Holy Cross College Autonomous

Thiruchirappalli, India

Holy Cross College Autonomous

Thiruchirappalli, India
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Latha R.C.R.,Holy Cross College Autonomous | Daisy P.,Holy Cross College Autonomous
International Journal of Pharmacology | Year: 2010

Terminalia bellerica Roxb. is extensively used in Indian traditional systems of medicine to treat various diseases including diabetes mellitus. The present study investigated the antidiabetic effects of Terminalia bellerica fruit extracts and their protective effect in preventing the secondary complications of diabetes mellitus. Hexane, ethylacetate and methanol crude extracts of Terminalia bellerica fruits were administered at the dose of 200, 300 and 300 mg kg-1, respectively, for 60 days to Streptozotocin induced diabetic male Wistar rats. It was found that the fruit extracts significantly (p<0.05) increased the plasma insulin, C-peptide and glucose tolerance levels compared to the diabetic control and the effect was more pronounced in methanol extract treated rats. In addition the plant extracts significantly (p<0.05) increased body weight and serum total protein and significantly decreased the serum levels of total cholesterol, triglycerides, low density lipoprotein cholesterol, urea, uric acid and creatinine in diabetic rats. Thus the results of this experimental study indicated that Terminalia bellerica fruit extracts restored all the biochemical parameters related to the patho-biochemistry of diabetes mellitus and prevented diabetic nephropathy, dyslipidemia and other diabetes-induced complications. These beneficial therapeutic effects of Terminalia bellerica fruits may be due to the synergistic action of more than one bioactive compound and due to the significantly increased C-peptide in extract treated diabetic rats. © 2010 Asian Network for Scientific Information.


Rosy B.A.,Holy Cross College Autonomous | Rosakutty P.J.,Holy Cross College Autonomous
Journal of Chemical and Pharmaceutical Research | Year: 2012

The medicinally important plants Cissus xavierensis, C. quadrangularis var. rotundus and C. vitiginea are analyzed and the phytoconstituents present are identified by GC-MS (Gas Chromatography-Mass Spectrometry) analysis. The analysis was carried out with the methanol extracts of the dried wild plant and callus of the three selected plants. The results concluded that the callus have more phytoconstituents than the wild plant extracts.


Ruby Nirmala L.,Holy Cross College Autonomous | Thomas Joseph Prakash J.,Hh The Rajahs College Autonomous
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

Potassium Chloride (KCl) as an additive is added into zinc thiourea chloride solution in a small amount (1 M%) by the method of slow evaporation solution growth technique at room temperature to get a new crystal. Due to the doping of the impurities on the crystals, remarkable changes in the physical properties were obtained. The grown crystals have been subjected to different instrumentation methods. The incorporation of the amount of potassium and zinc in the crystal lattices has been determined by AAS method. The lattice dimensions have been identified from single crystal X-ray diffraction measurements. The presence of functional group for the grown crystals has been identified by FTIR analysis. The optical, thermal and mechanical behaviors have been assessed by UV-Vis, TG/DTA and Vickers hardness methods respectively. The presence of dislocations of atoms has been identified by etching studies. © 2012 Elsevier B.V. All rights reserved.


Ruby Nirmala L.,Holy Cross College Autonomous | Thomas Joseph Prakash J.,Hh The Rajahs College
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2012

Single crystals of pure bis thiourea zinc acetate (BTZA) and lithium chloride (LiCl) doped BTZA have been synthesized and grown successfully from aqueous solutions by slow evaporation technique. The single crystals thus grown were characterized by different techniques such as single crystal XRD, AAS, FT-IR, UV-Vis, TG/DTA and SHG test. The single crystal XRD study proved that the dopant has not changed the structure of the parent crystal. The AAS study confirmed the presence of lithium in the doped crystal. The FTIR study ascertained the metal coordination of lithium chloride doped BTZA through thiourea. The optical behavior of the doped crystal has been examined by UV spectral analysis. Thermal studies TGA & DTA of the doped crystal have been investigated and found that the doped crystal is thermally more stable than the pure crystal. The SHG test using Nd: YAG Laser confirmed the NLO activity of the pure and doped crystal. The obtained results are presented and discussed. © 2012 Elsevier B.V. All rights reserved.


Vimala J.R.,Holy Cross College Autonomous | Raja S.,St. Joseph's College
Research Journal of Chemistry and Environment | Year: 2013

The inhibition of corrosion of mild steel using Vitex negundo extract in 1M HCl and DD water solutions was investigated by weight loss method at 30°C. The result showed that corrosion rate was significantly decreased in presence of the extract and inhibition efficiency increased with increasing the concentration of extract. In case of HCl maximum inhibition efficiency (86.39%) was noticed at 95 ppm inhibitor concentration and in DD water, it was found 92.86% efficiency at the same concentration of inhibitor. At lower concentration of inhibitor, better inhibition was observed in DD water medium as compared to HC. Polarization study reveals that this formulation controls the cathodic reaction predominantly. AC impedance spectra reveal that a protective film is formed on the metal surface. The decreased corrosion rate was due to adsorption of plant extract which was discussed on the basis of polarization and AC impedance measurements. Adsorption of Vitex negundo depends on its chemical composition which showed the presence of various compounds like flavonoids, steroids, tannins and phenolic compounds etc. which have oxygen atoms with lone pair electrons for co-ordinate bonding with metal.


