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Morimoto H.,Hiroshima International University | Shimada H.,Waseda University
International Journal of Stress Management | Year: 2015

The purpose of this study was to examine whether the relationship between psychological distress and coping strategies that consider sociocultural beliefs about coping differs depending on the types of coping strategies and the motivation behind their choice. We considered the sociocultural beliefs about coping to be equivalent to the individual's appraisal of the group's acceptance of their coping strategy (i.e., appraisal of coping acceptability). Japanese employees (n = 737; 536 male and 201 female individuals; mean age 38.8 years, SD = 11.0) of an information technology company participated in the study. The results showed that, regardless of the type of coping strategy (i.e., problem-focused, emotion-focused, or avoidant coping), greater use of coping strategies presumed to be in line with sociocultural beliefs was related to lower psychological distress for task stressors, whereas greater use of problem-focused coping presumed to be in line with sociocultural beliefs was related to lower psychological distress for interpersonal stressors. The motivation for employing the chosen coping strategy was significantly related to psychological distress for task stressors, but not for interpersonal stressors. Although there were some significant interactions between the use of coping strategies, presumed being in line with sociocultural beliefs, and the motivation behind that choice, the interaction effect was small. These results suggest that the motivation for using a chosen coping strategy can affect the effectiveness of coping strategies, independent from the selective use of coping strategies made in consideration of sociocultural beliefs. © 2015 American Psychological Association. Source

Hishimura Y.,Hiroshima International University
Behavioural Processes | Year: 2015

The present study examines the effect of interaction with a conspecific on conditioned taste aversion in 32 male mice. Subjects were injected with lithium chloride immediately after drinking saccharin solution for 30. min. They were then exposed to a male conspecific for 3. h following the poisoning. In the subsequent three consecutive days of two-bottle tests involving a choice between saccharin solution and water, they showed attenuated conditioned taste aversion compared with controls exposed to no conspecific after poisoning. These results confirm social interaction with a conspecific reduces conditioned taste aversion in mice. The implications of these findings are discussed with regard to social buffering effect and stress-induced analgesia. © 2014 Elsevier B.V. Source

Abe T.,Health Sciences University of Hokkaido | Ikeda T.,Health Sciences University of Hokkaido | Yanada R.,Hiroshima International University | Ishikura M.,Health Sciences University of Hokkaido
Organic Letters | Year: 2011

The concise total synthesis of calothrixins A and B has been accomplished by utilizing the one-pot formation of hexatriene as a key intermediate via the palladium-catalyzed tandem cyclization/cross-coupling reaction of triethyl(indol-2-yl)borate. In another key transformation, the indolo[3,2-j]phenanthridine core was prepared in high yield via Cu(I)-mediated 6π-electrocyclization. © 2011 American Chemical Society. Source

Shimizu R.,Hiroshima International University
Biological and Pharmaceutical Bulletin | Year: 2014

Many synthetic chemicals have been identified as environmental contaminants with activity to disrupt normal function of the thyroid hormone system. Thyroid hormones play important roles in growth, development, differentiation, and basal metabolic homeostasis, as well as in brain development in human fetus and children, and thyroid dysfunction can have very serious consequences, including mental retardation. Environmental chemicals may affect thyroid hormone action in multiple ways, including reduced thyroid hormone synthesis owing to direct toxicity at the thyroid gland, interaction with thyroid hormone receptors and transporters such as transthyretin, and disturbance of thyroid hormone metabolism (e.g., glucuronidation, sulfation and deiodination). In addition, iodotyrosine deiodinase, which is involved in iodide salvage by catalyzing deiodination of iodinated by-products of thyroid hormone production, was recently identified as a possible new target for disruption of thyroid hormone homeostasis by environmental halogenated chemicals. This topic, after briefly summarizing findings on the thyroid hormone-disrupting action of environmental chemicals in mammals, focuses on the effects of environmental halogenated chemicals on iodotyrosine deio-dinase activity. © 2014 The Pharmaceutical Society of Japan. Source

Takeda S.,Hiroshima International University
Biological and Pharmaceutical Bulletin | Year: 2014

Δ9-Tetrahydrocannabinol (Δ9-THC), a biologically active constituent of marijuana, possesses a wide variety of pharmacological and toxicological effects (e.g., analgesia, hypotension, reduction of inflammation, and anti-cancer effects). Among Δ9-THC's biological activities, its recognized anti-estrogenic activity has been the subject of investigations. Since Δ9-THC is used as both a drug of abuse (marijuana) and as a preventive therapeutic to treat pain and nausea in cancer patients undergoing chemotherapy in the United States and other countries (synthesized Δ9-THC; dronabinol), it is important to investigate the mechanistic basis underlying the anti-estrogenic activity of Δ9-THC. Since Δ9-THC has "no" binding potential for estrogen receptor α (ERα) which can be activated by estrogen (E2), the question of how Δ9-THC exerts its inhibitory effect on ERα is not resolved. We have recently reported that ERβ, a second type of ER, is involved in the Δ9-THC abrogation of E2/ERα-mediated transcriptional activity. Here we discuss the possible mechanism(s) of the Δ9-THC-mediated disruption of E2/ERα signaling by presenting our recent findings as well. © 2014 The Pharmaceutical Society of Japan. Source

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