News Article | February 15, 2017
SIMI VALLEY, CA--(Marketwired - February 15, 2017) - The Ronald Reagan Presidential Foundation and Institute has announced the appointment of Gary M. Cole as the new Chief Development Officer of The Ronald Reagan Presidential Foundation and Institute. Mr. Cole will assume his new role on March 1, 2017. Dr. Cole will be responsible for executing a comprehensive and diversified fundraising plan to provide the Reagan Foundation and Institute with the continued resources it needs to promote President Reagan's legacy far into the future. "Gary will be a tremendous asset to the Foundation and Institute," said John Heubusch, executive director of the Ronald Reagan Presidential Foundation and Institute. "With his dedicated commitment to organized philanthropy and the mission of the Reagan Foundation, alongside his vast experience in public service, philanthropy and corporate affairs, we have full confidence that he will help take the Foundation's development efforts to unprecedented heights." Prior to his appointment at the Reagan Foundation and Institute, Dr. Cole served as the Managing National Director of Major Gifts and Planned Giving for the Susan G. Komen Global Headquarters, overseeing national mid-level, major, and planned giving fundraising in conjunction with Komen's 100 affiliates. Dr. Cole was also the Founder and Chief Strategist for Makau, LLC, a national fundraising consultancy with an emphasis on fundraising counsel, fan and constituent engagement, organizational development, and board and staff coaching. Dr. Cole has also held various development positions for the Cook Children's Health Foundation, the University of Texas at Arlington, the Hockaday School, the University of Texas at Dallas, the United Way of Odessa and the Catholic Diocese of Fort Worth. The Ronald Reagan Presidential Foundation is a non-profit, non-partisan organization which sustains the Ronald Reagan Presidential Library and Museum located in Simi Valley, CA , the Center for Public Affairs, the Presidential Learning Center, The Air Force One Pavilion and the new Reagan Institute located in Washington, D.C. The Reagan Library houses over 55 million pages of Gubernatorial, Presidential and personal papers and over 40,000 gifts and artifacts chronicling the lives of Ronald and Nancy Reagan. It also serves as the final resting place of President and Mrs. Reagan.
Shin Y.J.,Pusan National University |
Kim J.J.,Groton School |
Kim Y.J.,Hockaday School |
Kim W.H.,Sehwa High School |
And 8 more authors.
Journal of Medicinal Food | Year: 2015
Mercury is a well-known environmental pollutant that can cause nephropathic diseases, including acute kidney injury (AKI). Although quercetin (QC), a natural flavonoid, has been reported to have medicinal properties, its potential protective effects against mercury-induced AKI have not been evaluated. In this study, the protective effect of QC against mercury-induced AKI was investigated using biochemical parameters, new protein-based urinary biomarkers, and a histopathological approach. A 250 mg/kg dose of QC was administered orally to Sprague-Dawley male rats for 3 days before administration of mercury chloride (HgCl2). All animals were sacrificed at 24 h after HgCl2 treatment, and biomarkers associated with nephrotoxicity were measured. Our data showed that QC absolutely prevented HgCl2-induced AKI, as indicated by biochemical parameters such as blood urea nitrogen (BUN) and serum creatinine (sCr). In particular, QC markedly decreased the accumulation of Hg in the kidney. Urinary excretion of protein-based biomarkers, including clusterin, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemoattractant protein-1 (MCP-1), tissue inhibitor of metalloproteinases 1 (TIMP-1), and vascular endothelial growth factor (VEGF) in response to HgCl2 administration were significantly decreased by QC pretreatment relative to that in the HgCl2-treated group. Furthermore, urinary excretion of metallothionein and Hg were significantly elevated by QC pretreatment. Histopathological examination indicated that QC protected against HgCl2-induced proximal tubular damage in the kidney. A TUNEL assay indicated that QC pretreatment significantly reduced apoptotic cell death in the kidney. The administration of QC provided significant protective effects against mercury-induced AKI. © Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2015.
Chai W.,Southern Methodist University |
Nguyen E.,Hockaday School |
Doran J.,Southern Methodist University |
Han K.,Coppell High School |
And 7 more authors.
Tetrahedron Letters | Year: 2013
The di-tert-butyl-di-p-nitrophenyl ester of hydrazinetetracarboxylic acid was prepared and shown to be useful in the preparation of urazoles (i.e., 1,2,4-triazolidine-3,5-diones), by reaction with a primary amine using either n-BuLi or pyridine as base, depending on the desired N4 substituent. With more electronegative N4 substituents, pyridine is the preferred base. This work complements our reported urazole synthesis, which introduced the N4 substituent early in the sequence and thus did not facilitate variation at N4 for library synthesis. © 2013 Elsevier Ltd. All rights reserved.
Nguyen T.Q.,Southern Methodist University |
Chai W.,Southern Methodist University |
Gu J.,Hockaday School |
Cook K.,University of Texas at Austin |
And 11 more authors.
Tetrahedron Letters | Year: 2015
A diastereoselective process for the formation of intermediates suitable for the preparation of C1 substituted carbapenems was developed. The process is readily scalable and does not involve organometallics or strong bases such as LDA. © 2015 Elsevier Ltd.All rights reserved.
PubMed | Southern Methodist University, Western University of Health Sciences, University of Texas at Austin, Plano West Senior High School and Hockaday School
Type: Journal Article | Journal: Tetrahedron letters | Year: 2015
A diastereoselective process for the formation of intermediates suitable for the preparation of C1 substituted carbapenems was developed. The process is readily scalable and does not involve organometallics or strong bases such as LDA.
Cao J.,Southern Methodist University |
Lopez R.,Southwestern Medical Center |
Thacker J.M.,Southern Methodist University |
Moon J.Y.,Southern Methodist University |
And 6 more authors.
Chemical Science | Year: 2015
Hydrogen sulphide (H2S) is an endogenous mediator of human health and disease, but precise measurement in living cells and animals remains a considerable challenge. We report the total chemical synthesis and characterization of three 1,2-dioxetane chemiluminescent reaction-based H2S probes, CHS-1, CHS-2, and CHS-3. Upon treatment with H2S at physiological pH, these probes display instantaneous light emission that is sustained for over an hour with high selectivity against other reactive sulphur, oxygen, and nitrogen species. Analysis of the phenol/phenolate equilibrium and atomic charges has provided a generally applicable predictive model to design improved chemiluminescent probes. The utility of these chemiluminescent reagents was demonstrated by applying CHS-3 to detect cellularly generated H2S using a multi-well plate reader and to image H2S in living mice using CCD camera technology. © The Royal Society of Chemistry 2015.
PubMed | Southern Methodist University, Southwestern Medical Center and Hockaday School
Type: Journal Article | Journal: Chemical science | Year: 2015
Hydrogen sulphide (H