Sapporo, Japan
Sapporo, Japan

Hokkaido University , or Hokudai , is one of the national universities of Japan. It is a member of the National Seven Universities, which were established as the best national higher education or research institute. It is located in downtown Sapporo, just north of Sapporo Station, and stretching approximately 2.4 kilometers northward. It is considered as one of the top universities in Japan. Wikipedia.


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Patent
Hokkaido University and Nissan Chemical Industries Ltd. | Date: 2015-03-09

A metal-organic framework (MOF) having the function of controlling the release of guests is provided in which reversible release control is possible and release control can be rapidly performed and which is capable of accommodating the release of various guest molecules. The metal-organic framework comprises both an organic ligand having two or more functional groups (coordinating functional groups) capable of coordinating to a metal atom and metal ions that combine with the coordinating functional groups of the organic ligand, and has a structure in which one metal ion has combined with two or more of the coordinating functional groups to connect multiple molecules of the organic ligand. The metal-organic framework/Stimulus-responsive polymer composite was obtained by affixing a stimulus-responsive polymer to at least some of the surface of the metal-organic framework. The stimulus-responsive polymer may be affixed by bonding to the organic ligand.


In the latent heat storage body (100) according to the present invention, the surface of a core particle (10) composed of a latent heat storage material of a metal or an alloy is coated with an oxidized film of a compositional element of the core particle (10). Hence, the step of separately fabricating the core particle and the oxidized film (20) corresponding to a shell accommodating the core particle and accommodating the core particle inside the shell becomes unnecessary. Further since the core particle exhibits no expansion when transforming from a solid phase to a liquid phase, the component of the melted latent heat storage material stays inside the space covered with the oxidized film and the oxidized film is never damaged. Further, the oxidized film (20) can be made chemically stable.


Patent
Tohoku University and Hokkaido University | Date: 2015-05-08

An excitation light source emits excitation light to a target sample. An image sensor includes pixels arranged one-dimensionally or two-dimensionally, and receives measurement light from the sample according to the excitation light. A polarization selector arranged between the sample and image sensor includes pixels arranged one-dimensionally or two-dimensionally. Each pixel receives a corresponding portion of the measurement light, selects light having a polarization direction that corresponds to a driving signal applied to the pixels, and supplies this light to the image sensor. A measurement control unit supplies the cyclic driving signal having a first period T_(1 )and acquires data I_(1), I_(2), I_(3), and I_(4 )from each pixel of the image sensor for each exposure time segment T_(2)=T_(1)/4 obtained by dividing the first period T_(1 )by 4.


Patent
Hokkaido University and Nissan Chemical Industries Ltd. | Date: 2017-03-15

A metal-organic framework (MOF) having the function of controlling the release of guests is provided in which reversible release control is possible and release control can be rapidly performed and which is capable of accommodating the release of various guest molecules. The metal-organic framework comprises both an organic ligand having two or more functional groups (coordinating functional groups) capable of coordinating to a metal atom and metal ions that combine with the coordinating functional groups of the organic ligand, and has a structure in which one metal ion has combined with two or more of the coordinating functional groups to connect multiple molecules of the organic ligand. The metal-organic framework/stimulus-responsive polymer composite was obtained by affixing a stimulus-responsive polymer to at least some of the surface of the metal-organic framework. The stimulus-responsive polymer may be affixed by bonding to the organic ligand.


Provided is a microneedle array which can improve an antibody production ability and makes it possible to simply administer an influenza vaccine. The microneedle array includes a needle portion, which contains an inactivated whole virion influenza vaccine, and a sheet portion. Also provided is an administration method in which the microneedle array is administered and then administered secondly after an interval of equal to or greater than 24 hours and less than 2 months.


Patent
Hokkaido University | Date: 2017-03-29

A lipid membrane structure encapsulating an siRNA inside thereof and containing a lipid compound of the formula (I) as a lipid component (R^(1) and R^(2) represent CH_(3)-(CH_(2))_(n)-CH=CH-CH_(2)-CH=CH-(CH_(2))_(m)-, n represents an integer of 3 to 5, m represents an integer of 6 to 10, p represents an integer of 2 to 7, and R^(3) and R^(4) represent a C_(1-4) alkyl group or a C_(2-4) alkenyl group.


Patent
Hokkaido University | Date: 2017-01-04

[Problem] The purpose of the present invention is to provide a novel pharmaceutical for use in cellular immunotherapy for the prevention and/or treatment of diseases in which Th2-type cytokines are effective, such as cardiovascular disease and the like. [Solution] The present invention relates to a pharmaceutical containing dendritic cells pulsed with -galactosylceramide for the prevention and/or treatment of diseases in which Th2-type cytokines are effective, and a method for producing the same.


In the latent heat storage body (100) according to the present invention, the surface of a core particle (10) composed of a latent heat storage material of a metal or an alloy is coated with an oxidized film of a compositional element of the core particle (10). Hence, the step of separately fabricating the core particle and the oxidized film (20) corresponding to a shell accommodating the core particle and accommodating the core particle inside the shell becomes unnecessary. Further since the core particle exhibits no expansion when transforming from a solid phase to a liquid phase, the component of the melted latent heat storage material stays inside the space covered with the oxidized film and the oxidized film is never damaged. Further, the oxidized film (20) can be made chemically stable.


Patent
NEC Corp, Hokkaido University and INC Research | Date: 2017-03-15

An object detection device 5 of an object detection system 1 includes an object detection determination unit 7 including a bird candidate determination unit 17 for determining, from an image acquired by imaging a moving object, whether or not the moving object is a specific detection subject (bird in this case), and a bird type/attitude estimation unit 19 for estimating, based on a contour of the moving object determined to be the bird by the bird candidate determination unit 17 and a WFM library 9 storing contour shape information, which is a contour prepared for each of types of the specific detection subject (types of the bird in this case), a type of the moving object out of the types of the specific detection subject.


Hatakeyama S.,Hokkaido University
Nature Reviews Cancer | Year: 2011

Emerging clinical evidence shows that the deregulation of ubiquitin-mediated degradation of oncogene products or tumour suppressors is likely to be involved in the aetiology of carcinomas and leukaemias. Recent studies have indicated that some members of the tripartite motif (TRIM) proteins (one of the subfamilies of the RING type E3 ubiquitin ligases) function as important regulators for carcinogenesis. This Review focuses on TRIM proteins that are involved in tumour development and progression. © 2011 Macmillan Publishers Limited. All rights reserved.

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