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PubMed | Holistic Education Center, National Chiao Tung University, St. Mary's College, Mackay Medical College and Tzu Chi University
Type: | Journal: European journal of pharmacology | Year: 2016

This study evaluated the effects of acetylsalicylic acid (ASA) on exercise-induced inflammatory response, muscle damage, and liver injury in rats. Wistar-Kyoto (WKY) rats were divided into six groups: control (C), exercise (E), C+20mg ASA, E+20mg ASA, C+100mg/kg ASA, and E+100mg ASA groups. ASA or a vehicle was orally administered through gavage 1h before a treadmill test. Upon trial completion, blood was drawn at 1, 12, and 24h for biochemical analysis, and livers were excised at 24h for a histological assessment. Our results revealed that 100mg/kg ASA significantly reduced interleukin (IL)-6 and tumor necrosis factor (TNF)- levels in the E groups; however, the IL-10 level was considerably increased. Moreover, aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels and histological hepatic damage increased significantly in the E+100mg ASA group compared with the corresponding changes in the E group. These results suggest that the prophylactic administration of particularly high-dose ASA alleviates exercise-induced inflammatory response but exacerbates liver injury.


PubMed | National Taiwan Ocean University, Chang Gung University, Chang Gung Memorial Hospital, Holistic Education Center and 2 more.
Type: Journal Article | Journal: Marine drugs | Year: 2015

Fucoidan, a heparin-like sulfated polysaccharide, is rich in brown algae. It has a wide assortment of protective activities against cancer, for example, induction of hepatocellular carcinoma senescence, induction of human breast and colon carcinoma apoptosis, and impediment of lung cancer cells migration and invasion. However, the anti-metastatic mechanism that fucoidan exploits remains elusive. In this report, we explored the effects of fucoidan on cachectic symptoms, tumor development, lung carcinoma cell spreading and proliferation, as well as expression of metastasis-associated proteins in the Lewis lung carcinoma (LLC) cells-inoculated mice model. We discovered that administration of fucoidan has prophylactic effects on mitigation of cachectic body weight loss and improvement of lung masses in tumor-inoculated mice. These desired effects are attributed to inhibition of LLC spreading and proliferation in lung tissues. Fucoidan also down-regulates expression of matrix metalloproteinases (MMPs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and vascular endothelial growth factor (VEGF). Moreover, the tumor-bearing mice supplemented with fucoidan indeed benefit from an ensemble of the chemo-phylacticity. The fact is that fucoidan significantly decreases viability, migration, invasion, and MMPs activities of LLC cells. In summary, fucoidan is suitable to act as a chemo-preventative agent for minimizing cachectic symptoms as well as inhibiting lung carcinoma metastasis through down-regulating metastatic factors VEGF and MMPs.


Ma C.-M.,St. Mary's College | Hong G.-B.,St. Mary's College | Chen H.-W.,St. Mary's College | Hang N.-T.,Da - Yeh University | Shen Y.-S.,Holistic Education Center
International Journal of Photoenergy | Year: 2011

The effects of pH value, VUV intensity, initial dye concentration, initial H 2O 2 concentration, and TiO 2 loading dose on the degradation of three azo dyes: acid Orange 8, acid Blue 29, and acid Blue 113 were studied to explore and compare the treatment efficiencies among the adopted AOPs. It was found that pH played an important role in the degradation of dyes using VUV irradiation. For VUV/H 2O 2, VUV/TiO 2, and VUV/TiO 2/H 2O 2 processes, the decoloration rates of the three azo dyes were more efficient under acidic conditions relative to alkaline conditions. The degradation rates of dyes increased with increasing concentrations of H 2O 2, but reaction rates were retarded at high concentrations of H 2O 2 because the H 2O 2 compound acted as a scavenger of the hydroxyl radical. In this paper, three azo dyes were decomposed efficiently by VUV irradiation only demonstrating the effectiveness of VUV direct photolysis. Copyright © 2011 Chih-Ming Ma et al.


