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Hannover, Germany

The control of mastitis in herds affected by cow-associated microorganisms should be based on prophylactic means to reduce the new infection rate. In the cases of Streptococcus (Sc.) agalactiae and Sc. canis, control is aimed towards eradication of these pathogens on herd level, while the prevalence and, with that, the new infection by Staphylococcus (S.) aureus should be lowered to a minimum. When dealing with infections by S. aureus on herd level, usually extensive culling of infected animals and therapies to eliminate existing infections may be avoided, as long as the measures to control new infections are set into practice thoroughly. Of those, the most important ones are identifying infected animals, separating them from the uninfected ones, observing a corresponding hygiene at milking, disinfecting the teats after milking with accredited products and disinfecting clusters between milking. Except for surveys after appliance, no studies regarding the efficiency of S. aureus vaccines have been performed so far. When dealing with herd problems due to Sc. agalactiae, a similar approach as with S. aureus in order to reduce the new infection rate is recommended. However, this pathogen spreads more quickly than the other one, and so it is essential to reduce the control phase to a minimum. So, after identifying infected animals, a decision for therapy or culling must be made subsequently. If therapy fails, animals should leave the farm at once. © M. & H. Schaper GmbH & Co.

Wolff M.,Leibniz University of Hanover | Kruger C.,Leibniz University of Hanover | Homenya P.,Leibniz University of Hanover | Heyer L.,Leibniz University of Hanover | And 9 more authors.
Hyperfine Interactions | Year: 2014

Mononuclear iron complexes in which the iron(III) ion is coordinated by a pentadentate Schiff base ligand L5 with two phenolate, two imino and one amino group can exhibit a spin crossover. In this contribution experimental results are presented for complexes with cyanate and thiocyanate as co-ligands. Furthermore, theoretical results of quantum chemical calculations of energies and entropies for the low-spin and high-spin state are shown and compared with Mössbauer results. We also demonstrate how the ligand field of the monodentate co-ligand influences the spin crossover energies and entropies in [FeIIIL5NCY] complexes. © 2013 Springer Science+Business Media Dordrecht.

In vehicle applications, brushless dc drives (BLDC drives) are commonly used as auxiliary drives, if enhanced operating life time is required. For these drives permanent magnet synchronous machines are used. The local flux density curves in the iron parts of the stator of these machines are not sinusoidal. Beside unidirectional magnetization, also elliptical magnetization occurs in general. This requires a determination of iron losses for general elliptical magnetization. This paper describes a method based on the loss data for unidirectional magnetization. The results are compared to measurements. © 2015, Springer Verlag Wien.

Beygui F.,French Institute of Health and Medical Research | Silvain J.,French Institute of Health and Medical Research | Pena A.,French Institute of Health and Medical Research | Bellemain-Appaix A.,French Institute of Health and Medical Research | And 5 more authors.
American Journal of Cardiology | Year: 2010

We sought to assess whether multiple biomarkers would correlate with the outcome and could improve event prediction in nonST-segment elevation acute coronary syndrome populations with low event rates. Nine inflammatory, ischemic, or neurohormonal biomarkers were measured within 48 hours after symptom onset in 440 patients with nonST-segment elevation acute coronary syndrome from the ARCHIPELAGO (Irbesartan in Patients With Acute Coronary Syndrome Without ST Segment Elevation) trial. We assessed the relation between biomarkers and ischemic or heart failure composite end points at 2 months of follow-up. We also evaluated whether biomarkers could improve the predictive performance of the validated and well-performing Global Registry of Acute Coronary Events risk score. Among all biomarkers measured at baseline, only interleukin-6 correlated with the ischemic end point (adjusted odds ratio 1.69, 95% confidence interval [CI] 1.23 to 2.31). The independent correlates of the heart failure end point were B-type natriuretic peptide (adjusted odds ratio 3.16, 95% CI 1.99 to 5.03), aldosterone (adjusted odds ratio 1.57, 95% CI 1.14 to 2.16) and matrix metalloproteinase-9 (adjusted odds ratio 0.64, 95% CI 0.46 to 0.88). The Global Registry of Acute Coronary Events score predicted poorly the ischemic end point (area under the curve [AUC] 0.591) and fairly (AUC 0.775) the heart failure end point. The performance of the models was significantly improved by the introduction of interleukin-6 (AUC 0.685) for the ischemic end point and of the 3 biomarkers (AUC 0.874) for the heart failure end point. In conclusion, the interleukin-6 level only, and B-type natriuretic peptide, aldosterone, and matrix metalloproteinase-9 together, independently correlated with the ischemic and heart failure end points, respectively. The Global Registry of Acute Coronary Events risk score's performance was significantly improved with a biomarker strategy. In low-risk populations, a strategy using these biomarkers might help in identifying patients at greater risk of additional events. © 2010 Elsevier Inc. All rights reserved.

Agency: Cordis | Branch: FP7 | Program: BSG-SME | Phase: SME-2013-1 | Award Amount: 1.50M | Year: 2013

Initial situation: The operation of small power plants (e.g. for households) for electricity, heat and cold (micro trigeneration) requires new solution trials. There are systems required, which are user-friendly, low-maintenance, economic. The new Schukey engine unites provide these attributes. The Schukey engine shows an ingenious concept (universality as a concept) and works at a temperature of 120C steam or 1.1 bar. The cooling is directly made by air. In the Central Europe 5 kWel and 20 kWth are provided to 40 m CPC-collectors. A household can cover of the annual heat demand (approx. 27 MWh) and current demand (approx. 4 MWh). Difficulties: The Schukey technology is deciding in a very early developmental stage and thus it still requires a comprehensive development work: (1) Transmission compression, (2) Mass diminution (rotors & case), (3) coordination the control of the pressure volume temperature on the optimal expansion relationship of the domestic operating range, (4) creation of a thick system despite a smaller performance (max. 3% mass loss), (5) Integration into the primary domestic energy system or power supply system. Aims: 1. The priority aim of the project is the development and test application of a compact combination plan (10 kg of engine weight for 5 kWel) for a production of current, heat and cold in the smaller performance are by using of the Schukey technology short microsolar trigeneration. 2. It should be directed a simple, standardized, economic and suitable for practices solution (for a Schukey engine should be obtained a performance area of 2-2.5kWel and a pure engine manufacturing between 300 and 500 ). 3. The project should aim for that specific current prime costs, which be directed in the area of the net parity (these should be long running). The cold of use should be provided by approx.0.5 /kWh (conventional air conditioners: 0,12 /kWh).

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