Ebetsu, Japan
Ebetsu, Japan

Hokusho University is a private university in Ebetsu, Hokkaido, Japan. The predecessor of the school was founded in 1939 under the name Hokkaido Women's College. It was chartered as a junior women's college in 1963. It became a four-year college in 1997. The present name was adopted in 2007. Wikipedia.


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Yoshida M.,Hokusho University | Saho Y.,Sapporo Medical University | Katayose M.,Sapporo Medical University
Journal of Sport Rehabilitation | Year: 2010

Context: Studies have reported the difference in humeral retroversion (HR) between the dominant and nondominant side in throwing athletes. However, there are few data concerning HR for the rest of the population. In addition, the relationship between HR and external (ER) and internal rotation (IR) at 90° shoulder abduction has not been thoroughly investigated. Objectives: To investigate the reliability of ultrasound methodology to measure HR. In addition, using ultrasonography, the authors compare HR between the dominant and nondominant sides in healthy adult men and determine the relationship between HR and ER and IR at 90° of shoulder abduction. Design: Descriptive study. Setting: Laboratory. Participants: Thirty-seven healthy male subjects (age 21.9 ± 2.4 y, height 172.9 ± 5.3 cm, weight 66.0 ± 7.2 kg) with no history of shoulder or elbow injury, recruited from a convenience sample, volunteered for the study. Main Outcome Measures: Subjects were bilaterally examined for HR, ER, and IR. HR was measured by ultrasonography. Results: The intrarater reliability of the ultrasound methodology was .91-.98, and the interrater reliability was .97. The HR angle on the dominant side (mean ± SD: 68.5° ± 10.0°) was significantly greater than that of the nondominant side (58.0° ± 8.4°; P < .001). ER on the dominant side was significantly greater than on the nondominant side (P < .001), whereas IR on the dominant side was significantly smaller than on the nondominant side (P < .001). Total arc of motion for the dominant side was not significantly different from that of the nondominant side (P = .335). Conclusion: In the current study, ultrasound methodology to measure HR showed high interrater reliability, as well as high intrarater reliability. In addition, this study indicates that healthy Japanese adult men have side-to-side differences in HR. © 2010 Human Kinetics, Inc.


Oda S.,Hokusho University | Shirakawa K.,Hokusho University
European Journal of Applied Physiology | Year: 2014

Purpose Many studies have failed to show that pre-sleep exercise has a negative effect on sleep onset. However, since only a moderate level of physiological excitement was observed at bedtime in these studies, it remains unclear whether a larger magnitude of physiologic excitement present at bedtime would disrupt sleep onset. This study compared the effects of pre-sleep exercise, which led to different levels of physiologic excitement at bedtime (moderate and heavy), on sleep onset. Methods Twelve active young men underwent non-exercise, moderate-intensity exercise, and high-intensity exercise conditions. The subjects maintained a sedentary condition on a reclining seat throughout the day. On the non-exercise day, the subjects remained seated at rest until going to bed. On the moderate- and high-intensity exercise days, the subject exercised for 40 min (21:20-22:00) at 60 and 80 % heart rate reserve, respectively. Sleep polysomnography, core body and skin temperatures, heart rate (HR), and heart rate variability (HRV) were recorded. Results We observed a delay in sleep onset (+14.0 min, P < 0.05), a marked physiological excitement at bedtime as reflected by an increased HR (+25.7 bpm, P < 0.01), and a lower high-frequency power of HRV (-590 ms2, P < 0.01) only on the high-intensity exercise day. Conclusions These results indicate that pre-sleep vigorous exercise, which causes a large physiologic excitement at bedtime, might disrupt the onset of sleep. © 2014 Springer-Verlag Berlin Heidelberg.


