Kanazawa-shi, Japan
Kanazawa-shi, Japan

Hokuriku University is a private university located in Kanazawa, Ishikawa, Japan. Founded in 1975, the university is locally nicknamed Hokudai, though typically the term is used nationwide to refer to Hokkaido University. It was originally founded as a single-department college with the Faculty of Pharmaceutical science. Later, the Faculty of Foreign Languages and the Faculty of Law were established in 1987 and 1992, respectively. The School of Future Learning was established in 2004, making it the newest faculty in the university.As of the end of March 2005, Hokuriku University owns 4.44% of the outstanding stock in FM Tokyo. Wikipedia.


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Takahashi T.,Hokuriku University
Clinical calcium | Year: 2016

It is necessary to achieve pharmacotherapy appropriate to individual patient with respect to effectiveness and safety. Since drugs are given to patients with various kinds of diseases and conditions, in which pharmacokinetics greatly changes, we need to understand the relationship between pharmacokinetics and patient's condition, minimizing the individual differences in drug efficacy and toxicity. In this report, I outline the alteration of pharmacokinetics of anti-osteoporotic drugs in patients with various diseases and conditions.


Patent
University of Fukui, Hokuriku University and Taiyo Nippon Sanso | Date: 2015-02-18

The present invention provides a compound represented by the formula (I):


Patent
University of Fukui, Hokuriku University and Taiyo Nippon Sanso | Date: 2013-03-28

The present invention provides a compound represented by the formula (I): or a salt thereof; and a method of quantitatively analyzing an amino group-containing target substance, including labeling a target substance in samples by using, as a labeling compound, two or more of such compounds having a mutually different mass due to isotope labeling, to confer a mass difference to the target substance between two or more samples, and the like.


Koga K.,Hokuriku University | Takarada N.,Hokuriku University | Takada K.,Kyoto Pharmaceutical University
European Journal of Pharmaceutics and Biopharmaceutics | Year: 2010

Our goal was to develop safe and stable multilayer emulsions capable of enhancing intestinal absorption of biopharmaceutics classification system (BCS) class III drugs. First, w/o emulsions were prepared using calcein as a model BCS class III compound and condensed ricinoleic acid tetraglycerin ester as a hydrophobic emulsifier. Then water-in-oil-in-water (w/o/w) emulsions were prepared with shirasu porous glass (SPG) membranes. Particle size analyses and calcein leakage from oil droplets in w/o/w emulsions led us to select stearic acid hexaglycerin esters (HS-11) and Gelucire 44/14 as hydrophilic emulsifiers. Analyses of the absorption-enhancing effects of w/o/w emulsions on intestinal calcein absorption in rats showed that calcein bioavailability after intraduodenal (i.d.) administration of HS-11 or Gelucire 44/14 + polyvinyl alcohol (PVA) w/o/w emulsions prepared with 0.1-μm pore-sized SPGs was significantly higher than that of the calcein control. However, serum calcein concentration vs. time profiles after i.d. administration of w/o/w emulsions prepared with 1.1-μm and 30-μm pore-sized SPGs and an emulsion prepared with a calcein-containing outer water phase were comparable to control profiles. These results suggested that HS-11 or Gelucire 44/14 + PVA are safe outer water phase additives and that 0.1-μm pore-sized SPGs are important for preparing w/o/w emulsions that enhanced intestinal calcein absorption. © 2009 Elsevier B.V. All rights reserved.


Silver triflate promotes the 6-exo-dig mode cyclization of the N-(2-ethynylphenyl)thioureas, which were easily obtained from the o-ethynylphenyl isothiocyanates and the primary amines, to provide the 2-imino-4-methylidene-1H-benzo[d][1,3]thiazines as the sole product in excellent yields. The secondary amines reacted with the o-ethynylphenyl isothiocyanates to give both the 6-exo and 5-endo-dig mode cyclization products under the same conditions. © 2011 Elsevier Ltd. All rights reserved.


