The Hong Kong Polytechnic University is a public university located in Hung Hom, Hong Kong. The history of PolyU can be traced back to 1937, and it assumed full university status in 1994. It is one of the funded institutions of the territory's University Grants Committee .PolyU has an international faculty and student community and has developed a global network with more than 440 institutions in 47 countries and regions. PolyU offers 220 postgraduate, undergraduate and sub-degree programmes for more than 32,000 students every year. It is the largest UGC-funded tertiary institution in terms of number of students. Wikipedia.
Hong Kong Polytechnic University | Date: 2017-02-06
The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.
Hong Kong Polytechnic University and McGill University | Date: 2016-10-18
A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters. The EC_(50 )values for reversing paclitaxel resistance (141-340 nM) of LCC6MDR cells, DOX (78-590 nM) and vincristine (82-550 nM) resistance of 2008/MRP1 cells and topotecan resistance (0.9-135 nM) of HEK293/R2 and MCF7-MX100 cells were at nanomolar range. Importantly, a number of compounds displayed EC_(50 )at or below 10 nM in BCRP-overexpressed cell lines, indicating that these bivalent triazoles more selectively inhibit BCRP transporter than the P-gp and MRP1 transporters. Most of the dimers are notably safe MDR chemosensitizers as indicated by their high therapeutic index values.
Hong Kong Polytechnic University | Date: 2017-08-16
A voltage balancing circuit is applied to a power supply system. The power supply system comprises N power storage devices. The voltage balancing circuit comprises: N switches, N capacitors and a controller; the N switches are respectively connected to the N serial power storage devices; the N switches are respectively connected to the first terminals of the N capacitors; the second terminals of the N capacitors are connected to a common neutral line; the controller is connected to the N switches through a control line to control the switching of the N switches. The voltage balancing circuit avoids power loss when balancing the voltage of a plurality of serial power storage devices, and is small in size and low-cost, and balances voltage quickly.
Hong Kong Polytechnic University | Date: 2016-07-26
This invention is in the preparation of bulk nanostructured pure titanium at cryogenic temperatures using equal channel angular pressing and rolling, allowing the whole microstructures of pure titanium to be refined into the one that the mean grain size is smaller than 100 nm.
News Article | May 9, 2017
Eldercare and Household Medical Products in the Spotlight The HKTDC Hong Kong International Medical Devices and Supplies Fair (Medical Fair) will take place at the Hong Kong Convention and Exhibition Centre (HKCEC) from 16 to 18 May. The largest Hong Kong medical fair organised to date, the eighth edition of the fair will gather 270 exhibitors from 14 countries and regions to showcase the latest medical equipment, technology and related services - providing a one-stop business platform for the medical industry. The three-day event is being organised by the Hong Kong Trade Development Council (HKTDC) and co-organised by the Hong Kong Medical and Healthcare Device Industries Association (HKMHDIA). - Good prospects for medical equipment and products Johnny Wan, HKTDC Exhibitions Market Development Director, said Hong Kong's total exports of medical and healthcare equipment reached HK$12.8 billion in 2016, an increase of 8.1 per cent over the previous year. The export value of such products in the first three months of this year reached HK$2.9 billion. HKMHDIA Chairman Ir Dr Andros Chan added that global demand for medical devices and supplies continues to rise. "According to the World Health Organization, annual global health expenditure is estimated at around US$6.5 trillion. Health expenditure as a share of GDP continues to grow in all major economies, including the Chinese mainland. This indicates immense market opportunities." The Medical Fair is an effective trading platform for the industry to grasp the business opportunities in this fast-growing market. This year, the fair will welcome new group pavilions from the US state of Illinois, the Czech Republic, India and Poland's Wielkopolska region. Returning pavilions include the Chinese mainland's Ningbo city, Pakistan and the HKMHDIA pavilion, which comprises about 30 companies. Exhibitors from Korea, Singapore and Thailand will also make their debut at the fair, further enriching the variety of medical equipment and devices on show. Last year's fair was well received, with more than 10,000 buyers taking part. This year, 38 international buying missions organised by the HKTDC are expected to bring in more than 1,000 buyers. - Debut of "World of Healthcare" and "Startup" zones The Medical Fair will feature a wide spectrum of medical and healthcare equipment and related services, organised into more than 15 specialised product zones for easy sourcing. Responding to growing awareness of the importance of healthcare, "World of Healthcare" will be introduced at the fair to present healthcare products and services, including fitness products, health food and beverages, and nutrition supplements. The medical industry is also becoming a popular sector for entrepreneurs. In line with