Dwārka, India
Dwārka, India

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Dixit M.B.,Hindurao Hospital | Banavaliker J.N.,RBIPMT
Journal of Anaesthesiology Clinical Pharmacology | Year: 2013

Pyrethroid insecticides are very widely used in agriculture and household due to their high effectiveness and low toxicity in humans. Despite their extensive worldwide use, there are a few reports of human pyrethroid poisoning. The poisoning has a varied presentation and its symptoms overlap with those of other compounds, which can lead to misdiagnosis. We present a case of poisoning with prallethrin, a pyrethroid compound, commonly available as All-Out.


Banavaliker J.N.,RBIPMT | Dixit R.M.,Hindurao Hospital
Anaesthesia, Pain and Intensive Care | Year: 2012

Gilbert's syndrome is a form of hereditary non-hemolytic jaundice transmitted by autosomal dominant pattern. Since there is low glucuronyl transferase activity in the liver there is a risk for anesthetic toxicity with a possibility of a catastrophic outcome. It is important for the anesthesiologists to understand the the pathophysiology of the disease and the conditions leading to decreased glucuronyl transferase activity. We report a case of Gilbert's syndrome with hypertension, operated for cholelithiasis under thoracic epidural analgesia supplemented with transcutaneous electrical nerve stimulation in the postoperative period. Minimal administration of intravenous drugs, maintaining the organ perfusion and postoperative pain relief using epidural anesthesia offers a safe conduct of anesthesia which can be considered as an alternative to general anesthesia.


Chandra A.,Hindurao Hospital | Thakur V.,Hindurao Hospital | Bhasin N.,Hindurao Hospital | Gupta D.,Hindurao Hospital
Anaesthesia, Pain and Intensive Care | Year: 2014

Background: Pre-operative testing has been criticized as having little impact on peri-operative outcomes. The aim of this study was to establish the number of unnecessary pre-operative investigations undertaken in American Society of Anesthesiologists (ASA) Grade I patients undergoing general surgery. Methodology: The clinical record of 1200 patients, who underwent surgery in a period of 6 months from June 2012 to December 2012, were screened, out of which record of 500 ASA-I patients, aged 15-50 years, undergoing cholecystectomy and hernia repair were reviewed. Pre-operative investigations were assessed in terms of frequency of use and abnormalities detected. It was also checked whether the abnormal results altered the patient's management. The peri-operative complications if any were noted and their co-relation to the investigations was established. The total cost of investigations was calculated. Result: All 100% of the patients had had preoperative tests for hemoglobin, total leucocyte count, differential leucocyte count, urine routine examination, random blood sugar and blood urea levels. Platelet count was done in 90%, serum creatinine in 50%, liver function tests in 55%, x-ray chest in 94% and electrocardiogram in 84% of the patients. No change in the plan of anesthesia was made in any of these cases. 7.5% of the patients required some intra-operative or post-operative intervention. The total cost of processing the requested investigations as per the list provided by the Central Government Health Services (CGHS) was Rs 3,62,125 or IRs. 724.25 per patient. Conclusion: We conclude that routine pre-operative investigations are unnecessary in ASA Grade-I patients undergoing low to moderate risk general surgery. There is a need to have guidelines for indicated tests in different groups of diseases and procedures, to be ordered by the anesthesiologists to prevent unnecessary wastage of time, money, and resources and to avoid overburdening laboratory staff.


Chandra A.,Hindurao Hospital | Ranjan R.,Hindurao Hospital | Kumar J.,Hindurao Hospital | Vohra A.,Hindurao Hospital | Thakur V.K.,Hindurao Hospital
Journal of Anaesthesiology Clinical Pharmacology | Year: 2016

Background and Aims: Penetrating eye injuries are a challenge for the anesthesiologists in emergency due to increase in intraocular pressure (IOP). The aim of this study was to evaluate the effects of intravenous dexmedetomidine premedication on changes in IOP and hemodynamic response following laryngoscopy and tracheal intubation. Material and Methods: Hundred patients aged 18-60 years undergoing elective nonophthalmic surgery were divided into two groups of 50 each. Group D received a bolus dose of dexmedetomidine (0.4 μg/kg) diluted to 20 ml normal saline and Group C received normal saline (0.4 ml/kg) over 10 min as premedication. Heart rate (HR), systolic blood pressure (SBP) and IOP were measured and recorded before premedication (T1), 5 and 10 m after premedication (T2, T3), immediately after induction, intubation and then 1, 3, 5 min after intubation (T4, 5, 6, 7, 8). Results: HR was comparable in both groups at preoperative level, but it was significantly low in the drug group when compared with the control group at T4-T8 (P = 0.034, P < 0.001, 0.001, 0.036 and 0.001, respectively). The SBP was comparable in both the groups at baseline and till before induction. At T4-T8 there was a fall in SBP in Group D compared to the Group C (P = 0.045, P = 0.007, 0.001, 0.001 and 0.001, respectively). The baseline IOP was comparable in both the groups (P = NS). There was a significant fall in the IOP in Group D, 5 min after the drug infusion compared to Group C, which was sustained till 5 min after intubation (T8) (P < 0.001 at all intervals). Conclusion: Dexmedetomidine premedication in the dose of 0.4 μg/kg lowers the IOP and attenuates the pressor response to laryngoscopy and intubation. © 2016 Journal of Anaesthesiology Clinical Pharmacology | Published by Wolters Kluwer - Medknow.


