Ehara A.,Hiroshima International University
Tohoku Journal of Experimental Medicine | Year: 2017
Infants and toddlers are prone to rapidly contracting illnesses, which are usually attributed to infectious diseases. Most nurseries and schools in Japan, however, refuse to accept children even with mild illnesses. For working parents, a sick child may therefore create new problems as the situation requires new day-care arrangements. To support such families, the Japanese government subsidizes construction and management of nurseries that operate especially for sick children. However, it has not been known whether most families are able to access such nurseries. To clarify the accessibility of these services, I calculated the distance to the nurseries from each of the 211,012 “blocks” (small residential areas with a median of 0.18 km2) in Japan and determined the proportion of children aged 0-4 years who lived within 3, 5, 10, 20 or 30 km of the nearest such nursery. Overall, 82.1% of these children lived within 10 km. However, the proportion was lower in northern parts of Japan such as Hokkaido and Tohoku, which have expansive land areas and low population and pediatric department densities. The proportion of children who lived within that same distance of the nearest nursery was also much lower in small towns and villages with 10,000 or fewer residents. Nurseries for sick children were not evenly distributed, and children and their caregivers in under-populated areas had to travel further to access these facilities. As the national government subsidizes such services, children and caregivers throughout Japan should have equal access to them. © 2017 Tohoku University Medical Press.
News Article | June 19, 2017
HIROSHIMA, Japan--(BUSINESS WIRE)--Hiroshima International University, a university specializing in health, medical care, and public welfare, has released a concept video entitled "Cheatable Exam?" The video depicts its unique take on exam-taking. An exam begins in a classroom at the university. An exam monitor gives the signal, and students delve into the test. Soon after, one of the students begins to notice that others around him are starting to whisper in each other's ear. That is not all. Some students are using the light on their smartphone to send Morse code; others are communicating across the room in sign language; and there are even paper airplanes flying about. It is obvious that this class has fallen into a cheating free-for-all! Despite all of this activity, the exam monitor does not seem agitated, whatsoever. Finally, the students stand up, and then... This concept video depicts the actual events in a practical IPE course conducted at Hiroshima International University. Modern times abound with "questions that do not have clear-cut answers." To respond to such societal changes, "active learning" has been rising in popularity in academic settings. In contrast to one-sided discourses, this type of learning encourages students take the initiative to solve problems on their own. With this backdrop, the video communicates the thrill of working together to brainstorm innovative solutions to questions that have no definitive answer, and also the joy of facing challenges together with others. What is this―a cheating free-for-all!? The scene that at first glance appears to be students cheating turns out to be students from a variety of disciplines―such as medical technology, nursing, medicine, psychology, and rehabilitation―working as one to solve a problem. This embodies the practices of IPE (interprofessional education), which has been drawing significant attention in recent years. Out in the field, health care has seen a surge of cases that cannot be treated with the specialized knowledge of any single specific discipline, but rather require collective intelligence and collaboration across a diverse range of fields. The video is designed to question the preconceived notion that tests must be solved individually, and introduces the IPE approach advocated by the university, which empowers students to think without restrictions and utilize each person's expertise to derive solutions. The concept of IPE has already been ingrained at Hiroshima International University, which has been implementing educational programs each year with integrated teams of some 1000 members composed of every discipline―from emergency care to diagnostic radiology, clinical engineering, clinical management, psychology, and more. An "IPE Camp" has also been incorporated into the curriculum. Here, students from each discipline visit each other's practical training facilities where they strive to better understand other fields and engage in learning that connects with real problems occurring in the real world of health care today. Josho Gakuen Hiroshima International University was established in April 1998 Specializing in health, medical care, and public welfare, the university is now home to 8 faculties and 10 departments, which deliver education to approximately 4,200 students. The university will celebrate its 20th anniversary in 2018. "For the world, for people, and for the region," the University is committed to continuing its journey hand-in-hand with people with a dedication to cultivate highly-trained specialists that practice medicine with compassion. http://www.hirokoku-u.ac.jp/english/index.html
Kitamura S.,Nihon Pharmaceutical University |
Sugihara K.,Hiroshima International University
Xenobiotica | Year: 2014
1. Human-chimeric mice with humanized liver have been constructed by transplantation of human hepatocytes into several types of mice having genetic modifications that injure endogenous liver cells. Here, we focus on liver urokinase-type plasminogen activator-transgenic severe combined immunodeficiency (uPA/SCID) mice, which are the most widely used human-chimeric mice. Studies so far indicate that drug metabolism, drug transport, pharmacological effects and toxicological action in these mice are broadly similar to those in humans. 2. Expression of various drug-metabolizing enzymes is known to be different between humans and rodents. However, the expression pattern of cytochrome P450, aldehyde oxidase and phase II enzymes in the liver of human-chimeric mice resembles that in humans, not that in the host mice. 3. Metabolism of various drugs, including S-warfarin, zaleplon, ibuprofen, naproxen, coumarin, troglitazone and midazolam, in human-chimeric mice is mediated by human drug-metabolizing enzymes, not by host mouse enzymes, and thus resembles that in humans. 4. Pharmacological and toxicological effects of various drugs in human-chimeric mice are also similar to those in humans. 5. The current consensus is that chimeric mice with humanized liver are useful to predict drug metabolism catalyzed by cytochrome P450, aldehyde oxidase and phase II enzymes in humans in vivo and in vitro. Some remaining issues are discussed in this review. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.
