Hiroshima Prefectura Hospital

Hiroshima-shi, Japan

Hiroshima Prefectura Hospital

Hiroshima-shi, Japan
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Ohba H.,Hiroshima University | Yamaguchi S.,Hiroshima University | Magari T.,Hiroshima Prefectura Hospital | Takeda M.,Hiroshima University | And 3 more authors.
Hiroshima Journal of Medical Sciences | Year: 2017

Hemangioblastoma disseminated along leptomeninges from the solitary cranial lesion without von Hippel-Lindau (VHL) disease is a quite rare instance with 23 cases reported in 40 years. We add a new case and discuss these rare instances. A 55-year-old female underwent surgery for total removal of cerebellar hemangioblastoma. Twenty months later, magnetic resonance (MR) images of the spinal cord revealed a tumor compressing the thoracic cord at T3-4 level which was removed en bloc by emergent spinal surgery. However, paraplegia and bowel bladder dysfunction recurred 5 months after the spinal surgery. Spine MR images showed diffuse enhancement of subarachnoid space. Exploratory surgery disclosed that the enhanced lesion was disseminated hemangioblastoma. After whole spinal irradiation, she was transferred to a palliative care hospital. Even after complete removal, possibility of leptomeningeal dissemination demands continuous follow-up. The mechanism of seeding of hemangioblastoma remains unclear, but attention must be paid to avoid spreading tumor cells during surgery because all the disseminated cases had precedent cranial surgery.


Akimoto E.,Hiroshima Prefectura Hospital | Ohara M.,Hiroshima Prefectura Hospital | Noma M.,Hiroshima Prefectura Hospital | Kamitsuna M.,Hiroshima Prefectura Hospital | And 2 more authors.
Japanese Journal of Cancer and Chemotherapy | Year: 2013

The patient was a 62-year-old woman who had undergone modified radical mastectomy for right breast cancer 19 years before. She was examined at our hospital for cough and hoarseness. After PET-CT and bronchoscopy, she was diagnosed with stage IIIB non-small cell lung cancer. Radiation therapy and cisplatin plus pemetrexed therapy were effective, and she made a recovery from a life-threatening conditon. During observation, a skin nodule was noticed on her right chest wall, and excisional biopsy revealed a skin metastasis from breast cancer. A transbronchial lung biopsy (TBLB) specimen was reexamined, and the lung lesion was shown to be metastasis from breast cancer. By changing to endocrine therapy, the disease has been effectively controlled.

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