Hokkaido University of Education is national, public university, administered by the government of Japan. It has five campuses in Hokkaido, Japan. The main campus is located on the outskirts of Sapporo, the capital of Hokkaido. Hokkaido University of Education, Sapporo is the largest campus, but still only has a little over 1000 students. Other campuses are located in Asahikawa, Kushiro, Hakodate, and Iwamizawa. HUE is primarily dedicated to training teachers, and each of the campuses have associated public schools where students may practice teaching. Wikipedia.
Nojima T.,Tohoku University |
Kimura K.-i.,Hokkaido University of Education |
Koganezawa M.,Tohoku University |
Yamamoto D.,Tohoku University
Current Biology | Year: 2010
Synapses mediate inductive interactions for the proper development of pre- and postsynaptic cells: presynaptic electrical activities and synaptic transmission ensure the organization of postsynaptic structures, whereas neurotrophins produced in postsynaptic cells support the survival and enlargement of presynaptic partners . In Drosophila, a motor nerve has been implicated in the induction of the muscle of Lawrence (MOL) [2-4], the formation of which is male specific and depends on the neural expression of fruitless (fru) [5, 6], a neural sex-determinant gene [7, 8]. Here we report the identification of a single motoneuron essential for inducing the MOL, which we call the MOL-inducing (Mind) motoneuron. The MOL is restored in fru mutant males, which otherwise lack the MOL, if the fru+ transgene is selectively expressed in the Mind motoneuron by mosaic analysis with a repressible cell marker . We further demonstrate that synaptic outputs from the Mind motoneuron are indispensable to MOL induction, because the blockage of synaptic transmission by shibirets (shits) during the critical period in development abolished the MOL formation in males. Our finding that sex-specific neurons instruct sexually dimorphic development of their innervating targets through synaptic interactions points to the novel mechanism whereby the pre- and postsynaptic partners coordinately establish their sexual identity. © 2010 Elsevier Ltd. All rights reserved.
Kito N.,Hokkaido University of Education |
Ohkuro Y.,879 A203
Quaternary International | Year: 2012
A high-resolution (decade time-resolution) analysis of pollen from Ayameshitsugen Mire (750. m a.s.l.), Hokkaido, Japan, focused on vegetation response to climate change during the last glacial-interglacial transition. The succession analyzed covers the 14,050-8450. cal. BP interval. Pollen records indicate that the area around the study site was occupied by boreal Betula-Picea-Abies forest during the late glacial period. Picea began to decrease at 11,600. cal. BP and disappeared at 11,000. cal. BP. Temperate forest elements began to increase about 100 years after the beginning of the decrease in Picea. Changing pollen assemblages over the early Holocene 11,600-8450. cal. BP interval indicate that vegetation has not been in equilibrium with climate since the onset of Holocene conditions. Higher abundance of Ulmus and Juglans than at present characterizes early Holocene vegetation. A distinct cooling event coinciding with the Younger Dryas stade in the region only occurred 12,700-12,450. cal. BP. The stade was less pronounced than in the North Atlantic region, and a gradual increase in Picea and Betula during the stade indicates gradual climatic amelioration in the region. Mire vegetation did not show a simultaneous response to the onset of Holocene warming. © 2011.
Kimura K.-I.,Hokkaido University of Education
Development Growth and Differentiation | Year: 2011
Currently, sex differences in behavior are believed to result from sexually dimorphic neural circuits in the central nervous system (CNS). Drosophila melanogaster is a common model organism for studying the relationship between brain structure, behavior, and genes. Recent studies of sex-specific reproductive behaviors in D. melanogaster have addressed the contribution of sexual differences in the CNS to the control of sex-specific behaviors and the development of sexual dimorphism. For example, sexually dimorphic regions of the CNS are involved in the initiation of male courtship behavior, the generation of the courtship song, and the induction of male-specific muscles in D. melanogaster. In this review, I discuss recent findings about the contribution of cell death to the formation of sexually dimorphic neural circuitry and the regulation of sex-specific cell death by two sex determination factors, Fruitless and Doublesex, in Drosophila. © 2011 The Author. Journal compilation © 2011 Japanese Society of Developmental Biologists.
Morita N.,Hokkaido University of Education |
Okita K.,Hokusho University
Circulation Journal | Year: 2013
Background: This study compared older men and women with cardiovascular (CV) risk factors in terms of the effects of a 6-month exercise intervention on high-sensitivity C-reactive protein (hsCRP) levels, blood pressure (BP) and other risk factors. Methods and Results: Sixty older (age 61-79) overweight men and 71 such women with 2 or more risk factors (ie, systolic BP 130-179 mmHg, non-fasting blood glucose 110-139 mg/dl, and low-density lipoprotein cholesterol 120-219 mg/dl) participated in a 6-month exercise intervention. The exercise program consisted of moderate-intensity bicycle exercise for ~40 min, performed on average 2.5 times per week. Systolic and diastolic BP reductions were found to be greater in women than in men (SBP, -10.6 vs. -5.5 mmHg; DBP, -6.2 vs. -3.3 mmHg; both P<0.05). Decreases in body mass index were larger in women than in men (P<0.05). There was no significant gender difference in the changes in blood glucose and lipid profiles and hsCRP levels. After adjustment for confounders (exercise frequency, weight loss, age, and baseline values), there were still significant gender differences in the SBP and DBP reductions. hsCRP reduction were similar in both genders even after adjusting for weight loss. Conclusions: There could be gender differences in the beneficial effects of exercise training on the potent CV risk factors of BP and body weight, but not on hsCRP.
Bradshaw R.H.W.,University of Liverpool |
Kito N.,Hokkaido University of Education |
Giesecke T.,University of Gottingen
Forest Ecology and Management | Year: 2010
The Holocene histories of three species of Fagus with related autecologies (F. sylvatica, F. grandifolia and F. crenata) are reviewed to compare factors that have affected the long-term dynamics of the species distributions. There are similar climatic controls exerted on all three species and their spreading histories were strongly influenced by the location of glacial refugia and the apparent establishment of outlying founder populations early in the Holocene. Under ideal growth conditions all three species showed similar population doubling rates, with estimated spreading rates of less than 100 m per year. Stand-scale disturbance is shown to have facilitated the spread of F. sylvatica at its northern distribution limits. © 2009 Elsevier B.V. All rights reserved.