Hishimura Y.,Hiroshima International University
Behavioural Processes | Year: 2015
The present study examines the effect of interaction with a conspecific on conditioned taste aversion in 32 male mice. Subjects were injected with lithium chloride immediately after drinking saccharin solution for 30. min. They were then exposed to a male conspecific for 3. h following the poisoning. In the subsequent three consecutive days of two-bottle tests involving a choice between saccharin solution and water, they showed attenuated conditioned taste aversion compared with controls exposed to no conspecific after poisoning. These results confirm social interaction with a conspecific reduces conditioned taste aversion in mice. The implications of these findings are discussed with regard to social buffering effect and stress-induced analgesia. © 2014 Elsevier B.V.
Abe T.,Health Sciences University of Hokkaido |
Ikeda T.,Health Sciences University of Hokkaido |
Yanada R.,Hiroshima International University |
Ishikura M.,Health Sciences University of Hokkaido
Organic Letters | Year: 2011
The concise total synthesis of calothrixins A and B has been accomplished by utilizing the one-pot formation of hexatriene as a key intermediate via the palladium-catalyzed tandem cyclization/cross-coupling reaction of triethyl(indol-2-yl)borate. In another key transformation, the indolo[3,2-j]phenanthridine core was prepared in high yield via Cu(I)-mediated 6π-electrocyclization. © 2011 American Chemical Society.
Sueda T.,Hiroshima International University |
Oshima A.,Hiroshima International University |
Teno N.,Hiroshima International University
Organic Letters | Year: 2011
This study describes the first reliable synthesis of N-alkynyl imides (ynimides). This was accomplished with a copper-catalyzed coupling reaction between alkynyl(triaryl)bismuthonium salts and five-membered imides. We also found that it was possible to utilize N-ethynyl phthalimide as a variant of the highly labile ethynamine. 4-Amino-1,2,3-triazole was successfully obtained via the CuAAC reaction of N-ethynyl phthalimide with azide followed by hydrazinolysis of the phthaloyl protecting group. © 2011 American Chemical Society.
Takeda S.,Hiroshima International University
Biological and Pharmaceutical Bulletin | Year: 2014
Δ9-Tetrahydrocannabinol (Δ9-THC), a biologically active constituent of marijuana, possesses a wide variety of pharmacological and toxicological effects (e.g., analgesia, hypotension, reduction of inflammation, and anti-cancer effects). Among Δ9-THC's biological activities, its recognized anti-estrogenic activity has been the subject of investigations. Since Δ9-THC is used as both a drug of abuse (marijuana) and as a preventive therapeutic to treat pain and nausea in cancer patients undergoing chemotherapy in the United States and other countries (synthesized Δ9-THC; dronabinol), it is important to investigate the mechanistic basis underlying the anti-estrogenic activity of Δ9-THC. Since Δ9-THC has "no" binding potential for estrogen receptor α (ERα) which can be activated by estrogen (E2), the question of how Δ9-THC exerts its inhibitory effect on ERα is not resolved. We have recently reported that ERβ, a second type of ER, is involved in the Δ9-THC abrogation of E2/ERα-mediated transcriptional activity. Here we discuss the possible mechanism(s) of the Δ9-THC-mediated disruption of E2/ERα signaling by presenting our recent findings as well. © 2014 The Pharmaceutical Society of Japan.
Shimizu R.,Hiroshima International University
Biological and Pharmaceutical Bulletin | Year: 2014
Many synthetic chemicals have been identified as environmental contaminants with activity to disrupt normal function of the thyroid hormone system. Thyroid hormones play important roles in growth, development, differentiation, and basal metabolic homeostasis, as well as in brain development in human fetus and children, and thyroid dysfunction can have very serious consequences, including mental retardation. Environmental chemicals may affect thyroid hormone action in multiple ways, including reduced thyroid hormone synthesis owing to direct toxicity at the thyroid gland, interaction with thyroid hormone receptors and transporters such as transthyretin, and disturbance of thyroid hormone metabolism (e.g., glucuronidation, sulfation and deiodination). In addition, iodotyrosine deiodinase, which is involved in iodide salvage by catalyzing deiodination of iodinated by-products of thyroid hormone production, was recently identified as a possible new target for disruption of thyroid hormone homeostasis by environmental halogenated chemicals. This topic, after briefly summarizing findings on the thyroid hormone-disrupting action of environmental chemicals in mammals, focuses on the effects of environmental halogenated chemicals on iodotyrosine deio-dinase activity. © 2014 The Pharmaceutical Society of Japan.
Okamoto N.,Hiroshima International University |
Ishikura M.,Health Sciences University of Hokkaido |
Yanada R.,Hiroshima International University
Organic Letters | Year: 2013
A new cleavage reaction of carbon-carbon triple bonds proceeds efficiently with NIS and TMSN3, giving the corresponding nitriles in moderate to good yields. © 2013 American Chemical Society.
Ehara A.,Hiroshima International University
Pediatrics International | Year: 2013
Background According to the Japan Pediatric Society, the mean extra work hours of hospital pediatricians in 2010 was approximately 80 h per month, which is the certification criterion for Karoshi (death from overwork), but there is no precise picture of personnel management at hospitals because the labor authorities do not disclose detailed statistics concerning labor law violations to the public. Methods Most local governments have a disclosure system, and the local governments that operate public hospitals were requested to disclose warning documents issued by the labor authorities from March 2002 to March 2011. Results A total of 208/369 public hospitals (56.4%) with ≥200 beds in Japan were warned of labor law violations. Offenses included exceeding the limit of working hours (177 hospitals) and non-payment of increased wages for night and holiday work (98 hospitals). Conclusions Many public hospitals in Japan did not always pay workers including physicians for increased workload because they do not regard night and holiday duties as work hours. © 2012 The Authors.