Hindustan Gum and Chemicals Ltd

Bhiwāni, India

Hindustan Gum and Chemicals Ltd

Bhiwāni, India
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Ghosh S.,Hindustan Gum and Chemicals Ltd. | Pal S.,Indian School of Mines
International Journal of Biological Macromolecules | Year: 2013

pH dependent hydrogels of modified tamarind kernel polysaccharide (TKP) were synthesized by grafting with polyacrylamide chains on TKP backbone in presence of microwave irradiation and initiator. The present study is carried out to design oral controlled drug delivery systems for aspirin using synthesized hydrogels as carrier in form of tablets. TKP-g-PAM based hydrogels show significant enhancement for control release of aspirin. Release behavior of aspirin has been evaluated using USP type I apparatus in 900mL of buffer solutions (pH 1.2, 6.8, 7.4), maintained at 37°C at 100rpm. It is observed that with increase in percentage of grafting (% G), swelling of matrices increases whereas erosion and rate of drug release decrease. The effect of % G onto t50 value (time taken for release of 50% drug) has also been discussed. The release characteristics from the matrices under study show non-Fickian diffusion mechanism, suggesting the controlled release of aspirin. © 2013 Elsevier B.V.


Ali Sk.A.,Hindustan Gum and Chemicals Ltd | Pal S.,Indian School of Mines | Singh R.P.,Indian Institute of Science
Journal of Applied Polymer Science | Year: 2010

A cationic moiety, N-(3-chloro-2-hydroxypropyl) trimethyl ammonium chloride (CHPTAC), was incorporated onto chitosan in an aqueous alkaline solution. Thus, modified chitosan was prepared. A series of modified chitosans with different molecular weights and charge densities were synthesized through the alteration of the molar ratio of CHPTAC to chitosan in the reaction mixture. The synthesized modified chitosans were thereafter characterized by a variety of physicochemical characterization techniques to confirm that modification did take place. Furthermore, the feasibility of applying modified chitosans as flocculants was assessed, and they were compared with the native chitosan in model colloidal suspensions of kaolin and iron-ore powder. The results indicated that the unmodified chitosan itself was a good flocculating agent. The flocculation performance of the chitosan could be altered by the incorporation of the CHPTAC moiety. Studies showed that not all the modified chitosans had superior flocculation performance versus the native chitosan. Among the different grades, the modified chitosan with a moderate molecular weight and a moderate charge density showed the best flocculation performance in both model suspensions. © 2010 Wiley Periodicals.


Banerjee C.,Birla Institute of Technology | Ghosh S.,Birla Institute of Technology | Ghosh S.,Hindustan Gum and Chemicals Ltd | Sen G.,Birla Institute of Technology | And 4 more authors.
Bioresource Technology | Year: 2014

Green unicellular microalgae have a capacity to entrap CO2 to increase their biomass through photosynthesis and are important for the value added product. The presence of COOH and NH2 groups are responsible for imparting negative zeta value. The present work emphasizes on the synthesis of cationic cassia (CCAS) by the insertion of quaternary amine groups onto the backbone of cassia (CAS) from N-3-Chloro-2-hydroxypropyl trimethyl ammonium chloride (CHPTAC) which was further characterized via FTIR, SEM, elemental analysis and intrinsic viscosity. The optimal dosage of the synthesized cationic cassia is used to flocculate two different green fresh water algae viz. Chlamydomonas sp. CRP7 and Chlorella sp. CB4 were evaluated. 80 and 35mgL-1 was optimized dose for dewatering of above algae, respectively. © 2013 Elsevier Ltd.


Banerjee C.,Birla Institute of Technology | Ghosh S.,Birla Institute of Technology | Ghosh S.,Hindustan Gum and Chemicals Ltd | Sen G.,Birla Institute of Technology | And 4 more authors.
Carbohydrate Polymers | Year: 2013

Microalgae are small in size with negatively charged surface. They are usually stable in suspension culture and hard to flocculate. The present work emphasizes on the synthesis of cationic guar gum (CGG) by the introduction of quaternary amine groups onto the backbone of guar gum (GG) from N-(3-chloro-2-hydroxypropyl) trimethyl ammonium chloride (CHPTAC). The optimal dosage of the synthesized cationic guar gum is used to flocculate two different green algae viz. Chlorella sp. CB4 and Chlamydomonas sp. CRP7. © 2012 Elsevier Ltd. All rights reserved.

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