Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.1.2-1 | Award Amount: 5.85M | Year: 2013
Gastrointestinal stromal tumours (GIST) are a rare disease that metastasises in up to 85% of patients with subsequent median progression-free survival (PFS) of only around 30 months. Tumours are characterised by activating mutations in the KIT or the PDGFRA gene and therefore treatment is mainly based on tyrosine kinase inhibitors designed to block these mutated receptors. However, drug resistance is often based on mutations changing the conformity of the receptor, leaving little effective therapeutic options to these patients. To date, second line chemotherapy offers a median PFS of 6-9 months and external beam radiotherapy is limited by organs at risk close to the tumour. Alternative approaches such as endoradiotherapy or minimally-invasive ablation techniques are effective for local control but are inconsistently used and are not tailored to the individual patients type of disease. To address these issues, we propose a closed-loop personalised treatment concept combining endoscopic-assisted tissue sampling, inline biotechnology and targeted molecular PET imaging probe development combined with minimally-invasive treatment monitored by new functional and metabolic MR imaging techniques. A consistent value chain across European academic centres, research institutes and SMEs will be established for mass spectrometry of tumours, linkage of radiochemical molecular imaging probes, design of new immunocompromised animal models and targeted therapeutic radiopharmaceuticals. This closed-loop platform will minimise fragmentation of treatment approaches by a coherent molecular-based multimodality concept, thus providing new treatment options. On a larger scale, the MITIGATE platform can be expanded to further patient cohorts with oligometastatic diseases such as other sarcomas or renal cell carcinoma. For SMEs the access to new animal models and ligands along with translation into clinical practice will strengthen their market share for new probes and imaging technology.
Ottenbacher M.,BASF |
Olujic Z.,Technical University of Delft |
Adrian T.,Hochschule Mannheim |
Jodecke M.,BASF |
Chemical Engineering Research and Design | Year: 2011
Distillation is the most important thermal separation process, with separation efficiency as one of the fundamental parameters to influence economy and energy consumption. The precise knowledge of separation efficiency and the ability to compare different types of column internals is vital information for the chemical industry. Still, total reflux distillation experiments are the only significant source of such data. The authors have taken the effort to work out in elaborate manner different factors influencing both measurement and interpretation of structured packing separation efficiency data, to provide basis for establishing an open standard in this respect. In addition, an improved set of thermophysical correlations for the test system chlorobenzene/ethylbenzene (CB/EB) is presented. © 2011 The Institution of Chemical Engineers.
Hengen S.,Hochschule Mannheim |
Hengen S.,The InnovationLAB |
Hengen S.,Karlsruhe Institute of Technology |
Alt M.,The InnovationLAB |
And 10 more authors.
Organic Electronics: physics, materials, applications | Year: 2014
This paper presents a model for the simulation of gate leakage currents within organic thin film transistors. These unintended currents act as loads within integrated electronic circuits and thereby can have a huge impact on its functionality. Simulation of these currents is important in order to design and manufacture high performance organic electronics circuits of high complexity. We show the influence of gate leakage currents on signals within a circuit. A model for electrical simulations is developed, which is based on defects within the dielectric layer. Only two new parameters need to be determined, they describe the size and amount of defects. The improvement of simulation by this model is verified by comparison of measurements and simulations. © 2013 Elsevier B.V. All rights reserved.
Graser B.,German Cancer Research Center |
Al-Maisary S.,Universitatsklinikum Heidelberg |
Zimmermann N.,Universitatsklinikum Heidelberg |
Nabers D.,German Cancer Research Center |
And 4 more authors.
Zeitschrift fur Herz-, Thorax- und Gefasschirurgie | Year: 2014
Background: Current methods to determine the size of an annuloplasty ring for mitral valve reconstruction are semi-quantitative and dependent on the subjective assessment by the surgeon which requires a high degree of professional experience.Aim: Computer-assisted ring sizing supports the surgeon with a quantitative measurement tool for an objective ring selection.Material and methods: A fast modeling method for the annulus of the mitral valve was developed, which is easy to integrate into the clinical workflow. It enables precise measurement and preoperative deformation analysis of annuloplasty rings. Additionally, ring implants can be created based on the patient’s individual anatomy.Results: Computer-assisted modeling and measurement tools enable an objective and reproducible ring selection. The possibility of manufacturing patient-specific designed rings can lead to a novel patient-centered treatment. © 2014, Springer-Verlag Berlin Heidelberg.
