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Pfaffenhofen an der Roth, Germany

Koletzko B.,Ludwig Maximilians University of Munich | Agostoni C.,University of Milan | Bergmann R.,Charite - Medical University of Berlin | Ritzenthaler K.,HiPP GmbH and Co. Vertrieb KG | Shamir R.,Tel Aviv University
Acta Paediatrica, International Journal of Paediatrics | Year: 2011

The biology of human milk and lactation helps understand the physiology of breastfed infants. The compositional and biological effects of human milk lipids have received considerable interest regarding their modulating effects on growth, metabolism and functions of the cardiovascular, immune and nervous system. Conclusion: This paper describes key aspects of a scientific workshop focused on current knowledge, unresolved questions and future research needs in the area of human milk lipids and their physiological effects in infants. © 2011 The Author(s)/Acta Pædiatrica © 2011 Foundation Acta Pædiatrica. Source


Soto A.,Complutense University of Madrid | Martin V.,Probisearch | Jimenez E.,HiPP GmbH and Co. Vertrieb KG | Mader I.,HiPP GmbH and Co. Vertrieb KG | And 2 more authors.
Journal of Pediatric Gastroenterology and Nutrition | Year: 2014

Objective: The objective of this work was to study the lactobacilli and bifidobacteria population in human milk of healthy women, and to investigate the influence that several factors (including antibioteraphy during pregnancy and lactation, country and date of birth, delivery mode, or infant age) may exert on such population. Methods: A total of 160 women living in Germany or Austria provided the breast milk samples. Initially, 66 samples were randomly selected and cultured on MRS-Cys agar plates. Then, the presence of DNA from the genera Lactobacillus and Bifidobacterium, and from most of the Lactobacillus and Bifidobacterium species that were isolated, was assessed by qualitative polymerase chain reaction (PCR) using genus- and speciesspecific primers. Results: Lactobacilli and bifidobacteria could be isolated from the milk of 27 (40.91%) and 7 (10.61%), respectively, of the 66 cultured samples. On the contrary, Lactobacillus and Bifidobacterium sequences were detected by PCR in 108 (67.50%) and 41 (25.62%), respectively, of the 160 samples analyzed. The Lactobacillus speciesmost frequently isolated and detectedwas L salivarius (35.00%), followed by L fermentum (25.00%) and L gasseri (21.88%), whereas B breve (13.75%) was the bifidobacterial species most commonly recovered and whose DNA was most regularly found. The number of lactobacilli- or bifidobacteria-positive samples was significantly lower in women who had received antibiotherapy during pregnancy or lactation. Conclusions: Our results suggest that either the presence of lactobacilli and/ or bifidobacteria or their DNA may constitute good markers of a healthy human milk microbiota that has not been altered by the use of antibiotics. Copyright © 2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Source


Gil-Campos M.,Hospital Universitario Reina Sofia | Lopez M.A.,Hospital Universitario Virgen Of Las Nieves | Rodriguez-Benitez M.V.,Hospital Universitario Reina Sofia | Romero J.,Hospital Universitario Virgen Of Las Nieves | And 14 more authors.
Pharmacological Research | Year: 2012

The objective of the study was to evaluate the safety and tolerance of an infant formula supplemented with Lactobacillus fermentum CECT5716, a probiotic strain isolated from breast milk, in infants of 1-6 months of age. A randomized double blinded controlled study including healthy infants was conducted. One month aged infants received a prebiotic infant formula supplemented with L. fermentum (experimental group) or the same formula without the probiotic strain (control group) for 5 months. The primary outcome of the study was average daily weight gain between baseline and 4 months of age. Secondary outcomes were other anthropometric data (length and head circumference), formula consumption, and tolerance. Incidence of infections was also recorded by pediatricians. No significant differences in weight gain were observed between both groups, neither at 4 months of age (29.0 ± 7.8 vs 28.9 ± 5.7 g/day) nor at 6 months (25.1 ± 6.1 vs 24.7 ± 5.2 g/day). There were no statistically significant differences in the consumption of the formulae or symptoms related to the tolerance of the formula. The incidence rate of gastrointestinal infections in infants of the control group was 3 times higher than in the probiotic group (p = 0.018). Therefore, consumption of a prebiotic infant formula enriched with the human milk probiotic strain L. fermentum CECT5716 from 1 to 6 months of life is well tolerated and safe. Furthermore, the consumption of this formula may improve the health of the infants by reducing the incidence of gastrointestinal infections. © 2011 Elsevier Ltd. All rights reserved. Source


Hower J.,Uberortliche Gemeinschaftspraxis fur Kinder und Jugendmedizin Standort Dumpten | Knoll A.,Freelance Statistician | Ritzenthaler K.L.,HiPP GmbH and Co. Vertrieb KG | Steiner C.,HiPP GmbH and Co. Vertrieb KG | Berwind R.,HiPP GmbH and Co. Vertrieb KG
European Journal of Pediatrics | Year: 2013

Vitamin D plays an important role in human health. Current recommendations for vitamin D intake and endogenous supply through sun exposure are not met in German pre-school children, and suboptimal serum 25-hydroxyvitamin D concentrations, especially during the winter months, are common. Consequently, vitamin D supplementation or fortification have gained increased acceptance. The KiMi trial (Kindermilch = growing up milk) was a prospective, randomized, and double-blind study in which young children (2-6 years of age, n = 92) were assigned to receive either vitamin D-fortified growing up milk (2.85 μg/100 ml) or semi skimmed cow's milk without added vitamin D. Daily consumption of fortified growing up milk contributed to the prevention of an otherwise frequently observed decrease in serum 25-hydroxyvitamin D concentration during winter (before winter: median 21.5 ng/mL (10.1-43.0 ng/mL) intervention vs. median 18.4 ng/mL (11.0-44.9 ng/mL) control; after winter: median 24.8 ng/mL (7.0-48.2 ng/mL) intervention vs. median 13.6 ng/mL (7.0-36.8 ng/mL) control) and proved to be safe during summer (median 27.6 ng/mL (18.8-40.5 ng/mL) intervention vs. median 27.4 ng/mL (17.8-38.7 ng/mL) control). Due to the high prevalence of vitamin D deficiency, fortification of growing up milk with vitamin D at a level used in this study could be an effective measure to improve vitamin D status. © 2013 Springer-Verlag Berlin Heidelberg. Source

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