Thiruchirappalli, India
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Ruby Nirmala L.,Holy Cross College Autonomous | Thomas Joseph Prakash J.,Hh The Rajahs College Autonomous
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

Potassium Chloride (KCl) as an additive is added into zinc thiourea chloride solution in a small amount (1 M%) by the method of slow evaporation solution growth technique at room temperature to get a new crystal. Due to the doping of the impurities on the crystals, remarkable changes in the physical properties were obtained. The grown crystals have been subjected to different instrumentation methods. The incorporation of the amount of potassium and zinc in the crystal lattices has been determined by AAS method. The lattice dimensions have been identified from single crystal X-ray diffraction measurements. The presence of functional group for the grown crystals has been identified by FTIR analysis. The optical, thermal and mechanical behaviors have been assessed by UV-Vis, TG/DTA and Vickers hardness methods respectively. The presence of dislocations of atoms has been identified by etching studies. © 2012 Elsevier B.V. All rights reserved.


Ruby Nirmala L.,Holy Cross College Autonomous | Thomas Joseph Prakash J.,Hh The Rajahs College
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2012

Single crystals of pure bis thiourea zinc acetate (BTZA) and lithium chloride (LiCl) doped BTZA have been synthesized and grown successfully from aqueous solutions by slow evaporation technique. The single crystals thus grown were characterized by different techniques such as single crystal XRD, AAS, FT-IR, UV-Vis, TG/DTA and SHG test. The single crystal XRD study proved that the dopant has not changed the structure of the parent crystal. The AAS study confirmed the presence of lithium in the doped crystal. The FTIR study ascertained the metal coordination of lithium chloride doped BTZA through thiourea. The optical behavior of the doped crystal has been examined by UV spectral analysis. Thermal studies TGA & DTA of the doped crystal have been investigated and found that the doped crystal is thermally more stable than the pure crystal. The SHG test using Nd: YAG Laser confirmed the NLO activity of the pure and doped crystal. The obtained results are presented and discussed. © 2012 Elsevier B.V. All rights reserved.


Vimala J.R.,Holy Cross College Autonomous | Raja S.,St. Joseph's College
Research Journal of Chemistry and Environment | Year: 2013

The inhibition of corrosion of mild steel using Vitex negundo extract in 1M HCl and DD water solutions was investigated by weight loss method at 30°C. The result showed that corrosion rate was significantly decreased in presence of the extract and inhibition efficiency increased with increasing the concentration of extract. In case of HCl maximum inhibition efficiency (86.39%) was noticed at 95 ppm inhibitor concentration and in DD water, it was found 92.86% efficiency at the same concentration of inhibitor. At lower concentration of inhibitor, better inhibition was observed in DD water medium as compared to HC. Polarization study reveals that this formulation controls the cathodic reaction predominantly. AC impedance spectra reveal that a protective film is formed on the metal surface. The decreased corrosion rate was due to adsorption of plant extract which was discussed on the basis of polarization and AC impedance measurements. Adsorption of Vitex negundo depends on its chemical composition which showed the presence of various compounds like flavonoids, steroids, tannins and phenolic compounds etc. which have oxygen atoms with lone pair electrons for co-ordinate bonding with metal.


Pitchai D.,Holy Cross College Autonomous | Manikkam R.,Holy Cross College Autonomous
Medicinal Chemistry Research | Year: 2012

A study of ancient literature indicates that diabetes was fairly well known and well conceived as an entity in India. The nature has provided abundant plant wealth for all the living creatures, which possess medicinal virtues. Therefore, there is a necessity to explore their uses and to conduct pharmacognostic and pharmacological studies to ascertain their therapeutic properties. In fact, nowadays diabetes is a global problem. Hence, this study aims to open new avenues for the improvement of medicinal uses of catechin isolated from the methanol extract of Cassia fistula stem bark for the selected area of diabetes. Oral administration of catechin (20 mg/kg b.wt) for 60 days produce a better glucose tolerance pattern in Streptozotocin-induced diabetic male albino Wistar rats. Another important objective of the study is to bring the implication of computer-aided drug development. In biomedical arena, computer-aided or in silico design is being utilized to expedite and facilitate hit identification, hit-tolead selection, optimize the absorption, distribution, metabolism, excretion and toxicity profile, and avoid safety issues. Commonly used computational approaches include ligand-based drug design (pharmacophore, a 3-D spatial arrangement of chemical features essential for biological activity), structure-based drug design (drug target docking), and quantitative structure-activity and quantitative structure-property relationships. The 3D structure of the catechin was docked with the receptors (PPARγ and insulin receptor) by Discovery Studio 2.1 version (An Accelery's product). The results show that catechin possesses a potential agonist characteristic that is capable of activating Insulin receptor and Peroxisome proliferator-activated receptor gamma. These results confirm the hypoglycemic effect of catechin. We can conclude that catechin could be developed into potential oral hypoglycemic drug. © Springer Science+Business Media, LLC 2011.


Ida C.J.,Holy Cross College Autonomous
Asian Journal of Microbiology, Biotechnology and Environmental Sciences | Year: 2013

The purpose of this study was to evaluate the efficacy of various extracts of stem of Cissus quadrangularis and fruits of Terminalia chebula against some food poisoning bacteria such as Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa and Escherichia coli. The antibacterial activity of different solvent extracts (ethyl acetate and methanol) of these plants was determined by using disc diffusion method. Results revealed that ethyl acetate extract of C.quadrangularis exhibited significant antibacterial activity against all the tested bacteria except P. aeruginosa. The methanolic extract of T. chebula showed maximum zone of inhibition against the bacteria B. cereus. From the present study it is clear that these two plants may have the potential to be used as natural medicine against food poisoning bacteria. However there is a need for further research to isolate the bio-active compounds responsible for antibacterial activity. © Global Science Publications.


