Hohenstein Institute

Germany

Hohenstein Institute

Germany

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Marquardt C.,Abteilung fur Allgemein und Viszeralchirurgie | Koppes P.,Abteilung fur Allgemein und Viszeralchirurgie | Krohs U.,Abteilung fur Viszeral | Mares A.,Abteilung fur Allgemeinchirurgie | And 3 more authors.
Coloproctology | Year: 2014

Results: After opening the infected wound the average wound volume was 203 ml. A débridement of the wounds was carried out to remove necrotic and sloughed tissue then the first NPWT dressing was applied. The NPWT with PHMB gauze could be changed on average every 3 days at the bedside which was possible because the pain level during each dressing change was recorded as an average of 1 on the visual analog scale (VAS). After an average of 3 NPWT dressing changes, the wounds showed no signs of infection and secondary suturing was carried out at the bedside using local anesthesia. For the first 7 patients, subcutaneously placed capillary drainage without suction was used in the wounds (group 1). As the healing rate was low (29 %) subcutaneously placed round channel drainage under suction were used for the next 9 patients (group 2) and the healing rate was 89 % after secondary suture. The average costs for NPWT treatment including labor costs were calculated as 322.20 EUR per patient.Conclusion: All procedures could be performed at the bedside and all patients were satisfied with the treatment and results. The NPWT therapy with PHMB gauze provides an economic method for lowering the total treatment time and costs as well as unnecessary usage of operating theaters.Methods: In a prospective case control study of 16 patients, the healing rate of secondary suturing of subcutaneous wound infections after median laparotomy wounds for colorectal surgery was investigated, whereby the wounds had previously been conditioned using negative pressure wound therapy (NPWT) with polyhexamethylene biguanide (PHMB) gauze. © 2014, Springer-Verlag Berlin Heidelberg.


Hammer T.R.,Hohenstein Institute | Berner-Dannenmann N.,Hohenstein Institute | Hoefer D.,Hohenstein Institute
Flavour and Fragrance Journal | Year: 2013

The retention of malodours, especially sweat on fabrics, is a widely discussed problem in the textile industry and science. Since a quantitative analysis of the retention of sweat odour molecules on fibres has not been addressed so far, we used liquid scintillation counting to measure the adhesion/dehesion of 14C-labelled isovaleric acid, a lead substance of sweat odour, to knitted fabrics of comparable textile structure made of pure cotton, wool or polyester. Significant retention differences were detected, with polyester showing the highest release of isovaleric acid after 3 h and 20 h. Fabric finishes with β-cyclodextrin enhanced odour retention on cotton and polyester considerably. To study local influences of the clothing materials on odour release, we simulated in diffusion chamber cells a fabric/human skin wear situation using an artificial skin with skin-like composition, topology and mechanical characteristics. Unidirectional transepidermal water vapour release of the skin model modulated the odour retention. Finally, all samples were subjected to a sensory evaluation test with trained panellists using olfactometry and a non-labelled artificial sweat containing isovaleric acid as lead substance. Again, polyester showed little retention capacities, whereas the cyclodextrin finish enhanced binding of the artificial sweat and thus reduced its perception. The phase II approach revealed that perceived malodour intensity clearly depended on the finish and fibre type. The presented data and methods provide a basis for future optimization of clothes in terms of sweat odour management in their respective end uses, e.g. sport or business activities. © 2013 John Wiley & Sons, Ltd.


Gerhardts A.,Hohenstein Institute | Mucha H.,Hohenstein Institute | Hofer D.,Hohenstein Institute
International Journal of Health Care Quality Assurance | Year: 2012

Purpose: Disinfecting laundry processes are essential to avoid contamination of laundering machines and linen during commercial laundry reprocessing in the health care sector. Recently a bacteriophage-charged bioindicator has been developed using MS2 as surrogate virus for testing of low-temperature disinfecting laundry processing on efficacy against viruses related to practice. This paper therefore aims to investigate application of MS2-bioindicators in chemothermal processes under practical conditions (phase 2/step 2) and in practice (phase 3). Design/methodology/approach: The experimental design was developed and modified according to the German Society for Hygiene and Microbiology (DGHM) Standard Methods for Testing Chemical Disinfection Processes. Tests under practical conditions were performed at 60°C and 70°C. Additional tests in tunnel washers were carried out at 60°C and 70°C. In all experiments validated disinfecting laundry processes, recommended for bactericidal and virucidal performance (categories A and B), were applied. Findings: The results show a temperature-dependent gradual efficacy against the test virus MS2 up to reduction values of more than 8 log 10-steps. Therefore MS2-bioindicators prove to be suitable as a tool to determine the performance of disinfection procedures against viruses in practice. Originality/value: Phage-charged bioindicators may be a tool to provide further insights into the reliability of antiviral laundry processes for health care quality management and for infection control. © Emerald Group Publishing Limited.


Sustainability has become an increasingly important topic for the players along the textile chain. Against the background of resource scarcity, we have to wonder how to handle resources and who - beside nature - generates raw materials for fiber production? Can the vision be shared that in future man-made fibers will not only be made by man, but also the raw materials for fiber production could be man-made?.


PubMed | Hohenstein Institute
Type: Journal Article | Journal: International journal of health care quality assurance | Year: 2012

Disinfecting laundry processes are essential to avoid contamination of laundering machines and linen during commercial laundry reprocessing in the health care sector. Recently a bacteriophage-charged bioindicator has been developed using MS2 as surrogate virus for testing of low-temperature disinfecting laundry processing on efficacy against viruses related to practice. This paper therefore aims to investigate application of MS2-bioindicators in chemothermal processes under practical conditions (phase 2/step 2) and in practice (phase 3).The experimental design was developed and modified according to the German Society for Hygiene and Microbiology (DGHM) Standard Methods for Testing Chemical Disinfection Processes. Tests under practical conditions were performed at 60 degrees C and 70 degrees C. Additional tests in tunnel washers were carried out at 60 degrees C and 70 degrees C. In all experiments validated disinfecting laundry processes, recommended for bactericidal and virucidal performance (categories A and B), were applied.The results show a temperature-dependent gradual efficacy against the test virus MS2 up to reduction values of more than 8 log10-steps. Therefore MS2-bioindicators prove to be suitable as a tool to determine the performance of disinfection procedures against viruses in practice.Phage-charged bioindicators may be a tool to provide further insights into the reliability of antiviral laundry processes for health care quality management and for infection control.

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