Inoue N.,Hokkaido University | Kinugawa S.,Hokkaido University | Suga T.,Hokkaido University | Yokota T.,Hokkaido University | And 4 more authors.
American Journal of Physiology - Heart and Circulatory Physiology | Year: 2012

Angiotensin II (ANG II)-induced oxidative stress has been known to be involved in the pathogenesis of cardiovascular diseases. We have reported that the oxidative stress in skeletal muscle can limit exercise capacity in mice (16). We thus hypothesized that ANG II could impair the skeletal muscle energy metabolism and limit exercise capacity via enhancing oxidative stress. ANG II (50 ng·kg -1·min -1) or vehicle was infused into male C57BL/6J mice for 7 days via subcutaneously implanted osmotic minipumps. ANG II did not alter body weight, skeletal muscle weight, blood pressure, cardiac structure, or function. Mice were treadmill tested, and expired gases were analyzed. The work to exhaustion (vertical distance × body weight) and peak oxygen uptake were significantly decreased in ANG II compared with vehicle. In mitochondria isolated from skeletal muscle, ADP-dependent respiration was comparable between ANG II and vehicle, but ADP-independent respiration was significantly increased in ANG II. Furthermore, complex I and III activities were decreased in ANG II. NAD(P)H oxidase activity and superoxide production by lucigenin chemiluminescence were significantly increased in skeletal muscle from ANG II mice. Treatment of ANG II mice with apocynin (10 mmol/l in drinking water), an inhibitor of NAD(P)H oxidase activation, completely inhibited NAD(P)H oxidase activity and improved exercise capacity, mitochondrial respiration, and complex activities in skeletal muscle. ANG II-induced oxidative stress can impair mitochondrial respiration in skeletal muscle and limit exercise capacity. © 2012 the American Physiological Society.


Kinugawa S.,Hokkaido University | Takada S.,Hokkaido University | Matsushima S.,Hokkaido University | Okita K.,Hokusho University | Tsutsui H.,Hokkaido University
International Heart Journal | Year: 2015

Exercise capacity is lowered in patients with heart failure, which limits their daily activities and also reduces their quality of life. Furthermore, lowered exercise capacity has been well demonstrated to be closely related to the severity and prognosis of heart failure. Skeletal muscle abnormalities including abnormal energy metabolism, transition of myofibers from type I to type II, mitochondrial dysfunction, reduction in muscular strength, and muscle atrophy have been shown to play a central role in lowered exercise capacity. The skeletal muscle abnormalities can be classified into the following main types: 1) low endurance due to mitochondrial dysfunction; and 2) low muscle mass and muscle strength due to imbalance of protein synthesis and degradation. The molecular mechanisms of these skeletal muscle abnormalities have been studied mainly using animal models. The current review including our recent study will focus upon the skeletal muscle abnormalities in heart failure. © 2015, International Heart Journal Association. All rights reserved.


Yokota T.,Hokkaido University | Yokota T.,Copenhagen University | Kinugawa S.,Hokkaido University | Yamato M.,Fukuoka University | And 11 more authors.
Diabetes Care | Year: 2013

OBJECTIVE-Systemic oxidative stress is associated with insulin resistance and obesity. We tested the hypothesis that systemic oxidative stress is linked to lower aerobic capacity and skeletal muscle dysfunction in metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS-The incremental exercise testing with cycle ergometer was performed in 14 male patients with MetS and 13 age-, sex-, and activity-matched healthy subjects. Systemic lipid peroxidation was assessed by serum thiobarbituric acid reactive substances (TBARS), and systemic antioxidant defense capacity was assessed by serum total thiols and enzymatic activity of superoxide dismutase (SOD). To assess skeletal muscle energy metabolism, we measured high-energy phosphates in the calf muscle during plantar flexion exercise and intramyocellular lipid (IMCL) in the resting leg muscle, using 31P- and 1protonmagnetic resonance spectroscopy, respectively. RESULTS-Serum TBARS were elevated (12.4 ± 7.1 vs. 3.7 ± 1.1 μmol/L; P < 0.01), and serum total thiols and SOD activity were decreased (290.8 ± 51.2 vs. 398.7 ± 105.2 μmol/L, P < 0.01; and 22.2 ± 8.4 vs. 31.5 ± 8.5 units/L, P < 0.05, respectively) in patients with MetS compared with healthy subjects. Peak VO2 and anaerobic threshold normalized to body weight were significantly lower in MetS patients by 25 and 31%, respectively, and inversely correlated with serum TBARS (r = 20.49 and r = 20.50, respectively). Moreover, muscle phosphocreatine loss during exercise was 1.4-fold greater in patients with MetS (P,0.05), and IMCL content was 2.9-fold higher in patients with MetS (P < 0.01), indicating impaired skeletal muscle energy metabolism, and these indices positively correlated with serum TBARS (r = 0.45 and r = 0.63, respectively). CONCLUSIONS-Systemic oxidative stress was associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients with MetS. © 2013 by the American Diabetes Association.