Pitchai D.,Holy Cross College Autonomous | Manikkam R.,Holy Cross College Autonomous
Medicinal Chemistry Research | Year: 2012

A study of ancient literature indicates that diabetes was fairly well known and well conceived as an entity in India. The nature has provided abundant plant wealth for all the living creatures, which possess medicinal virtues. Therefore, there is a necessity to explore their uses and to conduct pharmacognostic and pharmacological studies to ascertain their therapeutic properties. In fact, nowadays diabetes is a global problem. Hence, this study aims to open new avenues for the improvement of medicinal uses of catechin isolated from the methanol extract of Cassia fistula stem bark for the selected area of diabetes. Oral administration of catechin (20 mg/kg b.wt) for 60 days produce a better glucose tolerance pattern in Streptozotocin-induced diabetic male albino Wistar rats. Another important objective of the study is to bring the implication of computer-aided drug development. In biomedical arena, computer-aided or in silico design is being utilized to expedite and facilitate hit identification, hit-tolead selection, optimize the absorption, distribution, metabolism, excretion and toxicity profile, and avoid safety issues. Commonly used computational approaches include ligand-based drug design (pharmacophore, a 3-D spatial arrangement of chemical features essential for biological activity), structure-based drug design (drug target docking), and quantitative structure-activity and quantitative structure-property relationships. The 3D structure of the catechin was docked with the receptors (PPARγ and insulin receptor) by Discovery Studio 2.1 version (An Accelery's product). The results show that catechin possesses a potential agonist characteristic that is capable of activating Insulin receptor and Peroxisome proliferator-activated receptor gamma. These results confirm the hypoglycemic effect of catechin. We can conclude that catechin could be developed into potential oral hypoglycemic drug. © Springer Science+Business Media, LLC 2011.


Sumathi P.,Holy Cross College Autonomous | Parvathi A.,Holy Cross College Autonomous
Journal of Medicinal Plants Research | Year: 2010

The present investigation is focused on antibacterial potential of dimethyl sulphoxide (DMSO) extracts from fruits of Emblica officinalis Gaertn., Terminalia bellerica Roxb. and Terminalia chebula Retz. against Salmonella typhi (32 strains) isolated from different human pathogens in agar dilution technique. DMSO fruit extracts of E. officinalis showed potent antimicrobial activity against S. typhi whereas T. bellerica was found to be highly effective against S. typhi. Crude fruit extract of T. chebula also showed significant antibacterial activity against 32 different strains of S.typhi. © 2010 Academic Journals.


Sumathi P.,Holy Cross College Autonomous | Parvathi A.,Holy Cross College Autonomous
Journal of Medicinal Plants Research | Year: 2010

The antimicrobial activity of the extracts of Andrographis paniculata Nees; Phyllanthus niruri Linn.; Terminalia bellerica Roxb.; Terminalia chebula Retz.; and Vitex negundo Linn., was studied against four gram negative and one gram positive bacteria. The results showed that the minimum inhibitory concentration (MIC) of P. niruri leaf extract was 50 μg/ml against Salmonella typhi and Staphylococcus aureus, where as, the MICs of T. bellerica fruit extract against Escherichia coli and S. aureus were 50 and 200 μg/ml respectively. However, the leaf extracts of the Andrographis paniculata, T. chebula and V. negundo have not shown any antimicrobial activity in the tested concentrations. © 2010 Academic Journals.


Shanthi P.,Holy Cross College Autonomous | Amudha P.,Holy Cross College Autonomous
International Journal of Pharma and Bio Sciences | Year: 2010

Acmella calva (DC.) R.K.Jansen., commonly known as toothache plant was analyzed for their chemical composition and minerals. The various extracts of the plant parts (leaves, inflorescence and whole plant) possessed the presence of active phytochemical constituents such as alkaloids, glycosides, flavanoids, reducing sugar, tannins, anthraquinone, saponins and cardiac glycosides. The amount of total soluble protein (0.78±0.09 mg/g) and the total free amino acids (14.95±1.00 mg/g) was remarkably high in the inflorescence. In the whole plant, the carbohydrates content was (6.66±0.35 mg/g) estimated in high quantity. The secondary plant products such as phenols (6.14±0.46 mg/g) and tannins (2.63±0.06 mg/g) were found maximum in the leaves. The herb is a good source of minerals. The maximum amount of nitrogen (0.24±0.15 mg/g) and phosphorus (0.06±0.07 mg/g) was obtained in the inflorescence and the iron (2.67±0.05 mg/g) content was recorded high in the leaves.


Rajalakshmi M.,Holy Cross College Autonomous | Anita R.,Holy Cross College Autonomous
Chemico-Biological Interactions | Year: 2016

The use of herbal supplements either as extracts or plant-derived individual molecules has significantly increased in the process of drug discovery and development for their potential efficacy or reduced risk in treating human disorders. Tinospora cordifolia (T. cordifolia) is a widely used herbal source to treat various human ailments, including diabetes mellitus. The present study was aimed on evaluating the antidiabetic property of a novel polysaccharide isolated from the methanolic extract of T. cordifolia stem. Bioassay guided fractionation was followed to isolate a compound from the methanol extract. The compound was administered orally at a dose of 20 mg/kg.b.wt for 60 days to control and STZ-induced diabetic male Wistar rats. It was found that plasma glucose was significantly (p < 0.05) reduced compared to normal. Oral administration of the compound significantly decreased HBA1c, triglycerides and total cholesterol and at the same time markedly increased hemoglobin, tissue glycogen and HDL cholesterol. Also the compounds restored the altered carbohydrate metabolizing enzymes, insulin, C-peptide, 14C-glucose oxidation levels to near normal. In addition, the histological studies revealed that there was regeneration of β-cells in the pancreatic sections. The expression of Glut-4 mRNA and protein in the gasrtocnemius muscle were significantly enhanced after the compound treatment. These results confirm that the novel polysaccharide possesses hypoglycemic, glucose oxidizing, hypolipidemic and β-cell regenerative properties and hence it could be developed into potential oral hypoglycemic drug with lesser side effects. © 2015 Elsevier Ireland Ltd. All rights reserved.

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