Liu S.-G.,Qingdao University |
Li Y.-Y.,Qingdao University |
Sun R.-X.,Qingdao University |
Wang J.-L.,Qingdao University |
And 4 more authors.
Rheumatology International | Year: 2015
Previous studies have showed that patients with gout showed lower serum 25(OH)D levels. As the specific receptor of vitamin D, VDR plays an important role in regulating immune system by combining with vitamin D. In this study, we investigated whether the functional VDR polymorphisms were associated with susceptibility to gout in Chinese Han male population. A total of 504 patients with gout and 523 gout-free controls were recruited from the Affiliated Hospital of the Medical College, Qingdao University. Genotyping of VDR rs11568820, rs2228570 and rs1544410 was performed by TaqMan allele discrimination assays. An association analysis was carried out using the χ2 test. A genotype–phenotype analysis was also conducted. Our results showed that polymorphisms of rs11568820 and rs1544410 in VDR were associated with gout in Chinese Han male population. The A allele of both rs11568820 and rs1544410 was associated with the risk of gout [P = 0.012 OR 1.251, 95 % CI (1.051–1.490); P = 0.006, OR 1.574, 95 % CI (1.139–2.175)]. However, there was no statistic significance between rs2228570 and gout (P = 0.186). Our study suggested that the polymorphisms of VDR may be relevant host susceptibility factors for the development of gout in Chinese Han male population. However, further study should be done in a larger size sample and other ethic to test and verify our result. © 2014, Springer-Verlag Berlin Heidelberg.
Wu Q.-C.,Hiser Hospital |
Wang Z.-H.,Hiser Hospital |
Han B.,Hiser Hospital |
Fan C.-H.,Hiser Hospital |
And 3 more authors.
Journal of Leukemia and Lymphoma | Year: 2010
Objective To explore the incidence,clinical and neuroimaging features, possible risk factors and outcome of central nervous system (CNS) complications one year after hapilo-matched non-ablative hematopoietic stem cells transplantation. Methods The medical records of 36 consecutive patients who underwent hapilo-matched non-ablative hematopoietic stem cells transplantation for malignant and nonmalignant hematologic diseases between February 2004 and May 2009 were reviewed. Results CNS complications occurred in six (16.7%) patients. Four of the six patients (66.7%) died. Cerebral infarction occurred in three (8.3%) patients. Cerebral softenness occurred in two (5.6%) patients. Cerebral hemarrage occurred in 1 (2.8%) patient. Epilepsy occurred in 1 (2.8%) patient. The CNS complications occurred between 12 days and 286 days after stem cells transplantationB The age illness status and death rate were statistically different compared to patients without CNS complications (P <0.05). Conclusion The incidence and mortality of CNS complications are higher in those who underwent hapilo-matched non-ablative hematopoietic stem cells transplantation,which will make impacts on the patients' life quality and outcome. The illness status and eldly are probably the risk factors.