Morita N.,Hokkaido University of Education | Okita K.,Hokusho University | Okita K.,Sapporo Health Sports Foundation
Circulation Journal | Year: 2013

Background: This study compared older men and women with cardiovascular (CV) risk factors in terms of the effects of a 6-month exercise intervention on high-sensitivity C-reactive protein (hsCRP) levels, blood pressure (BP) and other risk factors. Methods and Results: Sixty older (age 61-79) overweight men and 71 such women with 2 or more risk factors (ie, systolic BP 130-179 mmHg, non-fasting blood glucose 110-139 mg/dl, and low-density lipoprotein cholesterol 120-219 mg/dl) participated in a 6-month exercise intervention. The exercise program consisted of moderate-intensity bicycle exercise for ~40 min, performed on average 2.5 times per week. Systolic and diastolic BP reductions were found to be greater in women than in men (SBP, -10.6 vs. -5.5 mmHg; DBP, -6.2 vs. -3.3 mmHg; both P<0.05). Decreases in body mass index were larger in women than in men (P<0.05). There was no significant gender difference in the changes in blood glucose and lipid profiles and hsCRP levels. After adjustment for confounders (exercise frequency, weight loss, age, and baseline values), there were still significant gender differences in the SBP and DBP reductions. hsCRP reduction were similar in both genders even after adjusting for weight loss. Conclusions: There could be gender differences in the beneficial effects of exercise training on the potent CV risk factors of BP and body weight, but not on hsCRP.


Yoshida M.,Hokusho University | Taniguchi K.,Sapporo Medical University | Katayose M.,Sapporo Medical University
Journal of Strength and Conditioning Research | Year: 2011

Yoshida, M, Taniguchi, K, and Katayose, M. Analysis of muscle activity and ankle joint movement during the side-hop test. J Strength Cond Res 25(8): 2255-2264, 2011-Functional performance tests (FPTs) that consist of movements, such as hopping, landing, and cutting, provide useful measurements. Although some tests have been established for kinematic studies of the knee joint, very few tests have been established for the ankle joint. To use the FPT as a test battery for patients with an ankle sprain, it is necessary to document typical patterns of muscle activation and range of motion (ROM) of the ankle joint during FPTs. Therefore, the purpose of this study was to investigate the pattern of the ROM of the ankle inversion/ eversion and the muscle activity of the peroneus longus muscle (PL) and the tibial anterior muscle (TA) in normal subjects during the side-hop test. To emphasize the characteristics of ROM and electromyography (EMG) at each phase, the sidehop tests were divided into 4 phases: lateral-hop contact phase (LC), lateral-hop flight phase (LF), medial hop contact phase (MC), and medial hop flight phase (MF), and the ROM of ankle inversion/eversion, a peak angle of ankle inversion, and Integral EMG (IEMG) of PL and TA compared among 4 phases. Fifteen male subjects with no symptoms of ankle joint problems participated in this research. The ROM of ankle inversion/ eversion during the side-hop test was 27 ± 3.8° (mean ± SD), and there was a significant difference in the ROM of ankle inversion/eversion among 4 phases (p < 0.05). The phase in which the widest ROM was presented was the MF. A peak angle of the ankle inversion at MC was significantly greater than at LC and MF (p <0.05). A peak angle of the ankle inversion at LF was significantly greater than at LC and MF. The PL remained contracting with 50-160% of maximal voluntary contraction (MVC). The IEMGs of PL in both the contact phases were significantly greater than in both the flight phases (p < 0.05). In addition, the PL activity at LC was significantly greater than at MC. The TA remained contracting at 50-80% of MVC through the side-hop test. The IEMG of TA at both the contact phases was significantly greater than at 2 flight phases. However, there was no significant difference between LC and MF. Results of this study could be useful as basic data when evaluating the validity of the side-hop test for patients with ankle sprain. © 2011 National Strength and Conditioning Association.


