Sapporo, Japan
Sapporo, Japan

Hokkaido University , or Hokudai , is one of the national universities of Japan. It is a member of the National Seven Universities, which were established as the best national higher education or research institute. It is located in downtown Sapporo, just north of Sapporo Station, and stretching approximately 2.4 kilometers northward. It is considered as one of the top universities in Japan. Wikipedia.


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Patent
Hokkaido University and Nissan Chemical Industries Ltd. | Date: 2017-03-15

A metal-organic framework (MOF) having the function of controlling the release of guests is provided in which reversible release control is possible and release control can be rapidly performed and which is capable of accommodating the release of various guest molecules. The metal-organic framework comprises both an organic ligand having two or more functional groups (coordinating functional groups) capable of coordinating to a metal atom and metal ions that combine with the coordinating functional groups of the organic ligand, and has a structure in which one metal ion has combined with two or more of the coordinating functional groups to connect multiple molecules of the organic ligand. The metal-organic framework/stimulus-responsive polymer composite was obtained by affixing a stimulus-responsive polymer to at least some of the surface of the metal-organic framework. The stimulus-responsive polymer may be affixed by bonding to the organic ligand.


Patent
Hokkaido University | Date: 2017-05-10

The problems: The present invention aims at providing a method for controlling red mites by eliciting an immune response against them in a domestic animal, and a vaccine antigen and a vaccine against red mites that can be used therefor. The object aims to provide: A method for eliciting an immune response specific for red mites in a domestic animal, comprising the step of administering to the domestic animal a protein consisting of the amino acid sequence set forth in SEQ ID NO. 1, a protein consisting of the amino acid sequence set forth in SEQ ID NO. 2, and/or an immunological equivalent thereof. According to the present invention, an immune response specific for red mites can be elicited in a domestic animal, and red mites can be controlled by inhibiting the function of the target molecule within the red mites that has sucked the blood of the domestic animal.


Patent
Hokkaido University, Fujirebio Inc. and SRL Inc. | Date: 2016-03-24

The present invention provides a novel marker for diagnosing fibromyalgia syndrome (FMS). More specifically, the present invention provides a method for diagnosing FMS, comprising measurement of (1) the relative frequency of MAITs to the total T cells in a sample; or (2) the expression level of one or more surface antigens selected from the group consisting of CD4, CD8, CCR4, CCR7, CXCR1, NKp80, CD150, CD107a, CD8, CD44 and CXCR4 for MAITs in a sample, wherein the sample is a biological sample collected from a human; and a diagnosis kit for FMS, comprising a means for measuring (1) the relative frequency of MAITs to the total T cells in a sample; or (2) the expression level of one or more surface antigens selected from the group consisting of CD4, CD8, CCR4, CCR7, CXCR1, NKp80, CD150, CD107a, CD8, CD44 and CXCR4 for MAITs in a sample, wherein the sample is a biological sample collected from a human.


The present invention addresses the problem of providing a solid catalyst capable of achieving high selectivity and high yield for isosorbide, preferably at the same time, in a dehydration reaction by which dianhydrosugar alcohol is obtained from a sugar alcohol, particularly, in a dehydration reaction by which isosorbide is obtained from sorbitol. The above-mentioned problem is solved by a solid catalyst for a dehydration reaction for preparing dianhydrosugar alcohol from sugar alcohol, said catalyst including an H-type zeolite having an atomic composition ratio of Si to Al (Si/Al) of more than 20.


Patent
Fujikura Ltd and Hokkaido University | Date: 2017-05-24

The effective refractive indexes of core elements 10a to 10c are different from each other, and the effective refractive indexes of the core elements 10a to 10c and the effective refractive index of a second core 21 are different from each other. No core is disposed at the lattice point of a triangular lattice of a first layer LY1. First cores 11a and 11b of the core elements 10a and 10b are disposed at the lattice points of a second layer LY2. A first core 11c of the core element 10c and the second core 21 are alternately disposed at the lattice points of a third layer LY3. In a fourth layer LY4, no core is disposed at six lattice points, and the first cores 11a and 11b of the core elements 10a and 10b are disposed at the other lattice points. The second cores 21 are adjacent to the lattice points of the fourth layer LY4, at which no core is disposed. The effective refractive indexes of the core elements adjacent to each other are different from each other.


