44 years with complete ascertainment. Longevity was categorized as centenarian(≥100 years, n=47), nonagenarian (90-99 years, n=545), octogenarian (80-89 years, n=847), and ≤79 years (n=801, reference). The average survival after baseline was 20.8 years (SD=9.62). Compared with people who died at the age of ≤79 years, centenarians belonged 2.5 times (odds ratio (OR)=2.52, 95% confidence interval (CI)=1.23-5.10) more often to the highest third of grip strength in midlife, were never smokers (OR=5.75 95% CI=3.06-10.80), had participated in physical activity outside work (OR=1.13 per daily hour, 95% CI=1.02-1.25), and had a long-livedmother (≥80 vs. ≤60 years, OR=2.3, 95% CI=1.06-5.01). Associations for nonagenarians and octogenarians were parallel, but weaker. Multivariate modeling showed that mother's longevity and offspring's grip strength operated through the same or overlapping pathway to longevity. High midlife grip strength and long-lived mother may indicate resilience to aging, which, combined with healthy lifestyle, increases the probability of extreme longevity. © American Aging Association 2011.


PubMed | Honolulu Asia Aging Study at Kuakini Medical Center
Type: Comparative Study | Journal: Journal of Alzheimer's disease : JAD | Year: 2011

While animal data suggest a protective effect of caffeine on cognition, studies in humans remain inconsistent. We examined associations of coffee and caffeine intake in midlife with risk of dementia, its neuropathologic correlates, and cognitive impairment among 3494 men in the Honolulu-Asia Aging Study (mean age 52 at cohort entry, 1965-1968) examined for dementia in 1991-1993, including 418 decedents (1992-2004) who underwent brain autopsy. Caffeine intake was determined according to self-reported coffee, tea, and cola consumption at baseline. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for overall dementia, Alzheimers disease (AD), vascular dementia (VaD), cognitive impairment (Cognitive Abilities Screening Instrument score <74), and neuropathologic lesions at death (Alzheimer lesions, microvascular ischemic lesions, cortical Lewy bodies, hippocampal sclerosis, generalized atrophy), according to coffee and caffeine intake. Dementia was diagnosed in 226 men (including 118 AD, 80 VaD), and cognitive impairment in 347. There were no significant associations between coffee or caffeine intake and risk of cognitive impairment, overall dementia, AD, VaD, or moderate/high levels of the individual neuropathologic lesion types. However, men in the highest quartile of caffeine intake (>/=411.0 mg/d) [corrected] were less likely than men in the lowest quartile (

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