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Gupta J.,Himachal Institute of Pharmacy | Kumar D.,Kurukshetra University
Asian Pacific Journal of Tropical Disease | Year: 2012

Objective: To evaluate the gastric anti-ulcer activity of methanolic extract of . Cayratia trifolia L. (MECT) (Vitaceae) leaves in experimental animals. Methods: MECT was investigated in pylorus ligation and ethanol induced ulcer models in Wistar rats. In both models, the common parameter determined was ulcer index. MECT at doses of 250, 500 mg/kg (p.o.) was used to determine whether it could produce significant inhibition of the gastric lesions induced by pylorus ligation and ethanol. Results: The extract (250 and 500 mg/kg) showed significant (. P<0.05) reduction in gastric volume and ulcer index as compared to the control in both of the two models. Conclusions: It can be concluded that MECT possesses antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity. © 2012 Asian Pacific Tropical Medicine Press.

Ashok K.,Himachal Institute of Life Science | Bisht B.S.,Central University of Costa Rica | Manish K.,Himachal Institute of Pharmacy | Lalit K.,Himachal Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2010

Heavy metals and other pollutants in the environment damage to the plants. Heavy metals include lead (Pb), cadmium (Cd), zinc (Zn), arsenic (As), nickel (Ni), chromium (Cr), copper (Co) etc. A pollutant is any substance in the environment, which causes objectionable effects, impairing the welfare of the environment, reducing the quality of plant life and may eventually cause plant death. Such a substance has to be present in the environment beyond a set or tolerance limit, which could be either a desirable or acceptable limit. Hence, environmental pollution is the presence of a pollutant in the environment viz. air, water and soil, which may be poisonous or toxic and cause harm to plants in the polluted environment. Increases of metal content ions when present at an elevated level in the environment are absorbed by roots of the plants and translocated to different plant parts, leading to impaired metabolism and reduced growth and Ni and Zn considered as essential micronutrients, increased concentration poses toxicity on metabolic and cytological activity of the plants. In the present investigation, the three plant of Indian pulses Vigna mungo, Vigna radiata and Glycine max which is the major pulses for farmer and all, were taken and the effect of different grade of Ni and Zn observed for the growth in pulses. The plant of one week and one month were taken for the present study. It was observed that the Ni and Zn had reduced cytological activity in the growing plant contrasting to control plants. They, thus reduce the plant growth in excess.

gupta A.,Doon valley institute of Pharmacy | Bhardwaj A.,Himachal institute of Pharmacy | gupta J.,Himachal institute of Pharmacy | Bagchi A.,Himachal institute of Pharmacy
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To evaluate the antiimplantation properties of the Pet ether extract of leaves of Cayratia trifolia Linn (C. trifolia) in rat by observing the implants after dosing the test extract. Materials: Pregnant females were separated and divided into thirteen groups each containing six animalsand were given Tween-80, 2% v/v. prepared extracts (PEECT) at the dose of 250 mg/kg and 500 mg/kg respectively. All the extracts and vehicle were administered orally to the animals once daily throughout 7 days of pregnancy. On 10th day of pregnancy, the animals were laparotomized under light ether anaesthesia and number of implants present in both the uterine horns was counted. Each pup was weighed and examined for gross defects. Result: Among the two doses of PEECT, a dose of 500 mg/kg was found to be significant (P<0.01) and percentage inhibition of implantations in rats, at doses of 250 and 500 mg/kg, were found to be in PEECT 37.1, 56.7 respectively when compared with control. The highest activity was observed with the 500 mg/kg dose when the implantation were calculated about 10th day after the administration of the test extracts. Conclusions: It can be concluded from the study that the Petroleum ether extract of C. trifolia Linn. leaves have potent antiimplantation activity. © 2012 Asian Pacific Tropical Biomedical Magazine.

Rawat S.,Himachal Institute of Pharmacy | Singh R.,Himachal Institute of Pharmacy | Thakur P.,Himachal Institute of Pharmacy | Kaur S.,Doon valley Institute of Pharmacy and Medicine | Semwal A.,Himachal Institute of Pharmacy
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

This paper presents a review of plants identified from various ethno botanical surveys and folklore medicinal survey with Wound healing activity. Wound is defined as the disruption of the cellular and anatomic continuity of a tissue. Wound may be produced by physical, chemical, thermal, microbial or immunological insult to the tissues. The process of wound healing consists of integrated cellular and biochemical events leading to re-establishment of structural and functional integrity with regain of strength in injured tissues. This review discuss about Wound healing potential of plants, its botanicalname, Common name, family, part used and references, which are helpful for researcher to development new Wound healing formulations for human use. © 2012 Asian Pacific Tropical Biomedical Magazine.

OBJECTIVE: In recent years, excipient development has become major area of research in pharmaceutical drug delivery because it influences the formulation development and drug delivery process in various ways. In modern pharmaceutical science biopolymers are choice of research as excipient because of their low toxicity, biocompatibility, biodegrability, stability and renewable nature. Chitosan, a biodegradable polysaccharide derived from chitin and found widely in nature, possesses properties making it particularly suitable as a carrier, including its high viscosity, charge distribution and release mechanisms. Our present research work includes preparation and characterization of chitosan-moxifloxacin conjugates designed in accordance with specific biomedical requirements. METHODS: In this research work chitosan based chitosan-moxifloxacin conjugates have been successfully formulated by using distilled water and glacial acetic acid mixture and the film was made by solution casting method. Formulated films were characterized by various analytical methods such as UV, IR and DSC as well as biological methods. RESULTS: The antibacterial activity of chitosan-moxifloxacin conjugates was tested against various microorganisms viz, gram positive bacteria’s Streptococcus pneumoniae and Staphylococcus aureus and the results indicated that the antibacterial activity of chitosan-moxifloxacin conjugates was several time greater than that of parent drug moxifloxacin. This may be due to the favorable pharmacokinetics, pharmacodynamics, excellent bacterial susceptibility and good stability of the drug conjugates. CONCLUSION: This proposed combination may result in the enhancement of the separate activities of chitosan and moxifloxacin. © 2014, Marmara University. All rights reserved.

Mamta K.,Boomi.in | Abhishek B.,Himachal Institute of Pharmacy | Rohit B.,Himachal Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2010

The root of Rotula aquatica is also called as pashanbed, belonging to the family Borogenaceae. It is widely distributed in India from kumaun to Assam and western to southern India.The medicinal values of plant lie in their component phytochemicals such as alkaloids, flavonoids, phenolic compounds and other nutrients like as amino acid, proteins, which produce a definite physiological action on the human body. The present study attempts pharmacognostic studies of root, extraction, identification of chemical constituents from the crude extracts of different extracts of Rotula aquatica.Macroscopic as well as microscopic studies of any crude drug are the primary steps to establish its botanical quality control before going to other studies. Hence phamacognostic studies of crude drug play a very important role in identifying the purity and quality of crude drugs. The present investigation reveals phamacognostic characters which include morphology, T.S, Powder microscopy, Phytochemical screening, and further isolation and identification of Phytoconstituents from ethanolic extract of Rotula aquatica.

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