Himachal Institute of Pharmacy

Himachal, India

Himachal Institute of Pharmacy

Himachal, India
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Yashwant,Himachal Institute of Pharmacy | Singh R.,Maharishi Markandeshwar University
International Journal of Pharmaceutical Quality Assurance | Year: 2016

A simple, sensitive, economical UV Spectrophotometric method was developed for the simultaneous estimation of Lornoxicam and Paracetamol in bulk and tablet formulation by using Urea solution as Hydrotropic agent. The λmax for Lornoxicam and Paracetamol was found to be 384 nm and 244 nm respectively and both Lornoxicam and Paracetamol obey Beer-Lambert’s law in the concentration range of 2-10 µg/ml (r2=0.999) and 20-60 µg/ml. (r2=0.999) in 8M Urea (Hydrotropic agent) respectively. The developed method was validated according to ICH guidelines and value of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. © 2017, International Journal of Pharmaceutical Quality Assurance. All rights reserved.


Esha V.,Manav Bharti University | Shilpa C.,Manav Bharti University | Bharat P.,Manav Bharti University | Neeru,Himachal Institute of Pharmacy
International Journal of Pharmacognosy and Phytochemical Research | Year: 2016

In the present study, an attempt has been made to highlight the importance of the plant Dendrobium macraei Lindl. (family-Orchidaceae) in the field of traditional medicines. It is commonly known as Swarna Jivanti. The plant is one of the important Rasayana drugs in Ayurveda. It is mainly found in Sikkim Himalayas, Bengal and Khasia mountains at an altitude of 7000-8000 ft. The plant has been reported to be useful as cooling, alterative, astringent to the bowels, stimulant, nervine tonic, aphrodisiac, expectorant, in asthma, bronchitis, ‘tridosha’, throat troubles, fevers, burning sensations, biliousness, diseases of the eye and blood. Plant is stimulant and tonic. The plant is reported to contain alkaloids, carbohydrates, flavonoids, steroids, tannins and phenolic compounds. Jibantine, resinous principles α and β jibantic acid and diosgenin derivatives like denfigenin and defuscin as steroids are reported as chief constituents in Dendrobium macraei. The present study was undertaken for the development of physico- chemical parameters and phytochemical evaluation including development of chromatographic fingerprinting profile of various extracts prepared by thin layer chromatography (TLC) and fluorescence analysis of various parts of plant used. This study will help in authentication of plant material and will acts as standardization parameter for future study purpose. © 2016, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.


Rakesh M.R.,Himachal Institute of Pharmacy | Ashok K.,Himachal Institute of Life science | Kumar S.A.,Central University of Costa Rica | Amitabh T.,Himachal Institute of Life science
International Journal of Pharmaceutical Sciences Review and Research | Year: 2010

All shampoos are basically water and detergent mixtures. The main objective of this study was to eliminate harmful materials from shampoo formulation and substitute them with a safe natural product. Formulators must play an active role in educating the consumers about the potential harmful effects of synthetic detergents and other chemical additives present in shampoos. We had taken three plants extract to formulate the herbal shampoo. The taken extracts of plant were Asparagus racemosus, Acacia concin, Sapindus mukorossi. Defatted air-dried plants powders were extracted with methanol in soxhlet apparatus set at 60°C for 24 hours. The solvent was evaporated at 50° C using rotary vacuum. The phytochemical screening was done to identify the natural phytochemical in these three plant extracts. The identification of all phytochemicals was finished through TLC. To formulate a clear shampoo base, definite amounts of saponin and salt were added to an aqueous solution containing extracts and juices along with glycerin (1%), methyl paraben (0.05%) and EDTA (0.15%) etc. Formulation was prepared by slightly heating and adding the weighed quantity of herbal ingredients extracts and juices. The pH of the Shampoo was adjusted to 5.5, to retain the acidic mantle of scalp. Synthetic preservatives have sometimes been the cause of adverse effects among consumers. We had used the physico-chemical approach toward preservation and by formulating a self preserving shampoo and it avoided this risk posed by chemical preservatives.