Shen Y.-S.,Holistic Education Center | Ma C.-M.,St. Mary's College | Hong G.-B.,St. Mary's College | Peng J.-Y.,Kainan University | Lin J.-H.,Holistic Education Center
Journal of the Chinese Institute of Engineers, Transactions of the Chinese Institute of Engineers,Series A/Chung-kuo Kung Ch'eng Hsuch K'an | Year: 2011

The decomposition of phenolic compounds (phenol, p-chlorophenol, and p-nitrophenol) in wastewaters by VUV direct photolysis and VUV/H 2O 2 process with a 185nm Vacuum-UV lamp in a batch photoreactor was studied under various solution pH values and purging gases (N 2 and O 2). The photolytic properties of these phenolic compounds were found to be highly dependent on the solution pH. Experimental results for the VUV alone system revealed that photolytic rates of organics by purging O 2 were apparently larger than those by purging N 2 and the removal of organics was found to be above 95%. For the 185 nm/VUV/H 2O 2 process, the reaction rates were significantly raised compared to those by direct photolysis. © 2011 The Chinese Institute of Engineers.


PubMed | Chang Gung University, National Taiwan University, Holistic Education Center and Taipei Medical University Hospital
Type: Journal Article | Journal: Journal of the Formosan Medical Association = Taiwan yi zhi | Year: 2016

Few studies have investigated the feasibility of using pudendal neuromodulation to regulate bladder function in spinal cord-injured (SCI) animals. The present study aimed to determine the effects of electrical activation of the pudendal sensory branch on improving voiding functions in rats 6 weeks after a spinal cord injury and to explore the underlying neuromodulatory mechanisms.Two urodynamic measurements were used to assess the effects of electrical stimulation (ES) on bladder and urethral functions: simultaneous recordings of the intravesical pressure (IVP) during continuous isotonic transvesical infusion (i.e., isotonic IVP) and external urethral sphincter (EUS) electromyography (EUS-EMG), and simultaneous recordings of transvesical pressure under isovolumetric conditions (i.e., isovolumetric IVP) and urethral perfusion pressure (UPP).Six weeks after the SCI, the rats showed voiding dysfunction, as indicated by abnormal cystometric measurements (e.g., increased volume threshold, increased contraction amplitude, and increased residual volume, and decreased voided volume). The voiding efficiency (VE) decreased to 13% after the SCI, but increased to 22-34% after applying pudendal afferent stimulation. In addition, pudendal stimulation significantly increased the EUS burst period and increased the difference between the UPP and the high-frequency oscillation (HFO) baselines, and changed the time offset between bladder and EUS activities. These findings suggest that pudendal afferent stimulation improved the VE by prolonging the micturition interval, decreased the urethral resistance, and recovered detrusor-sphincter dyssynergia during the voiding phase.This study demonstrates the feasibility of using pudendal neuromodulation in chronic SCI rats. These results could aid in developing an advanced neural prosthesis to restore bladder function in clinical settings.


Lin Y.-J.,Holistic Education Center | Lin Y.-J.,National Yang Ming University | Lin C.Y.,National Taipei University of Nursing and Health Sciences | Li Y.-C.,National Taipei University of Nursing and Health Sciences
Death Studies | Year: 2014

In 2008, the Taiwan Association for Care and Counseling for Loss organized a workshop about Horticultural Therapy, conducted as a participatory action research (PAR). Nineteen grief caregivers participated. Specific goals were designed according to a survey of participant expectations and focus-group discussions. The workshop content included lectures and interactive activities. Results demonstrated that most participants displayed an increased awareness of personal loss and meaning in grief, indicating that horticulture and nature appreciation might relieve individual grief and stress. The report introduces the rationale, evolution, execution, and results of the program development. © 2014 Taylor & Francis Group, LLC.


