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Seto W.H.,Hong Kong Baptist Hospital | Yuen S.W.S.,Infection Control Unit | Cheung C.W.Y.,Infection Control Unit | Ching P.T.Y.,Infection Control Unit | And 2 more authors.
American Journal of Infection Control | Year: 2013

Campaign fatigue was evident in a large hospital in Hong Kong when hand hygiene compliance remained just above 50% after 4 years of aggressive and varied promotional activities. A new innovative strategy was developed that directly involved the infection control link nurses both in formulating the strategy and in implementing the various proposed programs. The new strategy was successful in increasing hand hygiene compliance to 83%. © 2013 by the Association for Professionals in Infection Control and Epidemiology, Inc. Source

Ma S.,Hong Kong Baptist Hospital | Ma C.C.-H.,NHS Dumfries & Galloway
Vascular pharmacology | Year: 2014

Since the discovery of the importance of nitric oxide (NO) to the human body three decades ago, numerous laboratory and clinical studies have been done to explore its potential therapeutic actions on many organs. In the cardiovascular system, NO works as a volatile signaling molecule regulating the vascular permeability and vascular tone, preventing thrombosis and inflammation, as well as inhibiting the smooth muscle hyperplasia. Thus, NO is important in the prevention and treatment of cardiovascular disease. NO is synthesized by NO synthase (NOS) with tetrahydrobiopterin (BH4) as the crucial cofactor. Many studies have been done to form nitric oxide donors so as to deliver NO directly to the vessel walls. In addition, NO moieties have been incorporated into existing therapeutic agents to enhance the NO bioavailability, including statins. Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA), the rate-limiting enzyme of the mevalonate pathway. By inhibiting this pathway, statins lower blood cholesterol and exert their pleiotropic effects through activity in reaction cascades, such as Rho/ROCK and Rac 1/NADPH oxidase pathways. Statins have also been observed to implement their non-lipid effects by promoting BH4 synthesis with increase of NO bioavailability. Furthermore, NO-donating statins in laboratory studies have demonstrated to produce better therapeutic effects than their parent's drugs. They offer better anti-inflammatory, anti-proliferative and antithrombotic actions on cardiovascular system. They also cause better revascularization in peripheral ischemia and produce greater enhancement in limb reperfusion and salvage. In addition, it has been shown that NO-donating statin caused less myotoxicity, the most common side effect related to treatment with statins. The initial studies have demonstrated the superior therapeutic effects of NO-donating statins while producing fewer side effects. Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved. Source

Chan S.Y.-Y.,Chinese University of Hong Kong | To K.-F.,Chinese University of Hong Kong | Leung S.-F.,Chinese University of Hong Kong | Yip W.W.-L.,Hong Kong Baptist Hospital | And 3 more authors.
Oncology Reports | Year: 2010

In this study, we investigated the expression of 14-3-3σ tumor suppressor gene in a panel of NPC cell lines, xenografts and primary tumors. Our objective was to determine the correlation between 14-3-3σ expression and clinical outcome in NPC. We detected reduced 14-3-3σ expression in 5/6 NPC tumor lines by quantitative RT-PCR and Western blotting. By immunohistochemical staining, significant downregulation of 14-3-3σ was also found in 26/72 (36.1%) primary tumors of NPC patients, who were treated with curative radiotherapy. Promoter methylation was confirmed in a subset of primary tumors by methylation-specific PCR analysis. Importantly, we demonstrated that 14-3-3σ expression is significantly associated with both overall survival (OS) and cancer-specific survival (CSS), but not with the clinical staging of NPC patients. The low 14-3-3σ expression was associated with improved overall (p=0.029) and cancer-specific survival (p=0.042) on univariate analysis. 14-3-3σ expression and staging were also independent variables to all the prognostic factors under multi-variate analysis. In conclusion, low expression of 14-3-3σ appears to be a valuable marker for better survival in patient with NPC. These results provide the evidence that 14-3-3σ expression is a significant prognostic factor for NPC patients. Source

Seto W.H.,Hong Kong Baptist Hospital | Cowling B.J.,University of Hong Kong | Cheung C.W.Y.,Infection Control Unit | Wong C.Y.Y.,Infection Control Unit | And 3 more authors.
American Journal of Infection Control | Year: 2015

Staff of a large hospital in Hong Kong attempted and set the first Guinness World Record for the most participants in a hand sanitizing relay in May 2014. After this event, average compliance with hand hygiene increased from 72% (95% CI, 70%-74%) in 2013 to 85% (95% CI, 83%-87%) in June-July 2014, and the conceptual understanding of good hand hygiene practices improved. © 2015 Association for Professionals in Infection Control and Epidemiology, Inc. Source

Yan C.M.,Hong Kong Baptist Hospital
Hong Kong Medical Journal | Year: 2010

The laparoscopic management of three rare types of ectopic pregnancy, including rudimentary horn pregnancy, caesarean scar pregnancy, and interstitial pregnancy is described. All were managed with little morbidity. When the appropriate facilities and skills are available, laparoscopic surgery is the surgical treatment of choice for the various types of ectopic pregnancy. Source

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