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Ebetsu, Japan

Hokkaido Information University is a private university in Ebetsu, Ishikari Subprefecture, Hokkaidō, Japan. It was initially established in April 1968 with the name Hokkaido Electronics Computer School. Since 1989, Hokkaido Information University became the officially adopted name. Currently it holds international exchange agreements with Nanjing University, Shenyang Normal University in China; University of California, Santa Cruz in USA; and Rajamangala University of Technology in Thailand. Wikipedia.

Ozaki H.,Hokkaido Information University | Kara A.,University of Aizu
IEEE Transactions on Reliability | Year: 2011

In this paper, we investigate the user perceived reliability of M-for-N shared protection systems. The M-for-N shared protection system is a general type of the fault-tolerant configuration with shared backup units. We assume that there are N working units each serving a single group of users and M shared protection (spare) units in the system. We also assume that the time to failure of the unit is subject to an exponential distribution, and the time to repair it is subject to a general distribution. Under these assumptions, we derive the Laplace transform of the reliability function (The cdf of the failure time, i.e. the cumulative distribution function of the time beyond which the system will survive) for each user, as well as the user-perceived Mean Time to First Failure (MTTFF) by combining the state transition analysis and the supplementary variable method. We also show the effect of the repair time distribution of the units through the case study of the cloud computing systems in which N service-independent servers share M spares for backup purpose. The analysis reveals that there exist optimal values for M and N in terms of the reliability and the cost for the given conditions of failures and repairs. © 2006 IEEE. Source

Fukumitsu M.,Hokkaido Information University | Hasegawa S.,Tohoku University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015

In recent years, Fischlin and Fleischhacker showed the impossibility of proving the security of specific types of FS-type signatures, the signatures constructed by the Fiat-Shamir transformation, via a single-instance reduction in the non-programmable random oracle model (NPROM, for short). In this paper, we pose a question whether or not the impossibility of proving the security of any FS-type signature can be shown in the NPROM. For this question, we show that each FS-type signature cannot be proven to be secure via a key-preserving reduction in the NPROM from the security against the impersonation of the underlying identification scheme under the passive attack, as long as the identification scheme is secure against the impersonation under the active attack. We also show the security incompatibility between the discrete logarithm assumption and the security of the Schnorr signature via a singleinstance key-preserving reduction, whereas Fischlin and Fleischhacker showed that such an incompatibility cannot be proven via a non-keypreserving reduction. © Springer International Publishing Switzerland 2015. Source

Saito S.,Hokkaido Information University | Ohno K.,Chiyoda Corporation | Sakuraba H.,Meiji Pharmaceutical University
PLoS ONE | Year: 2013

Missense mutations in the α-galactosidase A (GLA) gene comprising the majority of mutations responsible for Fabry disease result in heterogeneous phenotypes ranging from the early onset severe "classic" form to the "later-onset" milder form. To elucidate the molecular basis of Fabry disease from the viewpoint of structural biology, we comprehensively examined the effects of different substitutions at the same residue in the amino acid sequence of GLA on the structural change in the enzyme molecule and the clinical phenotype by calculating the number of atoms affected and the root-mean-squaredistance value, and by coloring of the atoms influenced by the amino acid replacements. The results revealed that the severity of the structural change influences the disease progression, i.e., a small structural change tends to lead to the lateronset form and a large one to the classic form. Furthermore, the study revealed the residues important for expression of the GLA activity, i.e., residues involved in construction of the active site, a disulfide bond or a dimer. Structural study from such a viewpoint is useful for elucidating the basis of Fabry disease. © 2013 Saito et al. Source

Nishihira J.,Hokkaido Information University
Annals of the New York Academy of Sciences | Year: 2012

Macrophage migration inhibitory factor (MIF) is a unique protein that participates in inflammation, immune responses, and cell growth. An array of in vitro and in vivo experiments has demonstrated that MIF is profoundly involved in the pathogenesis of acute and chronic inflammatory disorders, such as inflammatory bowel disease (IBD). Blockade of MIF bioactivities by either neutralizing anti-MIF antibodies or antagonists prevents inflammatory cytokine cascade, which strongly suggests that an anti-MIF therapeutic strategy is feasible for treatment of IBD. Recently, we developed a new therapeutic approach for IBD by administration of antisense MIF oligonucleotides in conjugation with schizophyllan (SPG), a member of the glucan family. SPG specifically binds Dectin-1 expressed in antigen-presenting cells (APCs), and the antisense MIF/SPG complex is incorporated into the cells. In in vivo experiments of colitis models in mice, we found that intraperitoneal administration of the complex ameliorated the clinical signs of colitis and improved the histological scores. This novel therapy designed to knock down the MIF production in APCs is expected to be clinically applicable for the treatment of IBD. © 2012 New York Academy of Sciences. Source

Saito Y.,Hokkaido Information University
Proceedings - 2015 International Conference on Culture and Computing, Culture and Computing 2015 | Year: 2015

This paper presents the scatter plots representing the relative frequencies of nouns used in the texts of Japanese classical literature. These scatter plots are not designed as tools for reading the texts analytically but as visual arts. The readers will become attached to the archaic words through enjoying the illogical synergy between the literary works and the art works. © 2015 IEEE. Source

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