Wang S.-W.,Mackay Medical College | Wu H.-H.,Tainan Municipal Hospital | Liu S.-C.,Mackay Memorial Hospital | Wang P.-C.,Mackay Memorial Hospital | And 4 more authors.
PLoS ONE | Year: 2012

Background: Osteosarcoma is characterized by a high malignant and metastatic potential. CCL5 (previously called RANTES) was originally recognized as a product of activated T cells, and plays a crucial role in the migration and metastasis of human cancer cells. It has been reported that the effect of CCL5 is mediated via CCR receptors. However, the effect of CCL5 on migration activity and integrin expression in human osteosarcoma cells is mostly unknown. Methodology/Principal Findings: Here we found that CCL5 increased the migration and expression of αvβ3 integrin in human osteosarcoma cells. Stimulation of cells with CCL5 increased CCR5 but not CCR1 and CCR3 expression. CCR5 mAb, inhibitor, and siRNA reduced the CCL5-enhanced the migration and integrin up-regulation of osteosarcoma cells. Activations of MEK, ERK, and NF-κB pathways after CCL5 treatment were demonstrated, and CCL5-induced expression of integrin and migration activity was inhibited by the specific inhibitor and mutant of MEK, ERK, and NF-κB cascades. In addition, over-expression of CCL5 shRNA inhibited the migratory ability and integrin expression in osteosarcoma cells. Conclusions/Significance: CCL5 and CCR5 interaction acts through MEK, ERK, which in turn activates NF-κB, resulting in the activations of αvβ3 integrin and contributing the migration of human osteosarcoma cells. © 2012 Wang et al.


Liu K.F.-R.,Ming Chi University of Technology | Chen C.-W.,National Kaohsiung Marine University | Shen Y.-S.,Holistic Education Center
International Journal of Environmental Science and Technology | Year: 2013

The sanitary sewerage connection rate is an important indicator of advanced cities. Following the construction of sanitary sewerages, the maintenance and management systems are required for keeping pipelines and facilities functioning well. These maintenance tasks often require sewer workers to enter the manholes and the pipelines, which are confined spaces short of natural ventilation and have the potential for hazardous substances to be present. Working in sewers could be easily exposed to a risk of adverse health effects. This paper proposes the use of Bayesian belief networks as a higher level of noncarcinogenic health risk assessment of sewer workers. On the basis of the epidemiological studies, the actual hospital attendance records and expert experiences, the Bayesian belief networks is capable of capturing the probabilistic relationships between the hazardous substances in sewers and their adverse health effects, and accordingly inferring the morbidity and mortality of the adverse health effects. The provision of the morbidity and mortality rates of the related diseases is more informative and can alleviate the drawbacks of conventional methods. © 2012 CEERS, IAU.


Liu K.F.R.,Ming Chi University of Technology | Liang H.H.,National United University | Chen C.W.,National Kaohsiung Marine University | Chen J.S.,Ming Chi University of Technology | Shen Y.S.,Holistic Education Center
Journal of Environmental Informatics | Year: 2012

The purpose of determining impact significance is to place value on impacts. Environmental impact assessment review is a process that judges whether impact significance is acceptable or not in accordance with the scientific facts regarding environmental, ecological and socio-economical impacts described in environmental impact statements or environmental impact assessment reports. The first aim of this paper is to summarize the criteria of significance evaluation from the past review results and accordingly utilize fuzzy rule-based system to incorporate these criteria into scientific facts. The second aim is to employ data mining technique to construct an environmental impact statement or environmental impact assessment report prediction model for reviewing results which can assist developers to prepare and revise better environmental management plans in advance. The validity of the previous prediction model proposed by authors in 2009 is 92.7%. The enhanced validity in this study can attain 100.0% after taking significance criteria into account. In the case study, some indicators are over-standard in first and second-order significance but all indicators ultimately fall into the category of conditional approval in third-order significance. © 2012 ISEIS All rights reserved.


Wang S.-P.,Holistic Education Center | Lin S.-W.,Tamkang University | Chyan C.-J.,Tamkang University
Mathematical and Computer Modelling | Year: 2011

This work gives a criterion for the existence of positive solutions for nonlinear second order ordinary differential equations with two-point boundary conditions on time scales. Moreover, for some source terms which are in the sense of sublinear or superlinear, we also formulate corollaries and examples for applications and we improve previous results related with the first eigenvalue discussed by Professor Li. © 2010 Elsevier Ltd.

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