Kumar A.,Himachal Institute of Life science | Mali R.R.,Himachal Institute of Pharmacy
International Journal of Pharmaceutical Sciences Review and Research | Year: 2010

Shampooing is the most common form of hair treatment. Shampoos are primarily been products aimed at cleansing the hair and scalp. In the present scenario, it seems improbable that herbal shampoo, although better in performance and safer than the synthetic ones, will be popular with the consumers. A more radical approach in popularizing herbal shampoo would be to change the consumer expectations from a shampoo, with emphasis on safety and efficacy. We have evaluated and compared the herbal shampoo, which was formulated in previous study, with two marketed shampoos. The findings of this investigation reveal that synthetic preservatives have sometimes been the cause of adverse effects among consumers. We have used the physico-chemical approach to preservation and by formulating a self preserving shampoo, have avoided this risk posed by chemical preservatives. However, the aesthetic attributes, such as lather and clarity, of the laboratory shampoo are not comparable with the marketed shampoos. The foam volume was on a par. Although the retail products were not fare so well in the tests conducted by us, they enjoy market popularity, especially if they foam well. This is mainly due to the false notion among consumers that 'a shampoo that foams well, works well', and no real effort on the part of manufacturers to counter this fallacy.


Yashwant,Himachal Institute of Pharmacy
International Journal of Pharmaceutical Quality Assurance | Year: 2016

A new, simple, accurate, precise and selective reverse phase-high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of Metformin hydrochloride, Pioglitazone hydrochloride and Gliclazide as API and in synthetic mixture is developed. The determination was carried out on a ODS, (250 X 4.6 mm, 5 μm) column using a mobile phase of buffer solution: acetonitrile (55:45 % v/v, pH 5.0). The flow rate was 1.0 ml/min with detection at 230 nm. The retention time for Metformin hydrochloride, Pioglitazone hydrochloride and Gliclazide were 2.11 min, 8.6 min and 10.49 min respectively. Metformin hydrochloride, Pioglitazone hydrochloride and Gliclazidel showed a linear response in the concentration range of 50-350 µg/ml, 1.5-10.5 µg/ml and 6-42 µg/ml respectively. The results of analysis have been validated statistically and by recovery studies. The mean recoveries found for Metformin hydrochloride was 99.05%, Pioglitazone hydrochloride was 99.91% and Gliclazide was 99.26%. Developed method was found to be simple, accurate, precise and selective for simultaneous estimation of Metformin hydrochloride, Pioglitazone hydrochloride and Gliclazide as API and in synthetic mixture. © 2017, International Journal of Pharmaceutical Quality Assurance. All rights reserved.


Gupta J.,Himachal Institute of Pharmacy | Kumar D.,Kurukshetra University
Asian Pacific Journal of Tropical Disease | Year: 2012

Objective: To evaluate the gastric anti-ulcer activity of methanolic extract of . Cayratia trifolia L. (MECT) (Vitaceae) leaves in experimental animals. Methods: MECT was investigated in pylorus ligation and ethanol induced ulcer models in Wistar rats. In both models, the common parameter determined was ulcer index. MECT at doses of 250, 500 mg/kg (p.o.) was used to determine whether it could produce significant inhibition of the gastric lesions induced by pylorus ligation and ethanol. Results: The extract (250 and 500 mg/kg) showed significant (. P<0.05) reduction in gastric volume and ulcer index as compared to the control in both of the two models. Conclusions: It can be concluded that MECT possesses antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity. © 2012 Asian Pacific Tropical Medicine Press.