Quantification of BMD is being used as the main method to diagnose osteoporosis and measurement accuracy has dramatically improved. However, essential clinical parameters of osteoporosis include more dynamic markers such as bone metabolic markers. Bone metabolism undergoes daily dynamic changes, and even with the same BMD, the metabolic state differs and the pathologic significance also differs. Therefore, to use BMD measurement as a dynamic marker, one must wait for an observation period of 6 months to 1 year before remeasurement, whereas bone metabolic markers accurately reflect the state of bone metabolism at the point in time of the measurement. Bone metabolic markers can also be used as a guide to selecting pharmacotherapy. When there is doubt about choosing a drug, the use of bone metabolic markers can enable more appropriate selection. Furthermore, to evaluate the effects of drug therapy on disease improvement, assessing the state of bone metabolism at the time of diagnosis is recommended whenever possible. However, if a decision is made to select treatment with little influence on bone metabolism, then measuring bone metabolic markers to monitor drug treatment effects has little clinical significance. Recently the clinical application of bone metabolic markers have been achieved significant progress and the measurements of these indices give us better understanding of pathological of osteoporosis. Therefore, it is very important to guide the proper application and assessment of bone metabolic markers in clinical practice.


The preparation of the five- to nine-membered selenium-containing heterocycles using the intramolecular cyclization of selenols and relative compounds is mainly described in this review based on recent advances in our findings. Some reactions and chemical properties of the obtained products are also described. © 2011 The Japan Institute of Heterocyclic Chemistry.


Kaname M.,Hokuriku University | Sashida H.,Hokuriku University
Tetrahedron Letters | Year: 2011

The o-bromoethynylbenzenes were lithiated with tert-BuLi in Et2O followed by treatment with isoselenocyanate, and then EtOH was added as a proton source, producing the desired (Z)-3-methylidenebenzo[c]selenophenes as the sole 5-exo-dig mode cyclization products in one-pot with yields ranging from 54-87%. The iodocyclization of the o-ethynylphenyllithium with isoselenocyanate stereoselectively gave the (E)-1′-iodo-3-methylidenebenzo[c]selenophene, which was converted into the more functionalized benzo[c]selenophenes via the Suzuki- and Sonogashira-coupling reactions. © 2011 Elsevier Ltd. All rights reserved.


Yazawa K.,Hokuriku University
Antiviral chemistry & chemotherapy | Year: 2011

We examined the anti-influenza virus activity of tricin, 4',5,7-trihydroxy-3',5'-dimethoxyflavone, against five viruses: A/Solomon islands/3/2006 (H1N1), A/Hiroshima/52/2005 (H3N2), A/California/07/2009 (H1N1pdm), A/Narita/1/2009 (H1N1pdm) and B/Malaysia/2506/2004 strains in vitro and against A/PR/8/34 virus in vivo. The effect of tricin was studied by an infectious virus yield reduction assay. The anti-influenza virus mechanism of the tricin was examined by western blot analysis, real-time reverse transcriptase PCR analysis, haemagglutination inhibition (HI) assay and neuraminidase (NA) inhibition assay. The anti-influenza virus efficacy of tricin was further examined in a murine influenza virus infection model. Tricin of 3.3 to 30 μM significantly reduced seasonal A (H1N1), (H3N2) viruses, novel A (H1N1pdm) virus, as well as B virus in a dose-dependent manner. The 50% effective concentrations of tricin were 3.4 μM for seasonal A (H3N2) virus, 4.9 μM for B virus and 8.2 μM for A/Narita (H1N1pdm) virus. Tricin decreased the expression of haemagglutinin (HA) protein and matrix (M) protein, and messenger RNA expression of HA and M of influenza virus in the infected cells. Tricin exhibited little or no effects on influenza virus HI and NA activities. In the mouse infection model, tricin was significantly effective in reducing body weight loss, and also effective in prolonging survival times of infected mice. Tricin was indicated to possess anti-influenza virus activity and to ameliorate body weight loss and survival rate of influenza-A-virus-infected mice. Tricin is a novel compound with potential anti-influenza virus activity in vitro and in vivo.


Kaname M.,Hokuriku University | Minoura M.,Kitasato University | Sashida H.,Hokuriku University
Tetrahedron Letters | Year: 2011

A convenient and successful one-pot preparation of the 2- aminobenzoselenazoles via the phenylselenoureas has been accomplished by the copper-catalyzed ligand-free reaction of the 2-iodoanilines and isoselenocyanates; the intermediate, selenoureas, were isolated, and quantitatively transformed into the selenazaoles. © 2010 Elsevier Ltd. All rights reserved.

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