Hiroshima-shi, Japan
Hiroshima-shi, Japan

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Nakamura Y.,Hiroshima University | Hirokawa Y.,Hiroshima Heiwa Clinic | Kitamura S.,Hiroshima Heiwa Clinic | Yamasaki W.,Hiroshima City Hospital | And 6 more authors.
Japanese Journal of Radiology | Year: 2013

Purpose: The purpose of this study was to investigate the effect of lapatinib treatment on hepatic parenchymal enhancement on Gd-EOB-MRI scans in rat. Materials and methods: Institutional animal review board approval was received prior to the commencement of all studies. Five rats received a single oral dose of 100 mg/kg/day lapatinib for 7 consecutive days. The controls (n = 5) were given 0.5 % (w/v) aqueous hydroxypropyl methyl cellulose containing 0.1 % (v/v) Tween 80 for 7 days. After the acquisition of gadoxetate disodium-enhanced MR images using 0.025 mmol gadolinium/kg, their livers were subjected to pathologic study to determine the expression level of organic anion-transporting polypeptide 1 (oatp1) and multi-drug resistance-associated protein 2 (mrp2). Results: Relative enhancement of the liver was similar in both groups. At the hepatobiliary phase, which in rats occurs 3 min after the injection of Gd-EOB, it was 0.90 ± 0.06 in lapatinib-treated rats and 0.84 ± 0.08 in the controls (p = 0.30). There was also no difference in the expression level of oatp1 and mrp2. Conclusion: In rats, the administration of lapatinib for 7 days had no effect on hepatic parenchymal enhancement on Gd-EOB-MRI scans. © 2013 Japan Radiological Society.


Tamura T.,Health Management and Promotion Center | Tamura T.,Hiroshima International University | Usui S.,Hiroshima International University | Murakami S.,Hiroshima Asa City Hospital | And 5 more authors.
Magnetic Resonance in Medicine | Year: 2012

Previous studies have reported that the signal attenuation of diffusion weighted magnetic resonance imaging for tumor tissues displays a non-monoexponential biexponential decay, and the apparent diffusion coefficients (ADCs) can be divided into a fast and slow diffusion component by using a simple biexponential decay model. The purpose of this study is to examine the non-monoexponential character of the diffusion weighted magnetic resonance imaging signal attenuations of breast cancers, estimate the fast and slow diffusion components, and compare them with the extra- and intracellular component information obtained from the pathological specimens. Twenty-two subjects having breast cancers underwent diffusion weighted magnetic resonance imaging using six b-values up to 3500 s/mm2 and the signal attenuations were analyzed using the biexponential function. The derived slow component fraction correlated with the cellular fraction and the ADCs converged to 0.2-0.3 × 10-3 mm2/s for the higher cellular fractions. The ADCs of the fast component ranged from 1.3 to 3.9 × 10 -3 mm2/s and showed no correlation with the extracellular components. This result suggests that the main reason for the decreasing ADC of a breast tumor is the decreasing fraction of the fast component and the increasing fraction of the slow component having a low ADC rather than the decreasing ADC of the fast component by the restricted water diffusion in the reduced extracellular spaces. Copyright © 2011 Wiley Periodicals, Inc.


Tamura T.,Health Management and Promotion Center | Murakami S.,Hiroshima Asa City Hospital | Naito K.,Health Management and Promotion Center | Yamada T.,Health Management and Promotion Center | And 2 more authors.
Cancer Imaging | Year: 2014

Background: Previous studies have reported that the signal attenuation of diffusion-weighted magnetic resonance imaging (DWI) for normal breast tissue and tumor were well fitted by a monoexponential and a biexponential function, respectively. The aim of this study was to investigate the optimal b-value to detect breast tumors from DWI signal attenuations. Methods: Sixty-four subjects with breast cancer underwent DWI using six b-values up to 3500 s/mm2. The signal attenuations of normal breast and tumor were fitted by mono- and biexponential functions, respectively. The maximum contrast b-values were estimated and compared in terms of frequency. Results: In almost all cases, the contrast increased with a b-value from 0 to approximately 1500 s/mm2. For b > 1500 s/mm2, the contrast decreased. The highest contrast b-value in the range of 0 to 2500 s/mm2 most frequently was b = 1500 and the next most frequent was 1400 s/mm2. Comparing sensitivity and specificity between b = 700 and b = 1400 s/mm2, b =1400 s/mm2 was slightly superior. Conclusion: Based on these results, DWI with a b-value of approximately 1400-1500 s/mm2 is recommended for optimizing breast tumor detectability. © 2014 Tamura et al.; licensee BioMed Central Ltd.


Nakayama N.,Hiroshima Asa City Hospital | Nagata S.,Hiroshima Asa City Hospital | Kaneko M.,Hiroshima Asa City Hospital | Shigita K.,Hiroshima Asa City Hospital | And 7 more authors.
Gastroenterological Endoscopy | Year: 2010

An 82-year-old male suffered from long term watery diarrhea after taking lansoprazole. At first, there were no finding on colonoscopic examination, but one year later, colonoscopic findings showed a mucosal appearance with redness, and in the year after that, granulation and edema, at the proximal colon with indistinct vascular transparency. A colonic mucosal biopsy showed prominent subepithelial collagen band thickening, and so this case was diagnosed as collagenous colitis. The patient got relief from his diarrhea after only one week after changing lansoprazole to omeprazole. Colonoscopic and pathological findings were also improved after four months.

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