the government's policy to promote entrepreneurship, the fair will feature a new "Startup" zone, to showcase innovative medical products from Hong Kong start-ups. "In recent years, many young entrepreneurs are dedicated to developing medical products and technologies and bringing new products and ideas to market. Therefore, the Medical Fair is introducing the Startup zone to connect them with buyers and potential business partners and explore more opportunities," said Mr Wan. - Eldercare and household medical products in the spotlight According to the United Nations, the total global population is estimated at around 7.5 billion people, with 960 million or 13 per cent of the total population aged 60 or above. To keep pace with rising demand in the "silver market," the Rehabilitation and Elderly Care zone will showcase products and services for general care and rehabilitation after illness or injury among elderly people. Products to feature include an exercise machine equipped with various muscle-training programmes that improves respiratory and cardiovascular system functions of patients with Parkinson's disease, as well as an innovative tank-top developed by the Hong Kong Polytechnic University. The vest features a bio-feedback system with multiple sensors used to treat scoliosis. As household medical products and services grow more popular, many companies have launched products specific to the household market. The Household Medical Products zone, another fair highlight, will showcase various household medical devices, including an electrocardiograph smart watch band that can facilitate immediate diagnosis and treatment of heart disease. With new innovations in medical technology, there is growing demand for diagnostic and surgical equipment. The Hospital Equipment zone will showcase specialist equipment and technology, including ultrasound and imaging tools, as well as a range of surgical instruments. The fair's Physiotherapy zone will present the latest physiotherapy equipment, devices and related services and products, including a therapy mattress, therapy light, physiotherapy plinth and physiotherapy massage equipment. - Seminars to analyse market trends To help industry professionals monitor the pulse of the market and expand their business networks, a series of seminars will be held at the fair. Industry experts will discuss topics ranging from the latest market trends and product innovations to worldwide medical device regulatory updates. The Czech Republic pavilion, participating in the fair for the first time, will also invite professionals to present an overview of the Czech medical market and their latest medical equipment and services. Three workshops, co-organised by the Hong Kong Doctors Union and the Hong Kong Health Care Federation, will cover such topics as cervical cancer prevention and HPV infection, and the latest information on coronary angioplasty. The Medical Fair has strong synergy with the concurrent Hospital Authority Convention 2017, to be held on the first two days of the fair (16-17 May). More than 5,000 delegates are expected to attend the Convention, making it one of Asia-Pacific's largest events for medical professionals. Hong Kong International Medical Devices and Supplies Fair: www.hktdc.com/hkmedicalfair/ Product Highlights: http://bit.ly/2pqlIyN Photo Download Link: http://bit.ly/2pfi92u To view press releases in Chinese, please visit http://mediaroom.hktdc.com/tc (Photo:) HKTDC Exhibitions Market Development Director Johnny Wan (Left) and HKMHDIA Chairman Ir Dr Andros Chan (Right) introduced highlights of the Medical Fair at today's press conference. About HKTDC Established in 1966, the Hong Kong Trade Development Council (HKTDC) is a statutory body dedicated to creating opportunities for Hong Kong's businesses. With more than 40 offices globally, including 13 on the Chinese mainland, the HKTDC promotes Hong Kong as a platform for doing business with China, Asia and the world. With 50 years of experience, the HKTDC organises international exhibitions, conferences and business missions to provide companies, particularly SMEs, with business opportunities on the mainland and in international markets, while providing information via trade publications, research reports and digital channels including the media room. For more information, please visit: www.hktdc.com/aboutus. Follow us on Google+, Twitter @hktdc, LinkedIn. Google+: https://plus.google.com/+hktdc Twitter: http://www.twitter.com/hktdc LinkedIn: http://www.linkedin.com/company/hong-kong-trade-development-council Contact:
Hoya Lens Thailand Ltd. and Hong Kong Polytechnic University | Date: 2015-11-06
A spectacle lens can inhibit ametropia of the eyes and ensure full visibility. The spectacle lens comprises: first refraction areas and second refraction areas. Each first refraction area has a first refraction force that may be based on a prescription for correcting the ametropia of the eyes. Each second refraction area has a refraction force different from the first refraction force and may function to focus images on the positions except the retina of the eyes, to inhibit the development of the ametropia. Near the central part of the lens, the second refraction areas form a plurality of independent island-shaped areas, and the first refraction areas form the areas beyond the areas of the second refraction areas.
