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Ebetsu, Japan

Hokusho University is a private university in Ebetsu, Hokkaido, Japan. The predecessor of the school was founded in 1939 under the name Hokkaido Women's College. It was chartered as a junior women's college in 1963. It became a four-year college in 1997. The present name was adopted in 2007. Wikipedia.

Inoue N.,Hokkaido University | Kinugawa S.,Hokkaido University | Suga T.,Hokkaido University | Yokota T.,Hokkaido University | And 4 more authors.
American Journal of Physiology - Heart and Circulatory Physiology | Year: 2012

Angiotensin II (ANG II)-induced oxidative stress has been known to be involved in the pathogenesis of cardiovascular diseases. We have reported that the oxidative stress in skeletal muscle can limit exercise capacity in mice (16). We thus hypothesized that ANG II could impair the skeletal muscle energy metabolism and limit exercise capacity via enhancing oxidative stress. ANG II (50 ng·kg -1·min -1) or vehicle was infused into male C57BL/6J mice for 7 days via subcutaneously implanted osmotic minipumps. ANG II did not alter body weight, skeletal muscle weight, blood pressure, cardiac structure, or function. Mice were treadmill tested, and expired gases were analyzed. The work to exhaustion (vertical distance × body weight) and peak oxygen uptake were significantly decreased in ANG II compared with vehicle. In mitochondria isolated from skeletal muscle, ADP-dependent respiration was comparable between ANG II and vehicle, but ADP-independent respiration was significantly increased in ANG II. Furthermore, complex I and III activities were decreased in ANG II. NAD(P)H oxidase activity and superoxide production by lucigenin chemiluminescence were significantly increased in skeletal muscle from ANG II mice. Treatment of ANG II mice with apocynin (10 mmol/l in drinking water), an inhibitor of NAD(P)H oxidase activation, completely inhibited NAD(P)H oxidase activity and improved exercise capacity, mitochondrial respiration, and complex activities in skeletal muscle. ANG II-induced oxidative stress can impair mitochondrial respiration in skeletal muscle and limit exercise capacity. © 2012 the American Physiological Society.

Yoshida M.,Hokusho University | Saho Y.,Sapporo Medical University | Katayose M.,Sapporo Medical University
Journal of Sport Rehabilitation | Year: 2010

Context: Studies have reported the difference in humeral retroversion (HR) between the dominant and nondominant side in throwing athletes. However, there are few data concerning HR for the rest of the population. In addition, the relationship between HR and external (ER) and internal rotation (IR) at 90° shoulder abduction has not been thoroughly investigated. Objectives: To investigate the reliability of ultrasound methodology to measure HR. In addition, using ultrasonography, the authors compare HR between the dominant and nondominant sides in healthy adult men and determine the relationship between HR and ER and IR at 90° of shoulder abduction. Design: Descriptive study. Setting: Laboratory. Participants: Thirty-seven healthy male subjects (age 21.9 ± 2.4 y, height 172.9 ± 5.3 cm, weight 66.0 ± 7.2 kg) with no history of shoulder or elbow injury, recruited from a convenience sample, volunteered for the study. Main Outcome Measures: Subjects were bilaterally examined for HR, ER, and IR. HR was measured by ultrasonography. Results: The intrarater reliability of the ultrasound methodology was .91-.98, and the interrater reliability was .97. The HR angle on the dominant side (mean ± SD: 68.5° ± 10.0°) was significantly greater than that of the nondominant side (58.0° ± 8.4°; P < .001). ER on the dominant side was significantly greater than on the nondominant side (P < .001), whereas IR on the dominant side was significantly smaller than on the nondominant side (P < .001). Total arc of motion for the dominant side was not significantly different from that of the nondominant side (P = .335). Conclusion: In the current study, ultrasound methodology to measure HR showed high interrater reliability, as well as high intrarater reliability. In addition, this study indicates that healthy Japanese adult men have side-to-side differences in HR. © 2010 Human Kinetics, Inc.

Morita N.,Hokkaido University of Education | Okita K.,Hokusho University
Circulation Journal | Year: 2013

Background: This study compared older men and women with cardiovascular (CV) risk factors in terms of the effects of a 6-month exercise intervention on high-sensitivity C-reactive protein (hsCRP) levels, blood pressure (BP) and other risk factors. Methods and Results: Sixty older (age 61-79) overweight men and 71 such women with 2 or more risk factors (ie, systolic BP 130-179 mmHg, non-fasting blood glucose 110-139 mg/dl, and low-density lipoprotein cholesterol 120-219 mg/dl) participated in a 6-month exercise intervention. The exercise program consisted of moderate-intensity bicycle exercise for ~40 min, performed on average 2.5 times per week. Systolic and diastolic BP reductions were found to be greater in women than in men (SBP, -10.6 vs. -5.5 mmHg; DBP, -6.2 vs. -3.3 mmHg; both P<0.05). Decreases in body mass index were larger in women than in men (P<0.05). There was no significant gender difference in the changes in blood glucose and lipid profiles and hsCRP levels. After adjustment for confounders (exercise frequency, weight loss, age, and baseline values), there were still significant gender differences in the SBP and DBP reductions. hsCRP reduction were similar in both genders even after adjusting for weight loss. Conclusions: There could be gender differences in the beneficial effects of exercise training on the potent CV risk factors of BP and body weight, but not on hsCRP.