Jain A.,Hindurao Hospital | Dixit S.,Hindurao Hospital | Datar S.,Hindurao Hospital | Jain P.K.,Hindurao Hospital
Indian Journal of Pediatrics | Year: 2010

Teratomas form the most common type of congenital brain tumors, frequently presenting as stillbirth. The largest neonatal series of intracranial teratomas reported a 12% survival rate. Although the first teratoma of the lateral ventricle was reported in 1961 by Maier, neonatal intracranial teratoma of the lateral ventricle is an extremely rare entity. We report here a large intracranial poorly differentiated teratoma arising from choroid plexus of lateral ventricle. This typically presented at birth with a large congenital hydrocephalus.


Kalita D.,HinduRao Hospital | Pant L.,HinduRao Hospital | Singh S.,HinduRao Hospital | Jain G.,HinduRao Hospital | And 3 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013

Gall bladder carcinoma is the most common cancer of biliary tree, characterized by rapid progression and a very high mortality rate. Detection at an early stage, however, is indicative of a very good prognosis and prolonged survival. The practice of histopathological examination of gall bladder specimens removed for clinically benign conditions and its usefulness has been a subject of controversy. The present prospective study was carried out over a period of four years in order to find out the incidence of unsuspected gallbladder carcinoma in cholecystectomy specimens received in our histopathology laboratory and to analyze their clinico-pathological features. A total of 4,115 cases were examined. Incidentally detected cases comprised 0.44%, which accounted for 72% of all gall bladder carcinomas detected. The majority were in an early, surgically resectable stage. From the results of this study we recommend that in India and other countries with relatively high incidences of gall bladder carcinoma, all cholecystectomy specimens should be submitted to histopathology laboratory, as this is the only means by which malignancies can be detected at an early, potentially curable stage.


Chandra A.,Hindurao Hospital | Pathak A.,Hindurao Hospital | Kapur A.,Hindurao Hospital | Russia N.,Hindurao Hospital | Bhasin N.,Hindurao Hospital
Indian Journal of Critical Care Medicine | Year: 2014

A case of massive right pleural effusion in a postoperative patient of percutaneous nephrolithotomy leading to severe respiratory distress is reported. A high degree of clinical suspicion and prompt intervention by insertion of an intercostal drainage tube prevented the patient from going in to respiratory failure. The development of arrhythmias confused the picture increasing the morbidity of the patient. However, the patient was managed in an intensive care unit with intercostal chest tube insertion and antiarrhythmic agents. After correction of the specific cause of the effusion the intercostal tube was removed on the 4th day without further recurrence of the effusion.


Sharma V.,Kailash Hospital | Biswas D.,Hindurao Hospital
General Hospital Psychiatry | Year: 2012

Cobalamin deficiency commonly presents with a wide range of neuropsychiatric manifestations ranging from myelopathy, neuropathy, optic neuritis and dementia to mood disorders, chronic fatigue and psychosis even without classical hematological abnormalities like anemia and macrocytosis. However, obsessive compulsive disorder (OCD) in relation to vitamin B12 deficiency has not been described so far. We report a case of middle-aged man presenting with OCD, low serum cobalamin and a positive family history of vitamin B12 deficiency who responded well to methylcobalamin replacement. © 2012 Elsevier Inc.


PubMed | Hindurao Hospital
Type: Journal Article | Journal: Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine | Year: 2014

A case of massive right pleural effusion in a postoperative patient of percutaneous nephrolithotomy leading to severe respiratory distress is reported. A high degree of clinical suspicion and prompt intervention by insertion of an intercostal drainage tube prevented the patient from going in to respiratory failure. The development of arrhythmias confused the picture increasing the morbidity of the patient. However, the patient was managed in an intensive care unit with intercostal chest tube insertion and antiarrhythmic agents. After correction of the specific cause of the effusion the intercostal tube was removed on the 4(th) day without further recurrence of the effusion.


PubMed | Hindurao Hospital
Type: Journal Article | Journal: Journal of anaesthesiology, clinical pharmacology | Year: 2016

Penetrating eye injuries are a challenge for the anesthesiologists in emergency due to increase in intraocular pressure (IOP). The aim of this study was to evaluate the effects of intravenous dexmedetomidine premedication on changes in IOP and hemodynamic response following laryngoscopy and tracheal intubation.Hundred patients aged 18-60 years undergoing elective nonophthalmic surgery were divided into two groups of 50 each. Group D received a bolus dose of dexmedetomidine (0.4 g/kg) diluted to 20 ml normal saline and Group C received normal saline (0.4 ml/kg) over 10 min as premedication. Heart rate (HR), systolic blood pressure (SBP) and IOP were measured and recorded before premedication (T1), 5 and 10 m after premedication (T2, T3), immediately after induction, intubation and then 1, 3, 5 min after intubation (T4, 5, 6, 7, 8).HR was comparable in both groups at preoperative level, but it was significantly low in the drug group when compared with the control group at T4-T8 (P = 0.034, P < 0.001, 0.001, 0.036 and 0.001, respectively). The SBP was comparable in both the groups at baseline and till before induction. At T4-T8 there was a fall in SBP in Group D compared to the Group C (P = 0.045, P = 0.007, 0.001, 0.001 and 0.001, respectively). The baseline IOP was comparable in both the groups (P = NS). There was a significant fall in the IOP in Group D, 5 min after the drug infusion compared to Group C, which was sustained till 5 min after intubation (T8) (P < 0.001 at all intervals).Dexmedetomidine premedication in the dose of 0.4 g/kg lowers the IOP and attenuates the pressor response to laryngoscopy and intubation.

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