Pashkova A.,Dechema Institute |
Greiner L.,Hochschule Mannheim |
Krtschil U.,Fraunhofer Institute of Microtechnology Mainz |
Hofmann C.,Fraunhofer Institute of Microtechnology Mainz |
Zapf R.,Fraunhofer Institute of Microtechnology Mainz
Applied Catalysis A: General | Year: 2013
An approach for the direct synthesis of hydrogen peroxide with CO 2 as solvent has been explored. Both batch and continuous experiments have been performed. The activity of self-prepared Pd-supported catalysts has been verified leading to high productivity of up to 132 gH2O2 gPd-1 h-1 in batch with selectivities of up to 70%. However, the use of dense CO2 in batch set back catalyst activity leading to the formation of H2O as the only product. For the continuous process in dense CO2 increased performance in terms of productivity with up to 26 gH2O2 gPd-1 h-1 with low selectivity were achieved. © 2013 Elsevier B.V. All rights reserved.
Wagner K.,Max Planck Institute for Astronomy |
Alter M.,Max Planck Institute for Astronomy |
Bideaux A.,Hochschule Mannheim |
Klein R.,Max Planck Institute for Astronomy |
And 3 more authors.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2010
With steadily increasing telescope sizes and the growing complexity of scientific instruments, there is an ever-growing demand for improved electronics, controlling all the different optical parts on moving mechanisms. Among competing requirements are, on one hand, the increasing number of actuators, with high-precision positioning in closed and open loop, and on the other hand, smaller sizes, low power and restricted heat emission. A specific challenge is accommodating mechanisms that operate in infrared instrumentation at cryogenic temperatures down to 60 Kelvin. In this area piezo motors offer promising solutions. To fulfill these different demands a competitive motion control system has been developed at the Max-Planck-Institut für Astronomie (MPIA) in Heidelberg, Germany. A modular chassis with standardized boards provides best solutions for extensive tasks. High and low power DC servo motors, brushless DC servo motors, stepper motors and piezo motors with different technologies are supported. Diversity position feedback capabilities, like incremental and absolute encoders for non cryogenic and capacitive sensors and resolvers for cryogenic applications, are provided. © 2010 Copyright SPIE - The International Society for Optical Engineering.
Tilsner M.,Memorial University of Newfoundland |
Fiech A.,Memorial University of Newfoundland |
Zhan G.,Memorial University of Newfoundland |
Specht T.,Hochschule Mannheim
ACM International Conference Proceeding Series | Year: 2011
The discovery of suitable services is a crucial, but challenging activity during service-oriented engineering. While in many scenarios a single service will satisfy the user's exigent needs, there are cases where a combination of services might be appropriate. In this work-in-progess paper we identify several composition patterns that assist in the discovery of appropriate services. We outline a pattern based algorithm for service discovery and formalize the solution set. © 2011 ACM.
Enger M.,Slovak University of Technology in Bratislava |
Blaskovits P.,Slovak University of Technology in Bratislava |
Feinle P.,Hochschule Mannheim
Tribologie und Schmierungstechnik | Year: 2013
Within this work different slide-active coatings for thermoplastics, based on a new binder technology, were investigated for their use in the automobile interior. These coatings were slide-modified with typical solid lubricants (h-BN, PTFE, graphite) at different concentrations. The main focus of this paper is the determination of the sliding behaviour of the coated thermoplastics in direct comparison to the uncoated variants. The coatings showed clearly different slide motion properties concerning their friction coefficient and stick-slip behaviour. In a direct comparison with the currently used polymers a clear improvement of slide properties could be achieved.
Enger M.,Hochschule Mannheim |
Weissling F.,Hochschule Mannheim |
Feinle P.,Hochschule Mannheim
Tribologie und Schmierungstechnik | Year: 2010
Within this work different slide modified coatings for thermoplastics, based on a new binder technology, were investigated for their use in the automobile interior. These coatings were slide-modified with typical solid lubricants (h-BN, PTFE, graphite) at different concentrations. Stick slip properties of the different coating systems as well as the friction properties under oscillating slide motion at different parameters were investigated. The coatings showed clearly different slide motion properties concerning their friction coefficient and stick slip. In a direct comparison with currently used polymers a clear improvement of slide properties could be achieved.