Yoshida M.,Hokusho University | Taniguchi K.,Sapporo Medical University | Katayose M.,Sapporo Medical University
Journal of Strength and Conditioning Research | Year: 2011

Yoshida, M, Taniguchi, K, and Katayose, M. Analysis of muscle activity and ankle joint movement during the side-hop test. J Strength Cond Res 25(8): 2255-2264, 2011-Functional performance tests (FPTs) that consist of movements, such as hopping, landing, and cutting, provide useful measurements. Although some tests have been established for kinematic studies of the knee joint, very few tests have been established for the ankle joint. To use the FPT as a test battery for patients with an ankle sprain, it is necessary to document typical patterns of muscle activation and range of motion (ROM) of the ankle joint during FPTs. Therefore, the purpose of this study was to investigate the pattern of the ROM of the ankle inversion/ eversion and the muscle activity of the peroneus longus muscle (PL) and the tibial anterior muscle (TA) in normal subjects during the side-hop test. To emphasize the characteristics of ROM and electromyography (EMG) at each phase, the sidehop tests were divided into 4 phases: lateral-hop contact phase (LC), lateral-hop flight phase (LF), medial hop contact phase (MC), and medial hop flight phase (MF), and the ROM of ankle inversion/eversion, a peak angle of ankle inversion, and Integral EMG (IEMG) of PL and TA compared among 4 phases. Fifteen male subjects with no symptoms of ankle joint problems participated in this research. The ROM of ankle inversion/ eversion during the side-hop test was 27 ± 3.8° (mean ± SD), and there was a significant difference in the ROM of ankle inversion/eversion among 4 phases (p < 0.05). The phase in which the widest ROM was presented was the MF. A peak angle of the ankle inversion at MC was significantly greater than at LC and MF (p <0.05). A peak angle of the ankle inversion at LF was significantly greater than at LC and MF. The PL remained contracting with 50-160% of maximal voluntary contraction (MVC). The IEMGs of PL in both the contact phases were significantly greater than in both the flight phases (p < 0.05). In addition, the PL activity at LC was significantly greater than at MC. The TA remained contracting at 50-80% of MVC through the side-hop test. The IEMG of TA at both the contact phases was significantly greater than at 2 flight phases. However, there was no significant difference between LC and MF. Results of this study could be useful as basic data when evaluating the validity of the side-hop test for patients with ankle sprain. © 2011 National Strength and Conditioning Association.

Yokota T.,Hokkaido University | Yokota T.,Copenhagen University | Kinugawa S.,Hokkaido University | Yamato M.,Fukuoka University | And 11 more authors.
Diabetes Care | Year: 2013

OBJECTIVE-Systemic oxidative stress is associated with insulin resistance and obesity. We tested the hypothesis that systemic oxidative stress is linked to lower aerobic capacity and skeletal muscle dysfunction in metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS-The incremental exercise testing with cycle ergometer was performed in 14 male patients with MetS and 13 age-, sex-, and activity-matched healthy subjects. Systemic lipid peroxidation was assessed by serum thiobarbituric acid reactive substances (TBARS), and systemic antioxidant defense capacity was assessed by serum total thiols and enzymatic activity of superoxide dismutase (SOD). To assess skeletal muscle energy metabolism, we measured high-energy phosphates in the calf muscle during plantar flexion exercise and intramyocellular lipid (IMCL) in the resting leg muscle, using 31P- and 1protonmagnetic resonance spectroscopy, respectively. RESULTS-Serum TBARS were elevated (12.4 ± 7.1 vs. 3.7 ± 1.1 μmol/L; P < 0.01), and serum total thiols and SOD activity were decreased (290.8 ± 51.2 vs. 398.7 ± 105.2 μmol/L, P < 0.01; and 22.2 ± 8.4 vs. 31.5 ± 8.5 units/L, P < 0.05, respectively) in patients with MetS compared with healthy subjects. Peak VO2 and anaerobic threshold normalized to body weight were significantly lower in MetS patients by 25 and 31%, respectively, and inversely correlated with serum TBARS (r = 20.49 and r = 20.50, respectively). Moreover, muscle phosphocreatine loss during exercise was 1.4-fold greater in patients with MetS (P,0.05), and IMCL content was 2.9-fold higher in patients with MetS (P < 0.01), indicating impaired skeletal muscle energy metabolism, and these indices positively correlated with serum TBARS (r = 0.45 and r = 0.63, respectively). CONCLUSIONS-Systemic oxidative stress was associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients with MetS. © 2013 by the American Diabetes Association.

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