Sumathi P.,Holy Cross College Autonomous | Parvathi A.,Holy Cross College Autonomous
Journal of Medicinal Plants Research | Year: 2010

The present investigation is focused on antibacterial potential of dimethyl sulphoxide (DMSO) extracts from fruits of Emblica officinalis Gaertn., Terminalia bellerica Roxb. and Terminalia chebula Retz. against Salmonella typhi (32 strains) isolated from different human pathogens in agar dilution technique. DMSO fruit extracts of E. officinalis showed potent antimicrobial activity against S. typhi whereas T. bellerica was found to be highly effective against S. typhi. Crude fruit extract of T. chebula also showed significant antibacterial activity against 32 different strains of S.typhi. © 2010 Academic Journals.


Sumathi P.,Holy Cross College Autonomous | Parvathi A.,Holy Cross College Autonomous
Journal of Medicinal Plants Research | Year: 2010

The antimicrobial activity of the extracts of Andrographis paniculata Nees; Phyllanthus niruri Linn.; Terminalia bellerica Roxb.; Terminalia chebula Retz.; and Vitex negundo Linn., was studied against four gram negative and one gram positive bacteria. The results showed that the minimum inhibitory concentration (MIC) of P. niruri leaf extract was 50 μg/ml against Salmonella typhi and Staphylococcus aureus, where as, the MICs of T. bellerica fruit extract against Escherichia coli and S. aureus were 50 and 200 μg/ml respectively. However, the leaf extracts of the Andrographis paniculata, T. chebula and V. negundo have not shown any antimicrobial activity in the tested concentrations. © 2010 Academic Journals.


Selvarani D.R.,Holy Cross College Autonomous | Ravi T.N.,Holy Cross College Autonomous
Proceedings of the 2016 IEEE International Conference on Wireless Communications, Signal Processing and Networking, WiSPNET 2016 | Year: 2016

The mechanism of efficiently managing power energy is becoming highly significant due to the mobile nature of IEEE802.16e as well as the battery dependency of mobile devices. IEEE802.16e advocates a sleep mode facility so that the power consumption of a Mobile Station (MS) is minimized. As there is no need for MS to send packet always to its base station (BS), both can come to a common agreement that the MS can temporarily go to sleep mode. During the sleep interval, if there is any traffic pending, BS will inform it through MOB-TRF-IND message. When going into sleep mode and getting back to awake mode, MS needs to spend some energy. If an attacker copies a valid MOB-TRF-IND and transmit it to a sleeping MS again and again, he/she will be draining the battery energy of the affected MS at a maximum level. If the energy is not efficiently managed and the battery power of MS is completely drained, it leads to Denial of Service (DoS) attack. Therefore care should be taken to satisfy the security requirement called Availability. In this paper, secured MOB-TRF-IND message is implemented using X.509 certificate so that an attacker cannot do any malpractices in order to exhaust the energy resources of the victim MS. © 2016 IEEE.


Shanthi P.,Holy Cross College Autonomous | Amudha P.,Holy Cross College Autonomous
International Journal of Pharma and Bio Sciences | Year: 2010

Acmella calva (DC.) R.K.Jansen., commonly known as toothache plant was analyzed for their chemical composition and minerals. The various extracts of the plant parts (leaves, inflorescence and whole plant) possessed the presence of active phytochemical constituents such as alkaloids, glycosides, flavanoids, reducing sugar, tannins, anthraquinone, saponins and cardiac glycosides. The amount of total soluble protein (0.78±0.09 mg/g) and the total free amino acids (14.95±1.00 mg/g) was remarkably high in the inflorescence. In the whole plant, the carbohydrates content was (6.66±0.35 mg/g) estimated in high quantity. The secondary plant products such as phenols (6.14±0.46 mg/g) and tannins (2.63±0.06 mg/g) were found maximum in the leaves. The herb is a good source of minerals. The maximum amount of nitrogen (0.24±0.15 mg/g) and phosphorus (0.06±0.07 mg/g) was obtained in the inflorescence and the iron (2.67±0.05 mg/g) content was recorded high in the leaves.


Rajalakshmi M.,Holy Cross College Autonomous | Anita R.,Holy Cross College Autonomous
Chemico-Biological Interactions | Year: 2016

The use of herbal supplements either as extracts or plant-derived individual molecules has significantly increased in the process of drug discovery and development for their potential efficacy or reduced risk in treating human disorders. Tinospora cordifolia (T. cordifolia) is a widely used herbal source to treat various human ailments, including diabetes mellitus. The present study was aimed on evaluating the antidiabetic property of a novel polysaccharide isolated from the methanolic extract of T. cordifolia stem. Bioassay guided fractionation was followed to isolate a compound from the methanol extract. The compound was administered orally at a dose of 20 mg/kg.b.wt for 60 days to control and STZ-induced diabetic male Wistar rats. It was found that plasma glucose was significantly (p < 0.05) reduced compared to normal. Oral administration of the compound significantly decreased HBA1c, triglycerides and total cholesterol and at the same time markedly increased hemoglobin, tissue glycogen and HDL cholesterol. Also the compounds restored the altered carbohydrate metabolizing enzymes, insulin, C-peptide, 14C-glucose oxidation levels to near normal. In addition, the histological studies revealed that there was regeneration of β-cells in the pancreatic sections. The expression of Glut-4 mRNA and protein in the gasrtocnemius muscle were significantly enhanced after the compound treatment. These results confirm that the novel polysaccharide possesses hypoglycemic, glucose oxidizing, hypolipidemic and β-cell regenerative properties and hence it could be developed into potential oral hypoglycemic drug with lesser side effects. © 2015 Elsevier Ireland Ltd. All rights reserved.

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