Sandomierz, Poland
Sandomierz, Poland

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Brola W.,Specialist Hospital | Sobolewski P.,Holy Spirit Specialist Hospital | Fudala M.,Specialist Hospital | Flaga S.,AGH University of Science and Technology | And 3 more authors.
Patient Preference and Adherence | Year: 2016

Background: The aim of the study was to analyze selected clinical and sociodemographic factors and their effects on the quality of life (QoL) of multiple sclerosis (MS) patients registered in the Polish MS Registry. Methods: This was a cross-sectional observational study performed in Poland. Data on personal and disease-specific factors were collected between January 1, 2011, and December 31, 2015, via the web portal of the Polish MS Registry. All patients were assessed by a physician and asked to complete the Polish language versions of the following self-evaluation questionnaires: EuroQol 5-Dimensions, EuroQoL Visual Analog Scale, and Multiple Sclerosis Impact Scale. Univariate analysis and logistic regression were performed to determine the factors associated with QoL. Results: The study included 2,385 patients (female/male ratio 2.3:1) with clinically confirmed MS (mean age 37.8±9.2 years). Average EuroQol 5-Dimensions index was 0.72±0.24, and the mean EuroQoL Visual Analog Scale score was 64.2±22.8. The average Multiple Sclerosis Impact Scale score was 84.6±11.2 (62.2±18.4 for physical condition and 23.8±7.2 for mental condition). Lower QoL scores were significantly associated with higher level of disability (odds ratio [OR], 0.932; 95% confidence interval [CI], 0.876-0.984; P=0.001), age>40 years (OR, 1.042; 95% CI, 0.924-1.158; P=0.012), longer disease duration (OR, 0.482; 95% CI, 0.224-0.998; P=0.042), and lack of disease modifying therapies (OR, 0.024; 95% CI, 0.160-0.835; P=0.024). No significant associations were found between QoL, sex, type of MS course, patient’s education, and marital status. Conclusion: The Polish MS Registry is the first national registry for long-term observation that allows for self-evaluation of the QoL. QoL of Polish patients with MS is significantly lower compared with the rest of the population. The parameter is mainly affected by the level of disability, duration of the disease, and limited access to immunomodulatory therapy. © 2016 Brola et al.


Sobolewski P.,Holy Spirit Specialist Hospital | Szczuchniak W.,Holy Spirit Specialist Hospital | Wach-Klink A.,Holy Spirit Specialist Hospital | Grzesik M.,Holy Spirit Specialist Hospital
Experimental and Clinical Cardiology | Year: 2014

Background: The aim of this publication is to present the possibilities of intravenous thrombolysis (iv-thrombolysis) with use of rt-PA in patients with concomitant massive AIS and acute MI and in patients with stroke after percutaneous coronary intervention (PCI). Material and methods: We retrospectively evaluated the demographic and clinical data of 287 Caucasian patients with AIS who were consecutively treated with ivthrombolysis from January 2008 to December 2012. Results: At the time of admission in four patients MI was diagnosed and in two patients AIS occurred during diagnostic coronarography. All patients with AIS and coexisting MI survived, and two of them had favorable outcome after 3 months. In one case after coronarography, parenchymal hemorrhage type 2 was diagnosed, but both patients were independent at 90th day after iv-thrombolysis. We present 2 cases illustrating both therapeutic problems. Conclusions: Our data on the small group of patients suggest that IV-thombolysis with use of rt-PA in patients with concomitant AIS and MI may be considered as a beneficial method of treatment for both diseases. Morever, in selected cases, in patients with AIS after PCI, systemic cerebral thrombolysis can be used, despite numerous risks. © 2013 et al.; licensee Cardiology Academic Press.

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