gupta A.,Doon valley institute of Pharmacy | Bhardwaj A.,Himachal institute of Pharmacy | gupta J.,Himachal institute of Pharmacy | Bagchi A.,Himachal institute of Pharmacy
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To evaluate the antiimplantation properties of the Pet ether extract of leaves of Cayratia trifolia Linn (C. trifolia) in rat by observing the implants after dosing the test extract. Materials: Pregnant females were separated and divided into thirteen groups each containing six animalsand were given Tween-80, 2% v/v. prepared extracts (PEECT) at the dose of 250 mg/kg and 500 mg/kg respectively. All the extracts and vehicle were administered orally to the animals once daily throughout 7 days of pregnancy. On 10th day of pregnancy, the animals were laparotomized under light ether anaesthesia and number of implants present in both the uterine horns was counted. Each pup was weighed and examined for gross defects. Result: Among the two doses of PEECT, a dose of 500 mg/kg was found to be significant (P<0.01) and percentage inhibition of implantations in rats, at doses of 250 and 500 mg/kg, were found to be in PEECT 37.1, 56.7 respectively when compared with control. The highest activity was observed with the 500 mg/kg dose when the implantation were calculated about 10th day after the administration of the test extracts. Conclusions: It can be concluded from the study that the Petroleum ether extract of C. trifolia Linn. leaves have potent antiimplantation activity. © 2012 Asian Pacific Tropical Biomedical Magazine.


Rawat S.,Himachal Institute of Pharmacy | Singh R.,Himachal Institute of Pharmacy | Thakur P.,Himachal Institute of Pharmacy | Kaur S.,Doon valley Institute of Pharmacy and Medicine | Semwal A.,Himachal Institute of Pharmacy
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

This paper presents a review of plants identified from various ethno botanical surveys and folklore medicinal survey with Wound healing activity. Wound is defined as the disruption of the cellular and anatomic continuity of a tissue. Wound may be produced by physical, chemical, thermal, microbial or immunological insult to the tissues. The process of wound healing consists of integrated cellular and biochemical events leading to re-establishment of structural and functional integrity with regain of strength in injured tissues. This review discuss about Wound healing potential of plants, its botanicalname, Common name, family, part used and references, which are helpful for researcher to development new Wound healing formulations for human use. © 2012 Asian Pacific Tropical Biomedical Magazine.


OBJECTIVE: In recent years, excipient development has become major area of research in pharmaceutical drug delivery because it influences the formulation development and drug delivery process in various ways. In modern pharmaceutical science biopolymers are choice of research as excipient because of their low toxicity, biocompatibility, biodegrability, stability and renewable nature. Chitosan, a biodegradable polysaccharide derived from chitin and found widely in nature, possesses properties making it particularly suitable as a carrier, including its high viscosity, charge distribution and release mechanisms. Our present research work includes preparation and characterization of chitosan-moxifloxacin conjugates designed in accordance with specific biomedical requirements. METHODS: In this research work chitosan based chitosan-moxifloxacin conjugates have been successfully formulated by using distilled water and glacial acetic acid mixture and the film was made by solution casting method. Formulated films were characterized by various analytical methods such as UV, IR and DSC as well as biological methods. RESULTS: The antibacterial activity of chitosan-moxifloxacin conjugates was tested against various microorganisms viz, gram positive bacteria’s Streptococcus pneumoniae and Staphylococcus aureus and the results indicated that the antibacterial activity of chitosan-moxifloxacin conjugates was several time greater than that of parent drug moxifloxacin. This may be due to the favorable pharmacokinetics, pharmacodynamics, excellent bacterial susceptibility and good stability of the drug conjugates. CONCLUSION: This proposed combination may result in the enhancement of the separate activities of chitosan and moxifloxacin. © 2014, Marmara University. All rights reserved.


Mamta K.,Boomi.in | Abhishek B.,Himachal Institute of Pharmacy | Rohit B.,Himachal Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2010

The root of Rotula aquatica is also called as pashanbed, belonging to the family Borogenaceae. It is widely distributed in India from kumaun to Assam and western to southern India.The medicinal values of plant lie in their component phytochemicals such as alkaloids, flavonoids, phenolic compounds and other nutrients like as amino acid, proteins, which produce a definite physiological action on the human body. The present study attempts pharmacognostic studies of root, extraction, identification of chemical constituents from the crude extracts of different extracts of Rotula aquatica.Macroscopic as well as microscopic studies of any crude drug are the primary steps to establish its botanical quality control before going to other studies. Hence phamacognostic studies of crude drug play a very important role in identifying the purity and quality of crude drugs. The present investigation reveals phamacognostic characters which include morphology, T.S, Powder microscopy, Phytochemical screening, and further isolation and identification of Phytoconstituents from ethanolic extract of Rotula aquatica.

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