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Holon, Israel

Holon Institute of Technology , is an academic institution of higher learning in Holon, Israel. It focuses on teaching Science, Engineering, Applied Mathematics, Instructional Technologies, Design and Technology Management. HIT also deals with both theoretical and applied research and holds strong ties with the Israeli industry.HIT was the first college in Israel which was accredited to grant the B.Sc. degree . As other colleges receive accreditation, HIT became the first to be accredited to give the M.Sc. degree. Wikipedia.


Shenkman B.,National Hemophilia Center | Einav Y.,Holon Institute of Technology
Autoimmunity Reviews | Year: 2014

Thrombotic microangiopathies (TMAs) include several diseases, most prominently are thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS). TMAs are characterized by profound thrombocytopenia, microangiopathic hemolytic anemia and organ ischemia. In most cases TTP results from deficiency of ADAMTS13, the von Willebrand factor-cleaving protease leading to increase of ultra-large von Willebrand factor (ULVWF) multimers. Congenital TTP is due to mutations in the gene of ADAMTS13 whereas acquired TTP is due to production of autoantibodies against ADAMTS13. In both cases severe deficiency of ADAMTS13 exists. However, the presence of ADAMTS13 activity does not rule out TTP. Diagnostic criteria of TTP are based on clinical features of neurologic and renal disfunction along with anemia and thrombocytopenia, low ADAMTS13 activity, and the presence of ULVWF. The standard treatment of TTP includes plasma exchange, protein A immunoabsobtion, immunosuppressive drugs, CD20 antibodies against B cells, and splenectomy. HUS is commonly caused by infection with Shiga-toxin produced by Escherichia coli. HUS is characterized by thrombocytopenia, anemia, renal impairment and diarrhea. Rarely, atypical HUS appears as a consequence of mutations related to the alternative pathway for the compliment system. Plasmapheresis in HUS is not efficient. Alternatively, plasma therapy and in some cases dialysis are used. TMA diseases may be associated with other infections, bone marrow transplantation, pregnancy, systemic vasculitis, and certain drugs. © 2014 Elsevier B.V. Source


Eliazar I.,Holon Institute of Technology | Klafter J.,Tel Aviv University
Annals of Physics | Year: 2011

Brownian motion is widely considered the quintessential model of diffusion processes-the most elemental random transport processes in Science and Engineering. Yet so, examples of diffusion processes displaying highly non-Brownian statistics-commonly termed "Anomalous Diffusion" processes-are omnipresent both in the natural sciences and in engineered systems. The scientific interest in Anomalous Diffusion and its applications is growing exponentially in the recent years. In this Paper we review the key statistics of Anomalous Diffusion processes: sub-diffusion and super-diffusion, long-range dependence and the Joseph effect, Lévy statistics and the Noah effect, and 1/f noise. We further present a theoretical model-generalizing the Einstein-Smoluchowski diffusion model-which provides a unified explanation for the prevalence of Anomalous Diffusion statistics. Our model shows that what is commonly perceived as "anomalous" is in effect ubiquitous. © 2011 Elsevier Inc. Source


Eliazar I.,Holon Institute of Technology
European Physical Journal: Special Topics | Year: 2013

In this paper we demonstrate the remarkable effectiveness of Poissonian randomizations in the generation of statistical universality. We do so via a highly versatile spatio-statistical model in which points are randomly scattered, according to a Poisson process, across a general metric space. The points have general independent and identically distributed random physical characteristics. A probe is positioned in space, and is affected by the points. The effect of a given point on the probe is a function of the physical characteristic of the point and the distance of the point from the probe. We determine the classes of Poissonian randomizations-i. e., the spatial Poissonian scatterings of the points-that render the effects of the points invariant with respect to the physical characteristics of the points. These Poissonian randomizations have intrinsic power-law structures, yield statistical robustness, and generate universal statistics including Lévy distributions and extreme-value distributions. In effect, our results establish how "fractal" spatial geometries lead to statistical universality. © 2013 EDP Sciences and Springer. Source


Eliazar I.,Holon Institute of Technology
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | Year: 2012

Weibull's distribution is the principal phenomenological law of relaxation in the physical sciences and spans three different relaxation regimes: subexponential ("stretched exponential"), exponential, and superexponential. The probabilistic theory of extreme-value statistics asserts that the linear scaling limits of minima of ensembles of positive-valued random variables, which are independent and identically distributed, are universally governed by Weibull's distribution. However, this probabilistic theory does not take into account spatial geometry, which often plays a key role in the physical sciences. In this paper we present a general and versatile model of random reactions in random environments and establish a geometry-based theory for the universal emergence of Weibull's distribution. © 2012 American Physical Society. Source


Eliazar I.,Holon Institute of Technology | Klafter J.,Tel Aviv University
Physics Reports | Year: 2012

We establish a path leading from Pareto's law to anomalous diffusion, and present along the way a panoramic overview of power-law statistics. Pareto's law is shown to universally emerge from "Central Limit Theorems" for rank distributions and exceedances, and is further shown to be a finite-dimensional projection of an infinite-dimensional underlying object - Pareto's Poisson process. The fundamental importance and centrality of Pareto's Poisson process is described, and we demonstrate how this process universally generates an array of anomalous diffusion statistics characterized by intrinsic power-law structures: sub-diffusion and super-diffusion, Lévy laws and the "Noah effect", long-range dependence and the "Joseph effect", 1 / f noises, and anomalous relaxation. © 2011 Elsevier B.V. Source

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