Hiroshima, Japan

Hiroshima Institute of Technology is a private university in Saeki, Hiroshima, Japan. It was established by Tsuru Gakuen in 1961 as a two-year college, and became a four-year university in 1963, taking its present name. The university has faculties of engineering, applied information science, and environmental studies. Each has multiple departments.Alumni of Hiroshima Institute of Technology include comedian Yohichi Shimada, Robotics Pioneer Yokomichi Nobukatsu, architect Tōru Murakami, and software entrepreneur Toru Takasuka. Wikipedia.

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Hinamoto T.,Hiroshima Institute of Technology | Doi A.,Hiroshima Institute of Technology | Lu W.-S.,University of Victoria
IEEE Transactions on Signal Processing | Year: 2013

Joint optimization of high-order error feedback and state-space realization for minimizing roundoff noise at filter output subject to l2-scaling constraints is investigated for one- and two-dimensional state-space digital filters. Linear algebraic techniques that convert the problems at hand into an unconstrained optimization problem are explored, and an efficient quasi-Newton algorithm is then applied to solve the unconstrained optimization problem iteratively. In this connection, closed-form formulas are derived for fast and accurate gradient evaluation. Finally, case studies are presented to demonstrate that the high-order error feedback does offer much improved performance and that the proposed joint optimization is superior relative to a sequentially optimized system where the state-space coordinate transformation and high-order error feedback matrices are optimized separately. © 1991-2012 IEEE.

Ochi K.,Hiroshima Institute of Technology | Okamoto S.,Japan National Food Research Institute
Chemistry and Biology | Year: 2012

Activation/exploitation of biosynthetic pathways for useful metabolites is a major current interest. The metabolism remodeling approach developed by Craney and colleagues in this issue of (Chemistry & Biology), in which small molecule probes alter the secondary metabolites produced by streptomycetes, could lead to discovery of a multitude of novel antibiotics and other drugs. © 2012 Elsevier Ltd.

Inaoka T.,Japan National Food Research Institute | Ochi K.,Hiroshima Institute of Technology
Journal of Bacteriology | Year: 2012

The rare earth element scandium has weak antibacterial potency. We identified a mutation responsible for a scandium-resistant phenotype in Bacillus subtilis. This mutation was found within the uppS gene, which encodes undecaprenyl pyrophosphate synthase, and designated uppS86 (for the Thr-to-Ile amino acid substitution at residue 86 of undecaprenyl pyrophosphate synthase). The uppS86 mutation also gave rise to increased resistance to bacitracin, which prevents cell wall synthesis by inhibiting the dephosphorylation of undecaprenyl pyrophosphate, in addition to enhanced amylase production. Conversely, overexpression of the wild-type uppS gene resulted in increased susceptibilities to both scandium and bacitracin. Moreover, the mutant lacking undecaprenyl pyrophosphate phosphatase (BcrC) showed increased susceptibility to all rare earth elements tested. These results suggest that the accumulation of undecaprenyl pyrophosphate renders cells more susceptible to rare earth elements. The availability of undecaprenyl pyrophosphate may be an important determinant for susceptibility to rare earth elements, such as scandium. © 2012, American Society for Microbiology.

Ochi K.,Hiroshima Institute of Technology | Hosaka T.,Shinshu University
Applied Microbiology and Biotechnology | Year: 2013

Genome sequencing of Streptomyces, myxobacteria, and fungi showed that although each strain contains genes that encode the enzymes to synthesize a plethora of potential secondary metabolites, only a fraction are expressed during fermentation. Interest has therefore grown in the activation of these cryptic pathways. We review current progress on this topic, describing concepts for activating silent genes, utilization of "natural" mutant-type RNA polymerases and rare earth elements, and the applicability of ribosome engineering to myxobacteria and fungi, the microbial groups known as excellent searching sources, as well as actinomycetes, for secondary metabolites. © 2012 The Author(s).

Tanaka K.,Hiroshima Institute of Technology
Natural Hazards and Earth System Science | Year: 2010

A meteotsunami hit southwest Kyushu on 25 February 2009, with an estimated maximum amplitude of 290 cm, which was higher than that recorded for the 1979 Nagasaki event. This study investigated mesoscale meteorological systems over the East China Sea during the time leading up to the February 2009 event using a Weather Research and Forecast model. The disturbance in the sea-level pressure originated from a gravity wave over southeastern China. The sea-level pressure disturbance observed and modelled over the East China Sea had its source over the southeastern China mountains and was then propagated by a jet stream toward western Japan with the help of both wave-duct and wave-CISK (conditional instability of the second kind) mechanisms. Two synoptic systems supported the momentum convergence and the formation of band-shaped unstable layers in the mid-troposphere. The high-latitude trough extended from eastern Siberia and there was subtropical high pressure over the western Pacific Ocean. The phase speed of the atmospheric wave was as high as 25-30 ms-1, corresponding to the phase speed of long ocean waves on the East China Sea. Improvements in determining the amplitude and timing of the disturbance remain for future work. © 2010 Author(s).