News Article | May 9, 2017
PolyU's novel bio-inspired anti-vibration structures has won the 2017 TechConnect Global Innovation Award. PolyU is the first tertiary institution in Hong Kong receiving this award, with 3 innovation projects snatching the honor. Credit: The Hong Kong Polytechnic University The Department of Mechanical Engineering of The Hong Kong Polytechnic University (PolyU) has developed a novel bio-inspired nonlinear anti-vibration system that can significantly reduce vibration in mechanical systems. The system is better than existing devices in cost-efficiency and performance reliability, and has many applications. Inspired by the motion vibration control of the limb structures of birds and insects, the novel X-shaped system demonstrates nearly zero response to any vibration (quasi-zero low dynamic stiffness), but simultaneously exhibits high loading capacity. It also features automatic high damping for strong vibrations, and low damping for small vibrations, thus preventing high damping's adverse effect on a system's normal functioning during small vibration. These advantages stem from the novel system's nonlinearity—a unique feature lacking in most vibration control systems today, which are usually following linear system design. The novel system can therefore be applied very widely in engineering practices and vibration control devices. As a first step in transferring the innovation into daily life benefit, the research team led by Dr Xingjian Jing, associate professor of the department, has obtained funding, facilities and trial support from the construction sector to develop an assistive anti-vibration exoskeleton for hand-held jackhammers. With superb anti-vibration performance, the new device can prevent hand-arm occupation diseases among construction workers. Using the new device, the vibration of hands and arms in drilling concrete ground can be significantly suppressed to the ideal safety level, compared with many commonly-used jackhammers on the market. The very low cost for manufacturing and maintenance, and its great design flexibility for adapting to devices of different sizes and materials, can also enhance its potential applications. At present, the market price of a common passive control jackhammer is around HK$1,000. It is estimated that PolyU's assistive anti-vibration exoskeleton added to such passive control system will need only an additional HK$1,000 to $2,000, offering performance far exceeding high-quality active control devices that cost about HK$,10,000 to 40,000. Explore further: E-gloves to protect workers from dangerous vibration levels
News Article | May 9, 2017
The Department of Mechanical Engineering of The Hong Kong Polytechnic University (PolyU) has developed a novel bio-inspired nonlinear anti-vibration system that can significantly reduce vibration in various mechanic systems. The innovation far excels existing devices in cost-efficiency and performance reliability, and can have very wide applications. Inspired by the limb structures of birds and insects in motion vibration control, the novel X-shaped system is of capability to demonstrate nearly “zero response” to any vibration (quasi-zero low dynamic stiffness), but simultaneously of high loading capacity. It also features automatic high damping for strong vibration, and low damping for small vibration (thus preventing high damping’s adverse effect on a system’s normal functioning during small vibration). These advantages stem from the novel system’s nonlinearity – a unique feature lacking in most vibration control systems nowadays which are usually following linear system design. The novel system can therefore be applied very widely in various engineering practices and vibration control devices. As a first step in transferring the innovation into daily life benefit, the research team led by Dr Xingjian Jing, Associate Professor of the department, has obtained funding, and facilities and trial support from the construction sector, to embark on research in applying the patented novel system to build an assistive anti-vibration exoskeleton for hand-held jackhammers. With superb anti-vibration performance, the new device can markedly help prevent hand-arm occupation diseases among construction workers. Using the new device, the vibration at hand/arm in drilling concrete ground can be significantly suppressed to the ideal safety level, compared with many commonly-used jackhammers in the market. The very low cost in manufacturing and maintenance, with great design flexibility for adapting to devices of different sizes and materials, can also enhance its potential popular use. At present, the market price of a common passive control jackhammer is around HK$1,000. It is estimated that PolyU’s assistive anti-vibration exoskeleton added to such passive control system will need only an additional HK$1,000 - 2,000, yet with performance far excelling even good-quality active control device that cost about HK$,10,000 - 40,000. Dr Jing’s innovative bio-inspired system is one of the three PolyU innovations having won the TechConnect Global Innovation Awards 2017. It is the first time for a Hong Kong higher education institution to receive the awards, along with other global-renowned research institutes (including US NASA, National Labs, Georgia Tech, Princeton Lab, UCLA, Australia National U etc), at the TechConnect World Innovation Conference and Expo, the largest