Patent
NOF Corporation and Hokkaido University | Date: 2017-06-28

An object of the present invention is to provide a cationic lipid capable of achieving higher intracellular delivery efficiency than conventional cationic lipids, when used as a lipid membrane structure which is a carrier for delivering functional nucleic acid. A cationic lipid represented by the formula (1):


Patent
Mochida Pharmaceutical Co. and Hokkaido University | Date: 2017-07-12

The present invention provides a composition for regenerating cartilage or treating a cartilage disease containing a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for regenerating cartilage that improves cartilage regenerative action and ease of application to a cartilage injury lesion, and a composition for treating a cartilage disease, which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing a cartilage injury lesion, and inhibiting inflammation and pain of joint tissue.


Patent
Fujikura Ltd and Hokkaido University | Date: 2016-02-08

A multicore fiber including two or more cores each capable of single mode transmission, a cladding covering around the two or more cores in common, and a low refractive index portion having a refractive index lower than a refractive index of the cladding, wherein a cross-section perpendicular to a longitudinal direction includes a region where two or more cores of a part or all of the two or more cores are arranged in a circular shape and at least a part of the low refractive index portion is arranged inside an inscribed circle of the cores included in the region.


Patent
Idemitsu Kosan Co. and Hokkaido University | Date: 2017-07-26

A thermosetting resin composition according to the present invention contains: purified lignin obtained by treating a herbaceous biomass as a raw material under the following conditions in a first solvent that is a mixed solvent of water and at least one type of alcohol selected from aliphatic alcohols having 4 to 8 carbon atoms, subsequently removing the alcohol from the alcohol phase that is separated at the temperature at which the first solvent separates into two phases to give lignin, adding a second solvent that is an organic solvent alone or a mixed solvent of the organic solvent and water to the resultant lignin, and removing the second solvent from the solution in which the lignin is dissolved in the second solvent; and a lignin-reactive compound that has a functional group capable of reacting with the purified lignin. Condition A: the concentration of the raw material to be charged into the mixed solvent is 1% by mass or more and 50% by mass or less. Condition B: the treatment temperature is 100C or higher and 350C or lower. Condition C: the treatment time is 0.1 hours or more and 10 hours or less.


Patent
Hokkaido University | Date: 2017-07-05

A monoclonal antibody to KIR2DS1 or a fragment containing an antigen-binding region thereof has VL having an amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having the same amino acid sequence as the amino acid sequence except that one or several amino acids are conservatively substituted as CDR1, having an amino acid sequence of SEQ ID NO: 2 or an amino acid sequence having the same amino acid sequence as the amino acid sequence except that one or several amino acids are conservatively substituted as CDR2, and having an amino acid sequence of SEQ ID NO: 3 or an amino acid sequence having the same amino acid sequence as the amino acid sequence except that one or several amino acids are conservatively substituted as CDR3; and VH having an amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 5 or an amino acid sequence having the same amino acid sequence as the amino acid sequence except that one or several amino acids are conservatively substituted as CDR1, having an amino acid sequence of SEQ ID NO: 6 or an amino acid sequence having the same amino acid sequence as the amino acid sequence except that one or several amino acids are conservatively substituted as CDR2, and having an amino acid sequence of any one selected from the group consisting of SEQ ID NO: 7, SEQ ID NO: 8, and SEQ ID NO: 9 or an amino acid sequence having the same amino acid sequence as the amino acid sequence except that one or several amino acids are conservatively substituted as CDR3.

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