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Taizhou, China

Ning C.-Q.,Central South University | Lu C.,Central South University | Hu L.,Central South University | Bi Y.-J.,Central South University | And 6 more authors.
European Journal of Medicinal Chemistry | Year: 2015

A novel series of macrocyclic compounds were designed and synthesized as multi-target inhibitors targeting HDAC, FLT3 and JAK2. Some of these compounds exhibited potent HDAC inhibition as well as FLT3 and JAK2 inhibition under both cell-free and cellular conditions. In vitro antiproliferative assay indicated that these compounds were interestingly more cytotoxic to MV4-11 cells bearing FLT3-ITD mutation and HEL cells bearing JAK2V617F mutation. © 2015 Elsevier Masson SAS. All rights reserved. Source


Ning C.,Central South University | Bi Y.,Central South University | He Y.,Central South University | Huang W.,Central South University | And 6 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2013

A novel class of di-substituted cinnamic hydroxamic acid derivatives containing urea or thiourea unit was designed, synthesized and evaluated as HDAC inhibitors. All tested compounds demonstrated significant HDAC inhibitory activities and anti-proliferative effects against diverse human tumor cell lines. Among them, 7l exhibited most potent pan-HDAC inhibitory activity, with an IC50 value of 130 nM. It also showed strong cellular inhibition against diverse cell lines including HCT-116, MCF-7, MDB-MB-435 and NCI-460, with GI50 values of 0.35, 0.22, 0.51 and 0.48 μM, respectively. © 2013 Elsevier Ltd. All rights reserved. Source


Ning C.,Central South University | Huang W.,Central South University | Wu W.,Central South University | Lu C.,Central South University | And 10 more authors.
Letters in Drug Design and Discovery | Year: 2015

A series of di-substituted cinnamic hydroxamic derivatives was designed, synthesized and evaluated as HDAC inhibitors. Compound 5f (HS270) demonstrated potent HDAC inhibitory and antiproliferative activities. In xenograft model, 5f showed significant antitumor efficacy in tumorbearing mice. © 2015 Bentham Science Publishers. Source

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