Holon, Israel

Holon Institute of Technology , is an academic institution of higher learning in Holon, Israel. It focuses on teaching Science, Engineering, Applied Mathematics, Instructional Technologies, Design and Technology Management. HIT also deals with both theoretical and applied research and holds strong ties with the Israeli industry.HIT was the first college in Israel which was accredited to grant the B.Sc. degree . As other colleges receive accreditation, HIT became the first to be accredited to give the M.Sc. degree. Wikipedia.


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Shenkman B.,National Hemophilia Center | Einav Y.,Holon Institute of Technology
Autoimmunity Reviews | Year: 2014

Thrombotic microangiopathies (TMAs) include several diseases, most prominently are thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS). TMAs are characterized by profound thrombocytopenia, microangiopathic hemolytic anemia and organ ischemia. In most cases TTP results from deficiency of ADAMTS13, the von Willebrand factor-cleaving protease leading to increase of ultra-large von Willebrand factor (ULVWF) multimers. Congenital TTP is due to mutations in the gene of ADAMTS13 whereas acquired TTP is due to production of autoantibodies against ADAMTS13. In both cases severe deficiency of ADAMTS13 exists. However, the presence of ADAMTS13 activity does not rule out TTP. Diagnostic criteria of TTP are based on clinical features of neurologic and renal disfunction along with anemia and thrombocytopenia, low ADAMTS13 activity, and the presence of ULVWF. The standard treatment of TTP includes plasma exchange, protein A immunoabsobtion, immunosuppressive drugs, CD20 antibodies against B cells, and splenectomy. HUS is commonly caused by infection with Shiga-toxin produced by Escherichia coli. HUS is characterized by thrombocytopenia, anemia, renal impairment and diarrhea. Rarely, atypical HUS appears as a consequence of mutations related to the alternative pathway for the compliment system. Plasmapheresis in HUS is not efficient. Alternatively, plasma therapy and in some cases dialysis are used. TMA diseases may be associated with other infections, bone marrow transplantation, pregnancy, systemic vasculitis, and certain drugs. © 2014 Elsevier B.V.


Vidal P.,Holon Institute of Technology | Kanzieper E.,Holon Institute of Technology
Physical Review Letters | Year: 2012

The scattering matrix approach is employed to determine a joint probability density function of reflection eigenvalues for chaotic cavities coupled to the outside world through both ballistic and tunnel point contacts. Derived under assumption of broken time-reversal symmetry, this result is further utilized to (i)calculate the density and correlation functions of reflection eigenvalues, and (ii)analyze fluctuations properties of the Landauer conductance for the illustrative example of asymmetric chaotic cavity. Further extensions of the theory are pinpointed. © 2012 American Physical Society.


Fruchtman A.,Holon Institute of Technology
IEEE Transactions on Plasma Science | Year: 2011

The thrust provided by a plasma source, open at one end, is calculated for an arbitrary ratio of collision to ionization rates. If the plasma is of a low collisionality, ion pumping is dominant, and the momentum of the jet exiting the source is carried mostly by the plasma. In the collisional regime, neutrals are accelerated through charge-exchange collisions with ions, leading to neutral pumping, so that most of the momentum of the jet is carried by the neutral gas. It is shown that these ion-neutral collisions increase the thrust for a given power. However, the conventionally defined efficiency for a thruster, reflecting also the propellant utilization, is lower in the collisional regime. © 2010 IEEE.


Eliazar I.,Holon Institute of Technology
European Physical Journal: Special Topics | Year: 2013

In this paper we demonstrate the remarkable effectiveness of Poissonian randomizations in the generation of statistical universality. We do so via a highly versatile spatio-statistical model in which points are randomly scattered, according to a Poisson process, across a general metric space. The points have general independent and identically distributed random physical characteristics. A probe is positioned in space, and is affected by the points. The effect of a given point on the probe is a function of the physical characteristic of the point and the distance of the point from the probe. We determine the classes of Poissonian randomizations-i. e., the spatial Poissonian scatterings of the points-that render the effects of the points invariant with respect to the physical characteristics of the points. These Poissonian randomizations have intrinsic power-law structures, yield statistical robustness, and generate universal statistics including Lévy distributions and extreme-value distributions. In effect, our results establish how "fractal" spatial geometries lead to statistical universality. © 2013 EDP Sciences and Springer.


Eliazar I.,Holon Institute of Technology | Klafter J.,Tel Aviv University
Physics Reports | Year: 2012

We establish a path leading from Pareto's law to anomalous diffusion, and present along the way a panoramic overview of power-law statistics. Pareto's law is shown to universally emerge from "Central Limit Theorems" for rank distributions and exceedances, and is further shown to be a finite-dimensional projection of an infinite-dimensional underlying object - Pareto's Poisson process. The fundamental importance and centrality of Pareto's Poisson process is described, and we demonstrate how this process universally generates an array of anomalous diffusion statistics characterized by intrinsic power-law structures: sub-diffusion and super-diffusion, Lévy laws and the "Noah effect", long-range dependence and the "Joseph effect", 1 / f noises, and anomalous relaxation. © 2011 Elsevier B.V.