Okita K.,Hokusho University | Kinugawa S.,Hokkaido University | Tsutsui H.,Hokkaido University
Circulation Journal | Year: 2013

Chronic heart failure (CHF) is characterized as a clinical disorder displaying exercise intolerance; patients typically complain of early muscular fatigue. Previously, it was thought to be simply a failure of perfusion to the exercising musculature and consequent early onset of intramuscular acidosis in CHF. However, improved hemodynamics by cardiotonic agents did not lead to an increase in exercise tolerance. Later studies have shown that intrinsic skeletal muscle abnormalities exist in patients with CHF and could induce the early anaerobic metabolism that limits exercise tolerance. We review the clinical importance of skeletal muscle abnormalities in patients with CHF. Considering the significance of peripheral muscle abnormalities and their development might help physicians and researchers better understand the mechanisms of well-established exercise training and pharmacological therapies that have been shown to improve the prognosis for CHF, and thus develop potential novel therapies.


Yamamoto K.,Hokusho University | Matsuzawa M.,Hokusho University
Gait and Posture | Year: 2013

The dynamic quantification of jump ability is useful for sports performance evaluation. We developed a force measurement system using the Wii Balance Board (WBB). This study was conducted to validate the system in comparison with a laboratory-grade force plate (FP). For a static validation, weights of 10-180. kg were put progressively on the WBB put on the FP. The vertical component of the ground reaction force (vGRF) was measured using both devices and compared. For the dynamic validation, 10 subjects without lower limb pathology participated in the study and performed vertical jumping twice on the WBB on the FP. The range of analysis was set from the landing after the first jump to taking off of the second jump. The peak values during the landing phase and jumping phase were obtained and the force-time integral (force impulse) was measured. The relations of the values measured using each device were compared using Pearson's correlation coefficient test and Bland-Altman plots (BAP). Significant correlation (. P<. .01, r=. .99) was found between the values of both devices in the static and the dynamic test. Examination of the BAP revealed a proportion error in the landing phase and showed no relation in the jumping phase between the difference and the mean in the dynamic test. The WBB detects the vGRF in the jumping phase with high precision. © 2012 Elsevier B.V.


Horiuchi M.,Japan Institute for Environmental Sciences | Horiuchi M.,Hokusho University | Muraki S.,Kyushu University | Horiuchi Y.,Health Sciences University of Hokkaido | And 2 more authors.
International Journal of Industrial Ergonomics | Year: 2014

This study investigated the effects of pushing a wheelchair on the energy cost of walking (Cw; defined as the ratio of the steady-state oxygen consumption to the walking speed) and economical speed (ES) on the level and ±5% gradients. Eight pairs were formed from twelve young men to minimize variation in body weight between pushing and assisted participants. The State Trait Anxiety Inventory (STAI) test was conducted to evaluate wheelchair occupants' anxiety before and after each trial. The Cw values were significantly higher when pushing a wheelchair on the uphill gradient at more than 45m/min. ES was significantly lower when pushing a wheelchair on the level (-8.5%) and uphill gradient (-9.1%), but not on the downhill gradient (-0.3%). Individual ES was also estimated using the concept of "Froude number", and "estimated" ES was significantly correlated with "measured" ES even when pushing a wheelchair on the downhill gradient. The STAI score was not significantly increased except at 105m/min, regardless of gradient. These results indicated that the fastest walking speed without an enhancement in wheelchair occupants' anxiety corresponds to ES when pushing a wheelchair with a seated occupant on all gradients, at least in young fit men. Relevance to industry: This study provides information on alterations in ES while pushing a wheelchair on different gradients, with the associated perspective of wheelchair occupants' anxiety. The results are useful for reducing energy expenditure and/or avoiding the early onset of fatigue in wheelchair assistants without increasing wheelchair occupants' anxiety. © 2013 Elsevier B.V.

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