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Dehradun, India

Sandhir R.K.,Plastic Surgeon Scores.org | Jindal B.R.,Plastic Surgeon Scores.org | Sandhir S.,HIMS
Indian Journal of Plastic Surgery | Year: 2011

Background: Depressed scars in the neck pose a cosmetic problem. There is a need to fill the lost tissue volume defect between the surface and deeper tissues. It is preferable that the filling is done by autologous tissue which is available in substantial amount in the adjoining area. There should be no donor site morbidity. Platysma muscle flap meets these criteria. Materials and Methods: Platysma muscle flap was advanced into the defect after excision of depressed scar. The procedure was done under local anesthetic in two patients. Result: The result was a 'good scar' with scar lying in the transversely oriented neck lines. Conclusions: Platysma muscle flap has a definitive role in revision surgery of depressed scars in neck as it provides an ideal tissue for lost tissue volume. Source


Qayoom S.,HIMS | Durga G.,RGCIRC | George S.,RGCIRC | Rahman K.,SGPGI
Indian Journal of Pathology and Microbiology | Year: 2015

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive neoplasm classified under acute myeloid leukemia (AML) and related precursor neoplasm by current WHO classification. Elderly male are commonly affected with cutaneous lesion being the hallmark of disease presentation. The disease progresses rapidly and sooner or later involves bone marrow and peripheral blood. Cases presenting primarily as leukemia without cutaneous involvement is a rarity with about 29 cases reported in literature till date. Characteristic immunophenotype of CD4 + /CD56 +/- cells expressing antigens associated with plasmacytoid dendritic cells like CD123, TCL1, BDCA2/CD303, cutaneous lymphocyte-associated and interferon dependent molecule MxA, in absence of any other lineage specific marker confirms the diagnosis. The disease has a poor survival and no standardized therapeutic strategy in the current scenario. A case of 25-year-male presenting with leukemic BPDCN without cutaneous involvement is presented here, who was treated with AML like protocol followed by hematopoietic stem cell transplantation, but succumbed to the disease within 8 months of diagnosis. The present case is being first to be reported from India. Source


Udasimath S.,HIMS | Arakeril S.U.,Bldeas Shri Bm Patil Medical College | Karigowdar M.H.,Bldeas Shri Bm Patil Medical College | Yelikar B.R.,Bldeas Shri Bm Patil Medical College
Journal of Clinical and Diagnostic Research | Year: 2012

Background: The Cell Block (CB) technique is one of the oldest methods which is used for the evaluation of body cavity fluids. The accurate identification of the cells as either malignant or reactive mesothelial cells is a diagnostic problem in cytological conventional Smears (CS). As compared to the older methods, a new method of cell block preparation which is being used, which uses 10% alcohol-formalin as a fixative, increases the cellularity, gives better morphological details and helps in improving the sensitivity of the diagnosis. Multiple sections can be obtained by the CB method for the special stains and immunohistochemistry studies. Aims: To know the role, utility and the sensitivity of the cell block method in the diagnosis of malignant ascitic fluid effusions. Materials and Methods: This study was conducted in the Cytology Section of the Department of Pathology. 44 peritoneal fluid samples were subjected to a diagnostic evaluation for over a period of 20 months. The cell blocks were prepared by using 10% alcohol-formalin as a fixing agent along with the CS. The cellularity, architectural patterns, morphological details and the cytoplasmic and the nuclear details were studied both in the CS and the CB methods. Mc. Naemer's χ2 test was used to identify the additional yield for malignancy which was obtained by the CB method. Results: The additional yield for malignancy was 13.63% more as was obtained by the CB method. Conclusions: The CB method provides high cellularity, better architectural patterns, morphological details and an additional yield for malignant cells. Therefore, the CB technique could be considered as a useful adjuvant in evaluating the fluid cytology for a final cytodiagnosis, along with the routine CS method. Source


Sinhasan S.P.,Indira Gandhi Medical College and Research Institute | Palachandra A.,HIMS
Annals of Tropical Medicine and Public Health | Year: 2012

Hydatid disease has a worldwide distribution and causes health problems in endemic countries. The prevalence of primary muscular hydatid disease is reported to be only 0.5% because muscle is an unfavorable site for infestation as a result of its high levels of lactic acid. Primary intramuscular hydatid cyst presents a diagnostic problem not only because of the unusual location and low prevalence, but also because complicated cysts may imitate solid or complex lesions. We report an unusual case of primary hydatidosis of the calf muscles, in which a wide excision was performed without causing any damage to the cyst wall. Injudicious approach in the management of these rare presentations may be the root cause of severe anaphylactic shock and systemic dissemination. Intramuscular hydatid cysts grow gradually and may mimic a soft tissue tumor; thus, the diagnosis of soft-tissue hydatid cysts needs a high index of suspicion. Source


News Article
Site: http://phys.org/chemistry-news/

Researchers from the University of Amsterdam's Van 't Hoff Institute for Molecular Sciences (HIMS) have developed a range of synthetic biomimetic compounds to replace the relatively expensive natural NADH and NADPH coenzymes in enzymatic conversions of industrial relevance. They show that some of the compounds even outperform their natural counterparts. The research has been published in the Journal of the American Chemical Society (JACS). The search for affordable, green biocatalytic processes is a challenge for chemicals manufacture. Not only is the use of natural coenzymes economically hardly viable, the moderate stability of these molecules thwarts their implementation in large scale catalytic processes that employ coenzyme recycling. Now, in a joint JACS publication with researchers from TU Delft and the University of Manchester, Dr Tanja Knaus from the HIMS Biocatalysis group led by Dr Francesco Mutti describes the great potential of a range of synthetic biomimetics for replacing the natural coenzymes NAD(P)H in redox biocatalysis. The new biomimetic coenzymes are inexpensive to manufacture and more stable than their biological counterparts, that are required as hydride source (reduced form NAD(P)H) or acceptor (oxidised form NAD+) in selective enzymatic reductive and oxidative reactions. The HIMS Biocat researchers have investigated the performance of their biomimetic compounds with a wide range of oxidoreductase biocatalysts, in particular enzymes belonging to the family of the "ene"-reductases. These enzymes catalyse the asymmetric reduction of activated alkenes and their activity can be exploited for the synthesis of high value chemical products such as pharmaceuticals and agrochemicals. The researchers elucidated the performance of the biomimetics through steady-state and rapid-reaction kinetics as well as the analysis of the X-ray crystal structures of the biomimetics in complex with the ene-reductase XenA. The analysis of the kinetic parameters shows that, in selected cases, these biomimetics outperform the natural coenzymes. That laboratory-based designs can outperform those available in Nature is quite notable. Moreover, the biomimetics have been successfully applied to the asymmetric catalytic reduction of activated alkenes. It is noteworthy that the biomimetics could be employed in catalytic amount as they were recycled in situ at the expense of formate. The HIMS Biocat researchers conclude that the implementation of these synthetic biomimetics - as well as the design of more sophisticated analogues capable of operating with a variety of other oxidoreductases - will facilitate the use of redox biocatalysts in chemicals production and thereby transform the use of oxidoreductases more widely in industrial biocatalysis. They expect that the "Better-than-Nature" biomimetics can find widespread application in fine and specialty chemicals production by harnessing the power of high stereo-, regio-, and chemoselective redox biocatalysts and enabling reactions under mild conditions and at low cost. Explore further: Cyanobacteria can manufacture biocatalysts for the industry More information: Tanja Knaus et al. Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes, Journal of the American Chemical Society (2016). DOI: 10.1021/jacs.5b12252

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