Eliazar I.,Holon Institute of Technology
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | Year: 2012

Weibull's distribution is the principal phenomenological law of relaxation in the physical sciences and spans three different relaxation regimes: subexponential ("stretched exponential"), exponential, and superexponential. The probabilistic theory of extreme-value statistics asserts that the linear scaling limits of minima of ensembles of positive-valued random variables, which are independent and identically distributed, are universally governed by Weibull's distribution. However, this probabilistic theory does not take into account spatial geometry, which often plays a key role in the physical sciences. In this paper we present a general and versatile model of random reactions in random environments and establish a geometry-based theory for the universal emergence of Weibull's distribution. © 2012 American Physical Society.


Eliazar I.I.,Holon Institute of Technology | Shlesinger M.F.,U.S. Navy
Physics Reports | Year: 2013

Brownian motion is the archetypal model for random transport processes in science and engineering. Brownian motion displays neither wild fluctuations (the "Noah effect"), nor long-range correlations (the "Joseph effect"). The quintessential model for processes displaying the Noah effect is Lévy motion, the quintessential model for processes displaying the Joseph effect is fractional Brownian motion, and the prototypical model for processes displaying both the Noah and Joseph effects is fractional Lévy motion. In this paper we review these four random-motion models-henceforth termed "fractional motions"-via a unified physical setting that is based on Langevin's equation, the Einstein-Smoluchowski paradigm, and stochastic scaling limits. The unified setting explains the universal macroscopic emergence of fractional motions, and predicts-according to microscopic-level details-which of the four fractional motions will emerge on the macroscopic level. The statistical properties of fractional motions are classified and parametrized by two exponents-a "Noah exponent"governing their fluctuations, and a "Joseph exponent"governing their dispersions and correlations. This self-contained review provides a concise and cohesive introduction to fractional motions. © 2013 Elsevier B.V.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.8.1 | Award Amount: 3.67M | Year: 2012

The objective of INTUITEL is to enhance state-of-the-art e-learning content and Learning Management Systems (LMS) with features that so far have been provided only by human tutors. An INTUITEL-enabled system constitutes an integrated learning environment that configures itself in response to any learner, monitors his/her progress and behaviour, combines these data with pedagogical and methodological knowledge and then by automated reasoning deduces optimal guidance and feedback. The deductive process may include the current learner performance, the daily learning attitude and emotional setting of the learner, personal aspects like gender, culture and age as well as environmental aspects like available communication bandwidth, ambient noise level, screen size and type of access device. INTUITEL therefore will be a step towards a global learning cloud, where personalized technology-enhanced learning is available for any person at any place, with any access device and under any external condition, including mobile learning scenarios. In INTUITEL, learning goals will be defined according to the desired competency, which will be mapped to the available content. At the same time, high flexibility to choose a learning pathway is maintained by offering system driven and learner directed navigation tools, thereby increasing the empowerment of teachers and learners and fostering the acquisition of methodological knowledge. By interpreting the learners responses INTUITEL will automatically determine his/her position in a cognitive model for the particular learning content. The INTUITEL-enabled LMS then plays the role of a pedagogically skilled teacher, transparently guiding the learner towards the required competencies. Particular emphasis will be put on a widespread dissemination of INTUITEL results across the e-learning industry as well as in schools, universities and to other educational key players in collaboration with a major e-learning conference.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2010-IRSES | Award Amount: 412.30K | Year: 2011

The goal of the DCP-PhysBio exchange program is to bring together several European teams (France, Germany, UK), Israel, as well as partners from Russia and Ukraine. We want to use our combined expertise to study various challenging dynamical and cooperative phenomena taking place in complex physical and biological systems. All the teams have a track record of research in these areas concentrating on particular numerical or theoretical facets, such that the network will synergistically amplify their strengths. The staff exchanges will include both a team research work on specific work packages which will further consolidate the research partnership, and a transfer of knowledge component of workshops, schools and seminars which will ensure an effective dissemination of results and foster interactions amongst the young researchers. If the aims of our proposal are to be achieved, then not only that a long-term research network will emerge but a number of PhD students and early career researchers will have had been mentored into, and intensively exposed to, a culture of international collaborative research.


Eliazar I.,Holon Institute of Technology
Physica A: Statistical Mechanics and its Applications | Year: 2011

We consider an evolving ensemble assembled from a set of n different elements via a stochastic growth process in which independent and identically distributed copies of the elements arrive randomly in time, and their statistics are governed by Zipf's law. The associated "Heaps process" is the stochastic process tracking the fraction of different element copies present in the evolving ensemble at any given time point. For example, the evolving ensemble is a text assembled from a stream of words, and the Heaps process keeps count of the number of different words in the evolving text. A detailed asymptotic statistical analysis of the Heaps process, in the limit n→∞, is conducted. This paper establishes a comprehensive "Heapsian analysis" of the growth statistics of Zipfian ensembles. The analysis presented far extends and generalizes Heaps' law, which asserts that the number of different words in a text of length l follows a power law in the variable l. © 2011 Elsevier B.V. All rights reserved.

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