Ebara R.,Hiroshima Institute of Technology
Procedia Engineering | Year: 2010

Corrosion fatigue crack initiation behavior of various kinds of stainless steels is reviewed mainly on the basis of the author's experimental results. The role of corrosion pit in the corrosion fatigue crack initiation process of martensitic, ferritic, austenitic, duplex and precipitation-hardening stainless steels is briefly summarized. The recent investigation of an electrochemical noise measurement method is demonstrated for 12%Cr martensitic stainless steel and 2.5%Mo containing high strength austenitic stainless steels. Finally a couple of future problems to be solved in corrosion fatigue crack initiation are touched on briefly. © 2010 Published by Elsevier Ltd.

Hirose H.,Hiroshima Institute of Technology
Proceedings - 2016 5th IIAI International Congress on Advanced Applied Informatics, IIAI-AAI 2016 | Year: 2016

Item response theory (IRT) provides more accurate and fairer evaluations of individual abilities than classical test theory does, and thus the IRT has gradually been recognized as one of the proper evaluation methodologies in many testing fields. Teaching using textbooks works in university education as well as self-studying using online learning systems. However, they have not been connected each other. Thus, to utilize both beneficial sides of textbooks and the internet system, we propose a new learning style using textbooks and online testing for exercises using the adaptive online IRT testing systems, called Ai Arutte. In this paper, we introduce a new use of the adaptive online IRT testing system to assist self-learning in studying undergraduate subject, Linear Algebra, and we show its learning analytics. The combination of a mathematical textbook and the adaptive online IRT system works well. Ai Arutte case shows that students feel this kind of self-studying is fun and interesting. © 2016 IEEE.

Ochi K.,Hiroshima Institute of Technology | Tanaka Y.,Hiroshima Institute of Technology | Tojo S.,Hiroshima Institute of Technology
Journal of Industrial Microbiology and Biotechnology | Year: 2014

Since bacteria were found to contain genes encoding enzymes that synthesize a plethora of potential secondary metabolites, interest has grown in the activation of these cryptic pathways. Homologous and heterologous expression of these cryptic secondary metabolite-biosynthetic genes, often "silent" under ordinary laboratory fermentation conditions, may lead to the discovery of novel secondary metabolites. We review current progress on this topic, describing concepts for activating silent genes. We especially focus on genetic manipulation of transcription and translation, as well as the utilization of rare earth elements as a novel method to activate the silent genes. The possible roles of silent genes in bacterial physiology are also discussed. © 2013 Society for Industrial Microbiology and Biotechnology.

Ebara R.,Hiroshima Institute of Technology
International Journal of Fatigue | Year: 2010

In this paper, fatigue crack initiation and propagation behavior of forging die steels are reviewed mainly on the basis of the author's experimental results. First of all, low cycle fatigue strength, fatigue crack propagation behavior and thermal fatigue properties of the representative hot forging die steel SKD62 are summarized with respect to testing temperature, steel hardness, stress concentration factor of the specimen and surface treatments effect. Then, the emphasis is focused upon the recently obtained experimental results on low cycle, high cycle and giga cycle fatigue behavior of cold forging die steels. Fatigue crack initiation and propagation behavior of cold forging die steels is discussed with respect to steel hardness, surface roughness and stress concentration factor of specimen. Characteristics of fatigue fracture surface morphology is summarized and related to fatigue crack initiation and propagation mechanism of hot and cold forging die steels. Finally, recommended studies on fatigue of forging die steels are touched on briefly. © 2009 Elsevier Ltd. All rights reserved.

Takao S.,Hiroshima Institute of Technology
Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases | Year: 2011

Luminex xTAG respiratory viral panel FAST (RVP FAST) assay detects 17 human respiratory virus strains per measurement. Studying RVP FAST efficacy in detecting respiratory viruses in 67 aspirate samples from the nasal cavities of children with acute respiratory infection, we compared RVP FAST results to those of conventional nucleic acid amplification tests (NAT), e.g., real-time PCR, targeting 8 strains. RVP FAST assay detected 13 strains (98 isolates) in 59 of 67 samples. Of these, 8--influenza virus (Inf.V)-AH1, Inf. V-AH3, novel Inf.V-AH1, and Inf.V-B, and adenovirus, RS virus, metapneumovirus, and bocavirus--were compared to NAT results. RVP FAST showed higher sensitivity (83.3-100%) and specificity (98.2-100%) than NAT. RVP FAST also detected coronavirus (CoV) 229E, OC43, NL63, and HKU1 from 10 virus strain samples and enterovirus and/or rhinovirus from 35. RVP FAST assay thus comprehensively detects clinically important viruses in a single measurement, making RVP FAST assay useful in detecting causative respiratory tract viruses.

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