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Karras S.,Unit of Reproductive Endocrinology | Anagnostis P.,Hippokration Hospital of Thessaloniki | Noussios G.,Aristotle University of Thessaloniki | Pontikides N.,Agios Pavlos General Hospital
BMJ Case Reports | Year: 2013

Ectopic thyroid tissue comprises a rare clinical entity which can clinically manifest with the whole spectrum of thyroid disorders, including thyroid malignancy. Thyroid carcinoma arising in ectopic thyroid tissue is extremely rare, with only a few cases described in the literature so far. We present a very unusual case of a primary papillary thyroid carcinoma arising in a left lateral branchial cyst, describing our diagnostic and therapeutic approach for this uncommon clinical entity. This is the first case where recombinant thyrotropin was used along with radioiodine treatment in primary ectopic thyroid cancer. Copyright 2013 BMJ Publishing Group. All rights reserved.

Noussios G.,Aristotle University of Thessaloniki | Anagnostis P.,Hippokration Hospital of Thessaloniki | Goulis D.G.,Aristotle University of Thessaloniki | Lappas D.,National and Kapodistrian University of Athens | Natsis K.,Aristotle University of Thessaloniki
European Journal of Endocrinology | Year: 2011

Ectopic thyroid tissue is a rare entity resulting from developmental defects at early stages of thyroid gland embryogenesis, during its passage from the floor of the primitive foregut to its final pre-tracheal position. It is frequently found around the course of the thyroglossal duct or laterally in the neck, as well as in distant places such as the mediastinum and the subdiaphragmatic organs. Although most cases are asymptomatic, symptoms related to tumor size and its relationship with surrounding tissues may also appear. Any disease affecting the thyroid gland may also involve the ectopic thyroid, including malignancy. The clinician must distinguish between ectopic thyroid and metastatic deposits emerging from an orthotopic gland, as well as other benign or malignant masses. Thyroid scintigraphy plays the most important role in diagnosing ectopy, but ultrasonography contributes as well. In cases of symptomatic disease, surgery is the treatment of choice, followed by radioiodine ablation and levothyroxine suppression therapy in more refractory cases. This review provides current understanding about the wide clinical spectrum of this rare condition, also referring to optimal diagnostic approach, differential diagnosis, and management strategies. © 2011 European Society of Endocrinology.

Stavrakaki S.,Aristotle University of Thessaloniki | Alexiadou A.,University of Stuttgart | Kambanaros M.,University of Cyprus | Bostantjopoulou S.,Aristotle University of Thessaloniki | Katsarou Z.,Hippokration Hospital of Thessaloniki
Aphasiology | Year: 2011

Background: Recent studies revealed that aphasic speakers have difficulties with the production of the intransitive (unaccusative) variant of verbs entering transitivity alternations. A key point of the current interpretations of these difficulties concerns the movement operations taking place at surface syntax, namely, the A-movement operation (Bastiaanse & van Zonneveld, 2005; Bastiaanse, 2008; Thompson, 2003). Aim: The present study revisits the issue of processing verbs with alternating transitivity in non-fluent aphasia in Greek, a language with rich morphology and relatively free word order, which lacks A-movement. In addition, in Greek, unaccusative verbs appear with different voice morphology: One class of intransitive variants of alternating verbs bears active morphology, another one non-active morphology and a third one can surface with both. The presence of non-active voice has been argued to correspond to the presence of a voice projection in syntax of these variants, while the variants that bear active morphology are not associated with a voice projection at the level of syntax. This study investigates the ability of non-fluent aphasic speakers to produce and comprehend verbs entering transitivity alterations and explores the role of active vs. non-active morphology and word order in the performance of aphasic speakers. Methods & Procedures: We tested five non-fluent patients and fifteen control participants. We used two tasks supported by pictures: an elicited production task and a comprehension task. The experimental material consisted of fifteen transitive and fifteen unaccusative verbs (marked for active, and/or non-active voice morphology) in sentence contexts. Outcomes & Results: The results indicated that (i) the aphasic speakers performed better on the production and comprehension of transitives than of unaccusatives, (ii) they showed significantly lower performance on the comprehension of unaccusatives with active morphology than on unaccusatives with non-active morphology, and finally (iii) they produced transitive (S)VO structures instead of the unaccusative ones. Conclusion: We suggest, in agreement with other researchers (for example, Schwartz, Linebarger, Saffran, & Pate, 1987) that aphasic individuals overuse a mapping strategy that associates the theta roles of agent and theme with syntactic subject and object respectively, as they produce transitive (S)VO structures, to a large extent, instead of unaccusatives. In addition, as they had difficulties with unaccusative verbs marked for active voice, we suggest that they could not successfully interpret unaccusative verbs with active voice morphology as non-agentive structures. © 2011 Psychology Press.

Lappas D.,National and Kapodistrian University of Athens | Noussios G.,Aristotle University of Thessaloniki | Anagnostis P.,Hippokration Hospital of Thessaloniki | Adamidou F.,Hippokration Hospital of Thessaloniki | And 2 more authors.
Anatomical Science International | Year: 2012

Surgical management of parathyroid gland disease may sometimes be difficult, due mainly to the surgeon's failure to successfully detect parathyroids in unusual locations. The records of 942 cadavers (574 men and 368 women) who underwent autopsy in the Department of Forensic Medicine in Athens during the period 1988-2009 were reviewed. In total, 3,796 parathyroid glands were resected and histologically verified. Parathyroid glands varied in number. In 47 cases (5 %), one supernumerary (fifth) parathyroid was found, while in 19 cases (2 %) three parathyroid glands found. Superior glands were larger than inferior ones. However, there was no significant difference between the genders with respect to gland size. In 324 (8.5 %) out of 3,796, the glands were detected in an ectopic location: 7 (0.2 %) in the thyroid parenchyma, 79 (2 %) in different sites in the neck and 238 (6.3 %) in the mediastinum, 152 (4.1 %) of which were found in the upper and 86 (2.2 %) in the lower mediastinum. Significant anatomical variations of normal parathyroid glands may exist regarding number and location-knowledge that is essential for their successful identification and surgical management. © 2012 Japanese Association of Anatomists.

Kozeis N.,Hippokration Hospital of Thessaloniki | Trachana M.,Rheumatology Referral Center | Tyradellis S.,Hippokration Hospital of Thessaloniki
Cornea | Year: 2011

Purpose: To present a rare ocular manifestation of reactive arthritis (Reiter syndrome) in a child. Methods: A 10-year-old girl who was admitted to our hospital with low-grade fever, arthritis, and aching left eye with blurred vision was diagnosed with Reiter reactive arthritis. At the time of admittance, the ophthalmologic examination revealed keratitis; this mildly affected the vision. Results: Keratitis resolved under treatment with topical steroids and antibiotic drops after 1 month, without scarring. Although 75% of the patients with reactive arthritis present ophthalmic manifestations, keratitis is a very rare finding in reactive arthritis and even rarer in children. Conclusions: It should be kept in mind that keratitis could be an ocular manifestation of reactive arthritis in young patients. Copyright © 2011 by Lippincott Williams & Wilkins.

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