multi-sector summit for supporting the development and commercialization of innovations. The annual event held in the US gathers more than 4,000 technology innovators, ventures, industrial partners and investors from over 70 countries. Only the top 20% of innovations submitted to TechConnect World will receive awards, with assessment based on the potential positive impact the submitted technology will have on a specific industry sector. PolyU is the only awardee from Hong Kong, and snatches 3 out of the 26 global awards presented to non-US-federal-funded innovations across the world. Another 60 national awards are granted to innovations with US federal funding. The PolyU delegation will present their innovations and receive the awards in mid-May at TechConnect World conference and expo held in Washington DC. For details of the award, please visit its official website: http://www.techconnectworld.com/World2017/participate/innovation/awards.html Vibration can be controlled by passive systems, which isolate or mitigate vibration by passive techniques (e.g. rubber pads, mechanical springs, shock absorbers, base isolation), or via active systems, which apply force or energy in an equal and opposite fashion to the vibration force. In general, passive vibration control is most preferred in engineering practices, as its manufacturing, operating and maintenance cost is much lower than active system. It also consumes less energy, and is easier to repair, less complex and thus more reliable. However, the vibration control performance of active systems is much better. The PolyU novel bio-inspired X-shaped structure possesses all the benefits of the passive and active systems. It has superior nonlinear stiffness and damping characteristics which can suppress vibration transmission and/or absorb vibration energy dramatically in a beneficial nonlinear manner. The system thus has great potential in wide applications, other than applying in vibrating tools, such as jackhammers which is already undergoing research study by Dr Jing’s team. Amidst the many spectra the novel system can be applied include robotics, railways, vehicle suspension, precise machines, offshore platforms, marine engineering, aeronautic engineering, and various civil structures like bridges, buildings, etc.
Lin P.,Hong Kong Polytechnic University |
Yan F.,Hong Kong Polytechnic University
Advanced Materials | Year: 2012
Organic thin-film transistors (OTFTs) show promising applications in various chemical and biological sensors. The advantages of OTFT-based sensors include high sensitivity, low cost, easy fabrication, flexibility and biocompatibility. In this paper, we review the chemical sensors and biosensors based on two types of OTFTs, including organic field-effect transistors (OFETs) and organic electrochemical transistors (OECTs), mainly focusing on the papers published in the past 10 years. Various types of OTFT-based sensors, including pH, ion, glucose, DNA, enzyme, antibody-antigen, cell-based sensors, dopamine sensor, etc., are classified and described in the paper in sequence. The sensing mechanisms and the detection limits of the devices are described in details. It is expected that OTFTs may have more important applications in chemical and biological sensing with the development of organic electronics. Organic thin-film transistors, including organic field-effect transistors and organic electrochemical transistors, can be used in various types of chemical and biological sensors, such as pH, humidity, ion, glucose, DNA, enzyme, antibody-antigen, cell and dopamine sensors. The organic transistors are expected to have more important sensing applications with the development of organic electronics. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Huang K.,Hong Kong Polytechnic University
IEEE Transactions on Information Theory | Year: 2013
Designing mobiles to harvest ambient energy such as kinetic activities or electromagnetic radiation will enable wireless networks to be self-sustaining. In this paper, the spatial throughput of a mobile ad hoc network powered by energy harvesting is analyzed using a stochastic-geometry model. In this model, transmitters are distributed as a Poisson point process and energy arrives at each transmitter randomly with a uniform average rate called the energy arrival rate. Upon harvesting sufficient energy, each transmitter transmits with fixed power to an intended receiver under an outage-probability constraint for a target signal-to-interference-and-noise ratio. It is assumed that transmitters store energy in batteries with infinite capacity. By applying the random-walk theory, the probability that a transmitter transmits, called the transmission probability, is proved to be equal to the smaller of one and the ratio between the energy-arrival rate and transmission power. This result and tools from stochastic geometry are applied to maximize the network throughput for a given energy-arrival rate by optimizing transmission power. The maximum network throughput is shown to be proportional to the optimal transmission probability, which is equal to one if the transmitter density is below a derived function of the energy-arrival rate or otherwise is smaller than one and solves a given polynomial equation. Last, the limits of the maximum network throughput are obtained for the extreme cases of high energy-arrival rates and sparse/dense networks. © 1963-2012 IEEE.