Hokkaido University , or Hokudai , is one of the national universities of Japan. It is a member of the National Seven Universities, which were established as the best national higher education or research institute. It is located in downtown Sapporo, just north of Sapporo Station, and stretching approximately 2.4 kilometers northward. It is considered as one of the top universities in Japan. Wikipedia.
Hokkaido University and Nissan Chemical Industries Ltd. | Date: 2017-03-15
A metal-organic framework (MOF) having the function of controlling the release of guests is provided in which reversible release control is possible and release control can be rapidly performed and which is capable of accommodating the release of various guest molecules. The metal-organic framework comprises both an organic ligand having two or more functional groups (coordinating functional groups) capable of coordinating to a metal atom and metal ions that combine with the coordinating functional groups of the organic ligand, and has a structure in which one metal ion has combined with two or more of the coordinating functional groups to connect multiple molecules of the organic ligand. The metal-organic framework/stimulus-responsive polymer composite was obtained by affixing a stimulus-responsive polymer to at least some of the surface of the metal-organic framework. The stimulus-responsive polymer may be affixed by bonding to the organic ligand.
Fujifilm Co. and Hokkaido University | Date: 2017-02-08
Provided is a microneedle array which can improve an antibody production ability and makes it possible to simply administer an influenza vaccine. The microneedle array includes a needle portion, which contains an inactivated whole virion influenza vaccine, and a sheet portion. Also provided is an administration method in which the microneedle array is administered and then administered secondly after an interval of equal to or greater than 24 hours and less than 2 months.
Hokkaido University | Date: 2017-03-29
A lipid membrane structure encapsulating an siRNA inside thereof and containing a lipid compound of the formula (I) as a lipid component (R^(1) and R^(2) represent CH_(3)-(CH_(2))_(n)-CH=CH-CH_(2)-CH=CH-(CH_(2))_(m)-, n represents an integer of 3 to 5, m represents an integer of 6 to 10, p represents an integer of 2 to 7, and R^(3) and R^(4) represent a C_(1-4) alkyl group or a C_(2-4) alkenyl group.
Hokkaido University | Date: 2017-01-04
[Problem] The purpose of the present invention is to provide a novel pharmaceutical for use in cellular immunotherapy for the prevention and/or treatment of diseases in which Th2-type cytokines are effective, such as cardiovascular disease and the like. [Solution] The present invention relates to a pharmaceutical containing dendritic cells pulsed with -galactosylceramide for the prevention and/or treatment of diseases in which Th2-type cytokines are effective, and a method for producing the same.
Hokkaido University | Date: 2017-03-01
In the latent heat storage body (100) according to the present invention, the surface of a core particle (10) composed of a latent heat storage material of a metal or an alloy is coated with an oxidized film of a compositional element of the core particle (10). Hence, the step of separately fabricating the core particle and the oxidized film (20) corresponding to a shell accommodating the core particle and accommodating the core particle inside the shell becomes unnecessary. Further since the core particle exhibits no expansion when transforming from a solid phase to a liquid phase, the component of the melted latent heat storage material stays inside the space covered with the oxidized film and the oxidized film is never damaged. Further, the oxidized film (20) can be made chemically stable.
NEC Corp, Hokkaido University and INC Research | Date: 2017-03-15
An object detection device 5 of an object detection system 1 includes an object detection determination unit 7 including a bird candidate determination unit 17 for determining, from an image acquired by imaging a moving object, whether or not the moving object is a specific detection subject (bird in this case), and a bird type/attitude estimation unit 19 for estimating, based on a contour of the moving object determined to be the bird by the bird candidate determination unit 17 and a WFM library 9 storing contour shape information, which is a contour prepared for each of types of the specific detection subject (types of the bird in this case), a type of the moving object out of the types of the specific detection subject.
Hokkaido University | Date: 2017-05-10
The problems: The present invention aims at providing a method for controlling red mites by eliciting an immune response against them in a domestic animal, and a vaccine antigen and a vaccine against red mites that can be used therefor. The object aims to provide: A method for eliciting an immune response specific for red mites in a domestic animal, comprising the step of administering to the domestic animal a protein consisting of the amino acid sequence set forth in SEQ ID NO. 1, a protein consisting of the amino acid sequence set forth in SEQ ID NO. 2, and/or an immunological equivalent thereof. According to the present invention, an immune response specific for red mites can be elicited in a domestic animal, and red mites can be controlled by inhibiting the function of the target molecule within the red mites that has sucked the blood of the domestic animal.
Hokkaido University, Fujirebio Inc. and SRL Inc. | Date: 2016-03-24
The present invention provides a novel marker for diagnosing fibromyalgia syndrome (FMS). More specifically, the present invention provides a method for diagnosing FMS, comprising measurement of (1) the relative frequency of MAITs to the total T cells in a sample; or (2) the expression level of one or more surface antigens selected from the group consisting of CD4, CD8, CCR4, CCR7, CXCR1, NKp80, CD150, CD107a, CD8, CD44 and CXCR4 for MAITs in a sample, wherein the sample is a biological sample collected from a human; and a diagnosis kit for FMS, comprising a means for measuring (1) the relative frequency of MAITs to the total T cells in a sample; or (2) the expression level of one or more surface antigens selected from the group consisting of CD4, CD8, CCR4, CCR7, CXCR1, NKp80, CD150, CD107a, CD8, CD44 and CXCR4 for MAITs in a sample, wherein the sample is a biological sample collected from a human.
Hokkaido University and Clariant | Date: 2017-05-24
The present invention addresses the problem of providing a solid catalyst capable of achieving high selectivity and high yield for isosorbide, preferably at the same time, in a dehydration reaction by which dianhydrosugar alcohol is obtained from a sugar alcohol, particularly, in a dehydration reaction by which isosorbide is obtained from sorbitol. The above-mentioned problem is solved by a solid catalyst for a dehydration reaction for preparing dianhydrosugar alcohol from sugar alcohol, said catalyst including an H-type zeolite having an atomic composition ratio of Si to Al (Si/Al) of more than 20.
Fujikura Ltd and Hokkaido University | Date: 2017-05-24
The effective refractive indexes of core elements 10a to 10c are different from each other, and the effective refractive indexes of the core elements 10a to 10c and the effective refractive index of a second core 21 are different from each other. No core is disposed at the lattice point of a triangular lattice of a first layer LY1. First cores 11a and 11b of the core elements 10a and 10b are disposed at the lattice points of a second layer LY2. A first core 11c of the core element 10c and the second core 21 are alternately disposed at the lattice points of a third layer LY3. In a fourth layer LY4, no core is disposed at six lattice points, and the first cores 11a and 11b of the core elements 10a and 10b are disposed at the other lattice points. The second cores 21 are adjacent to the lattice points of the fourth layer LY4, at which no core is disposed. The effective refractive indexes of the core elements adjacent to each other are different from each other.